Exercise and Quality of Life in Severely Burned Children

严重烧伤儿童的运动和生活质量

基本信息

批准号：
8223324
负责人：
Oscar E. Suman-Vejas
金额：
$ 26.43万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-01 至 2015-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8223324
关键词：
18 year old Acute Aerobic Aerobic Exercise Affect Age Alanine Applications Grants Body Composition Body Surface Area Burn injury Cardiopulmonary Catabolism Characteristics Child Child health care Clinical Collection Contracture Data Doctor of Philosophy Education Environment Equilibrium Equipment and supply inventories Exercise Exercise stress test Future Grant Guidelines Health Home environment Hospitals Hour Ingestion Instruction Joints Knowledge Lead Leg Medical Motivation Muscle Occupational Therapy Operative Surgical Procedures Outcome Outcome Measure Patient Discharge Patients Pediatric Hospitals Physical Function Physical therapy Physiological Process Protein Biosynthesis Proteins Quality of life Questionnaires Randomized Rehabilitation therapy Reporting Research Personnel Resistance Roentgen Rays Skeletal Muscle Structure Testing Time Training Urea Urine Writing bone mass clinical application clinically relevant improved muscle form muscle strength novel primary outcome programs psychosocial psychosocial rehabilitation response standard of care treatment strategy

项目摘要

r The current Standard of Care for the rehabilitation of severely burned children is to discharge the patient from the hospital, with a written set of instructions for physical and occupational therapy activities at home, in an unsupervised environment. These activities do not significantly impact the persistent and extensive skeletal muscle catabolism and weakness characteristic of severe burns. The central hypothesis of this grant is that a supervised anld structured aerobic and resistance exercise program implemented at hospital discharge in severely burned children will improve physical structure and function, allowing for an improvement in quality of life (QOL). We propose the following specific aims (SA): SA1 will test the hypothesis that in severely burned children, a supervised and structured exercise program will significantly increase muscle mass and bone mass more than the current Standard of Care. SA2 will test the hypothesis that in burned children, <p supervised and structured exercise program will significantly increase peak aerobic capacity and muscle strejngth more than the current Standard of Care. SA3 will test the hypothesis that a supervised and structure'd exercise program will significantly increase net protein synthesis compared to the current Standard of Care in burned children and lead to an improvement in lean mass and muscle strength. SA4 will test the hypothesis that in burned children, a supervised and structured exercise program will significantly improve QOL more than the current Standard of Care. Primary outcomes are peak aerobic capacity assessed with a.cardiopulmonary exercise test; muscle strength, using leg dynamometry, muscle mass assessed usingidual X-ray absorptiometry, and net protein balance assessed using urea enrichment. Finally, psychosocial health using the Child Health Questionnaire, (PF-28 and CF-87) will be assessed. Assessment of physical function, and QOL will be done at hospital discharge, at the end of the 12-week exercise program, at 12 months, and at 24 months post burn. Assessment of net protein balance will be done at hospital discharge, c^nd at the end of the 12-week exercise program. It is expected that these proposed studies will expand the present knowledge of physical and psychosocial rehabilitation programs for severely burned children. Furthermore, we believe that these proposed studies will result in novel and clinically relevant data that may jn turn establish new guidelines for the Standard of Care of burned children.

r 目前严重烧伤儿童康复的护理标准是让患者出院来自医院，并附有一套在家进行物理和职业治疗活动的书面说明，无人监督的环境。这些活动不会对持久和广泛的影响产生重大影响骨骼肌分解代谢和严重烧伤的无力特征。本次资助的中心假设是在医院实施的监督和结构化有氧运动和抗阻运动计划严重烧伤儿童的出院将改善身体结构和功能，从而使生活质量（QOL）的改善。我们提出以下具体目标 (SA)： SA1 将测试假设对于严重烧伤的儿童，有监督和结构化的锻炼计划将显着增加肌肉质量和骨质量超过当前的护理标准。 SA2将检验假设对于烧伤儿童来说，监督和结构化的锻炼计划将显着提高峰值有氧运动能力和肌肉力量超过当前的护理标准。 SA3 将检验以下假设：与常规锻炼相比，有监督和结构化的锻炼计划将显着增加蛋白质的净合成烧伤儿童的现行护理标准，可改善瘦体重和肌肉力量。 SA4 将检验以下假设：对于烧伤儿童，监督和结构化的锻炼计划将比当前的护理标准显着提高生活质量。主要结果是有氧峰值通过心肺运动测试评估能力；肌肉力量，使用腿部测力法，肌肉使用独立X射线吸收测定法评估质量，并使用尿素富集评估净蛋白质平衡。最后，将使用儿童健康问卷（PF-28 和 CF-87）评估社会心理健康。身体机能和生活质量评估将在出院时、12 周结束时进行烧伤后 12 个月和 24 个月的锻炼计划。净蛋白质平衡的评估将出院时进行，并在 12 周锻炼计划结束时进行。预计这些拟议的研究将扩大目前对身心康复计划的了解严重烧伤的儿童。此外，我们相信这些拟议的研究将产生新颖且临床相关数据可能会为烧伤儿童的护理标准制定新的指南。