ctsa infrastructure for aids research

ctsa 艾滋病研究基础设施

• 批准号: 8175551
• 负责人: ROBERT M CALIFF
• 金额: $ 9.22万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-09-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8175551
• 关键词: Acquired Immunodeficiency Syndrome; Area; Basic Science; Bioinformatics; Biological Process; Caring; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communities; Duke Comprehensive Cancer Center; Environment; Faculty; Fostering; Funding; Genome; Grant; Healthcare; Home environment; House Staffs; Human Resources; Individual; Informatics; Institutes; Intervention; Laboratories; Leadership; Link; Measurement; Medical; Methods; Modeling; National Center for Research Resources; Nursing Schools; Outcome; Patients; Pediatric Research; Population; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; School Nursing; Schools; Science Policy; Students; Training; Translating; Translational Research; Universities; bench to bedside; career; cost; design; graduate student; health care delivery; improved; novel; programs; success

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. Duke proposes to create a Clinical Translational Science Institute (CTSI). This institute will accomplish four specific aims: 1) To create an institute that will transform how fundamental discoveries are translated into improved medical care by supporting creative translational research teams. The institute will provide leadership and resources for original translational and clinical research, and it will develop and perform studies regarding novel methods and approaches to translational and clinical science. 2) Create an environment in which trainees at all levels, including medical and nursing school students, physical therapists, pharmacologists, house staff, fellows, graduate students, junior faculty and career transition faculty can be trained in translational and clinical research. The training will be built on the principle that a rich clinical and translational research environment will provide Duke trainees with models and opportunities for success. 3) Integrate translational and clinical science by fostering collaboration among Duke's departments, institutes, centers, and schools using human resources supported by modern bioinformatics and a new clinical research unit designed to integrate intensive measurements of biological processes. 4), Develop a community model for understanding how to translate the findings of research from bench to bedside to populations using advanced informatics and health services delivery methods. The Duke CTSI will be founded on three entities, or pillars, including the Duke Translational Research Institute (DTRI), the Duke Clinical Research Institute (DCRI), and the Duke Center for Community Research (DCCR). These three entities will bring together and expand existing programs, and will be designed to emphasize the continuities along the spectrum of research that begins in a basic science laboratory and concludes with novel therapies that change outcomes for individual patients. These three pillars (DCRI, DTRI, and DCCR) will be administratively joined into the new Duke Clinical and Translational Science Institute (Duke CTSI), the core of this application. This new institute will link With other key programs, including the Duke Comprehensive Cancer Center, the Duke University School of Nursing, and the Duke Institute for Genome Sciences and Policy, to create a comprehensive home for clinical and translational researchers. The creation of the CTSI is patricianly relevant to public health as it will create an environment that will foster speedier delivery of new interventions and healthcare practices to the community.

该子项目代表CTSA资金百分比的估计值 被用于广泛的研究领域（艾滋病研究，儿科研究或 临床试验）。 列出的总成本只是CTSA数量的估计值 基础设施朝向这一研究领域，而不是直接提供的资金 NCRR授予subproject或subproject人员。 杜克建议建立一个临床转化科学研究所（CTSI）。该研究所将实现四个具体目标：1）创建一个研究所，该研究所将通过支持创意翻译研究团队来改变基本发现如何改善医疗服务。该研究所将为原始的翻译和临床研究提供领导和资源，并将开发和执行有关新颖方法和转化和临床科学方法的研究。 2）创造一个环境，其中包括医学和护理学校的学生，物理治疗师，药理学家，房屋工作人员，研究员，研究生，初级教职员工和职业过渡教师，都可以在翻译和临床研究中接受培训。该培训将基于以下原则：丰富的临床和转化研究环境将为杜克学员提供成功的模型和机会。 3）通过使用现代生物信息学支持的人力资源和一个新的临床研究部门的支持，通过促进杜克部门，机构，中心和学校之间的合作来整合转化和临床科学，并旨在整合生物学过程的密集度量。 4），开发一个社区模型，以了解如何使用先进的信息学和健康服务交付方法将研究结果从长凳转换为床边。 CTSI杜克大学将建立在三个实体或支柱上，包括杜克翻译研究所（DTRI），杜克临床研究所（DCRI）和杜克社区研究中心（DCCR）。这三个实体将汇集并扩大现有计划，并将旨在强调沿着基础科学实验室始于研究范围的连续性，并以新的疗法结论，这些疗法改变了单个患者的结果。这三个支柱（DCRI，DTRI和DCCR）将在该应用程序的核心中行政上加入新的杜克临床和转化科学学院（Duke CTSI）。这个新研究所将与其他关键计划联系起来，包括杜克大学综合癌症中心，杜克大学护理学院和杜克大学基因组科学与政策研究所，为临床和转化研究人员创建综合的住所。 CTSI的创建与公共卫生非常相关，因为它将创建一个环境，该环境将促进向社区迅速提供新的干预措施和医疗保健实践。