Global Network for Women's and Children's Health

全球妇女儿童健康网络

基本信息

批准号：
7477545
负责人：
EDWARD A. LIECHTY
金额：
$ 62.02万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-17 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7477545
关键词：
AIDS prevention AIDS/HIV problem Accounting Acquired Immunodeficiency Syndrome Acute Address Adherence Administrator Admission activity Adopted Advisory Committees Africa Africa South of the Sahara African African American Age Age-Months Age-Years Agriculture Allied Health Profession American Anesthesiology Animal Sources Appendix Applications Grants Area Arts Asthma Attention Attitude Award Awareness Basic Science Beds Behavioral Behavioral Medicine Behavioral Sciences Belief Bioethics Bioethics Consultants Biological Preservation Biometry Birth Breast Feeding Budgets Burn injury Cardiology Caregivers Caring Case Management Catchment Area Certification Cessation of life Chairperson Charge Child Child Abuse and Neglect Child Mortality Child health care Childhood Chlorine Cities Class Client Clinic Clinical Clinical Data Clinical Medicine Clinical Pharmacists Clinical Research Clinical Trials Clinical Trials, Other Cognitive Collaborations Combined Modality Therapy Commit Communicable Diseases Communication Communities Community Health Centers Community Outreach Community Services Commuting Computerized Medical Record Computers Condition Consent Consent Forms Consult Control Groups Counseling Country Coupled Cross-Sectional Studies Daily Data Data Collection Databases Democratic Republic of the Congo Demographic and Health Surveys Depth Dermatology Developed Countries Developing Countries Development Diagnosis Diarrhea Dietetics Discipline Discipline of Nursing Discipline of obstetrics Disease Disease Management Disease Progression Disinfection District Hospitals Doctor of Philosophy Drug Kinetics Economics Education Educational Curriculum Educational Status Educational process of instructing Educational workshop Elderly Electronic Mail Elements Elevation Eligibility Determination Emergency Medicine Enrollment Ensure Environment Environmental Health Epidemiologic Studies Epidemiology Ethical Issues Ethicists Ethics Ethnic Origin Ethnic group Evaluation Event Evidence based intervention Exhibits Faculty Failure Failure to Thrive Family Fellowship Fetal Growth Focus Groups Food Fostering Foundations Frequencies Funding Funding Agency Funding Opportunities Gambling Gastroenterology Gender General Population Goals Government Grant Group Meetings Growth HIV HIV Seropositivity HIV vaccine Haiti Head Head circumference Health Health Personnel Health Planning Health Promotion Health Sciences Health Services Health Services Research Health education Healthcare Heart Highly Active Antiretroviral Therapy Home environment Home visitation Hospital Referrals Hospitals House Call Household Housing Human Human Milk Human Resources Human Subject Research Husband Hygiene Immunization Immunization Programs Incidence Indiana Individual Infant Infant Food Infant Health Infant Mortality Infection Informatics Information Systems Informed Consent Institutes Institution Interdisciplinary Study Internal Medicine International Internet Intervention Interview Investigation Joints Journals Kenya Knowledge Laboratories Language Laws Lead Leadership Learning Left Length Life Life Experience Literature Live Birth Livestock Logical Observation Identifiers Names and Codes Longitudinal Studies Lung diseases Maintenance Malaria Malaria prevention Malnutrition Manuscripts Marriage Master of Public Health Maternal Mortality Maternal and Child Health Measurement Mediation Medical Medical Informatics Medical Records Medical Students Medicine Metabolic Methods Mission Modeling Monitor Morbidity - disease rate Mothers Multi-Institutional Clinical Trial Names National Institute of Child Health and Human Development Neck Neonatal Neonatal Intensive Care Units Neonatal Mortality Numbers Nutritional Nutritional Support Nutritional status Nutritionist Obstetric Surgical Procedures Office for Human Research Protections Office for Protection from Research Risks Operative Surgical Procedures Orphan Outcome Pain Measurement Pain management Paper Participant Pathology Patient Care Patients Pediatric Oncology Pediatric Research Pediatrics Peer Review Performance Perinatal Personal Satisfaction Persons Pharmacology Philosophy Physician Executives Physicians Physiology Placement Pneumococcal Infections Population Positioning Attribute Poverty Pregnancy Pregnant Women Premature Infant Preparation Prevalence Prevention Prevention Protocols Prevention approach Prevention program Prevention strategy Principal Investigator Probability Problem-Based Learning Procedures Process Productivity Professional counselor Protocols documentation Province Psychiatry Psychologist Psychology Public Health Public Health Informatics Public Health Nurses Public Health Nursing Public Health Schools Public Health Students Publishing Purpose Qualifying Quality of Care Randomized Randomized Clinical Trials Randomized Controlled Clinical Trials Rate Recommendation Recording of previous events Records Recruitment Activity Rehabilitation therapy Rehydrations Religion Reporting Reproductive Health Research Research Activity Research Ethics Research Ethics Committees Research Infrastructure Research Personnel Research Priority Research Project Grants Research Proposals Research Subjects Residual state Resources Review Committee Review, Systematic (PT)Rights Role Rural Rural Health Rural Health Centers Rural Population Safety Scholarship Schools Science Scientist Score Screening procedure Services Severities Side Site Social Marketing Social Responsibility Social Sciences Social Welfare Social status Societies Sociology Sodium Hypochlorite Source Source Code Specialist Standards of Weights and Measures Stigmata Stress Students Supplementation Surgeon Sustainable Development Sweden System Techniques Technology Telephone Testing Therapeutic Time Today Traditional Birth Attendants Training Training Programs Transportation Travel Trust Tuberculosis Uncertainty United States United States National Institutes of Health Universities Ursidae Family Vaccination Vaccines Vertical Disease Transmission Victoria Austrailia Village Health Workers Viola Virus Visit Vitamin A Vulnerable Populations Wages Water Weaning Week Weight Width Woman Women&apos s Health Wool Work World Bank Writing Zambia Zinc abstracting antiretroviral therapy base care systems career chlorination clinical application clinical research site cohort college community based service computer science data management design disorder prevention drinking water driving force editorial expectation experience feeding fetal follow-up forest health care delivery human subject improved indexing infancy infant nutrition innovation instrument interest international center medical schools medical specialties member mortality motivational enhancement therapy multidisciplinary novel nutrition open source pediatric department pediatrician peer post-doctoral training postnatal prenatal prevent professor progenitor programs prospective protocol development research study residence respiratory school health size social social stigma sociologist success surfactant symposium therapy adherence treatment program urban area ward wasting water sampling water treatment

项目摘要

DESCRIPTION (provided by applicant): We propose to develop a Global Network for Women's and Children's Health Research site in Eldoret, Kenya. This East African site will be a joint partnership between Indiana University and Moi University School of Medicine, one of two medical schools in Kenya. The 17 year partnership of Moi University and Indiana University will bring unique strengths to the Global Network. These include an established administrative, scientific, and collegial relationship between the institutions, an extensive research infrastructure that includes an established network of rural health centers from which to draw subjects, a well functioning Kenyan Institutional Review Board with a OHRP Assurance number, and an established expanding coverage of subjects by an electronic medical record. The Senior Foreign Investigator is Dean of the Medical School, and has well established relationships with high level Ministry of Health personnel. A large number of other Moi University investigators with expertise in Obstetrics, Public Health, Nutrition, Epidemiology, and Behavioral Sciences are also eager to join the Global Network. US based expertise is also present in Obstetrics, Biostatistics, and Bioethics. We propose to the Network a cluster randomized protocol evaluating the efficacy of both Community Mobilization for the use of a Safe Water System (SWS) and for zinc supplementation in partially weaned infants less than 6 months of age. The SWS includes specially designed narrow neck water storage containers and point of use home chlorination using dilute sodium hypochlorite. Hypotheses to be tested are that 1.) Community Mobilization will result in sustained, consistent use of point of use water treatment 2.) This will lead to a decreased incidence of diarrhea in less than 6 month old infants. 3.) Zinc supplementation beginning at partial weaning will lead to a further decrease in the incidence of diarrhea in these infants. 4.) Growth will be improved and failure to thrive decreased in experimental groups. 5.) All cause mortality in >6 month old infants will be decreased in experimental groups. If efficacy is shown, these are highly sustainable interventions that will improve the health and well being of vulnerable infants.

描述（由申请人提供）：我们建议在肯尼亚埃尔多雷特建立一个全球妇女和儿童健康研究网络网络。这个东非站点将是印第安纳大学和莫伊大学医学院（肯尼亚两所医学院之一）之间的联合合作项目。莫伊大学和印第安纳大学长达 17 年的合作关系将为全球网络带来独特的优势。其中包括机构之间已建立的行政、科学和学院关系，广泛的研究基础设施，其中包括已建立的农村卫生中心网络（可从中抽取受试者），运作良好且具有 OHRP 保证编号的肯尼亚机构审查委员会，以及已建立的通过电子病历扩大受试者的覆盖范围。高级外国研究员是医学院院长，与卫生部高层人员建立了良好的关系。莫伊大学在产科、公共卫生、营养学、流行病学和行为科学方面拥有专业知识的许多其他研究人员也渴望加入全球网络。美国的专业知识还涉及产科、生物统计学和生物伦理学。我们向网络提出一项整群随机方案，评估社区动员对于使用安全饮水系统 (SWS) 和对 6 个月以下部分断奶婴儿补充锌的效果。 SWS 包括专门设计的窄颈储水容器和使用稀次氯酸钠的家庭使用点氯化装置。要测试的假设是 1.) 社区动员将导致持续、一致地使用使用点水处理 2.) 这将导致 6 个月以下婴儿的腹泻发生率降低。 3.) 从部分断奶开始补充锌将进一步降低这些婴儿腹泻的发生率。 4.) 实验组的生长会得到改善，生长障碍会减少。 5.) 实验组中 6 个月以上婴儿的全因死亡率将会降低。如果显示出有效性，这些都是高度可持续的干预措施，将改善弱势婴儿的健康和福祉。