The role of estradiol in the menopause

雌二醇在更年期中的作用

• 批准号: 7478373
• 负责人: ERIN S LEBLANC
• 金额: $ 13.08万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7478373
• 关键词: Affect; Area; Benefits and Risks; Brain; Candidate Disease Gene; Clinical Research; Cognition; Cognitive; Development; Endocrinology; Environment; Epidemiology; Equipment; Estradiol; Estrogen Replacement Therapy; Estrogen Replacements; Estrogens; Event; Genes; Genetic; Genetic Variation; Goals; Gonadal Steroid Hormones; Health Sciences; Hormonal; Hot flushes; Impaired cognition; Individual; Laboratories; Lead; Life; Measures; Menopausal Symptom; Menopausal hot flushes; Menopause; Metabolism; Monitor; Moods; Neurosciences; Observational Study; Oregon; Perimenopause; Phenotype; Proteins; Randomized Controlled Trials; Range; Research; Research Project Grants; Research Training; Role; Sleep; Sleep disturbances; Supplementation; Symptoms; Time; Training; Universities; Variant; Vasomotor; Woman; Women' s Group; Women' s Health; career; cognitive change; disturbance in affect; experience; foot; genetic epidemiology; improved; instrument; medical schools; programs; response

DESCRIPTION (provided by applicant): Candidate's Statement: The candidate has extensive training and research experience in women's health, endocrinology, and epidemiology. Her immediate goals are to expand her field of expertise into neuroscience and genetic epidemiology and to solidify her training in clinical research. Ultimately, she wants to launch an independent research career in the field of sex hormones and the menopause. To accomplish her goals, she will attend formal and informal didactics in neuroscience, genetics, and clinical research and implement the studies described under the research section. Environment: Oregon Health Sciences University (OHSU) is the only medical school in the state, and has a strong tradition of research and training. This study will utilize the OHSU General Clinical Research Center, which is a 12,500 square foot facility that includes a Core Laboratory (with a wide array of analytical instruments including specialized genetics equipment), bionutrition unit, and computing center. Research Project: The overall goal is to characterize the hormonal, cognitive, and somatic changes that occur during the menopausal transition and during estrogen supplementation. In Aim 1, we will conduct an observational study of perimenopausal women to determine the relationship between symptoms, sleep, mood, and cognition and estradiol levels and change in estradiol levels. In Aim 2, we will perform a randomized controlled trial to differentiate whether the changes in cognition, sleep, and mood that occur with estrogen replacement are due to menopausal symptom relief. In Aim 3, we will seek associations between protein variants (functional gene sequence variations) involved in estradiol synthesis and metabolism and action and menopausal events (including estradiol levels, symptoms, sleep, mood, cognition, and response to estrogen supplementation).

描述（由申请人提供）： 候选人声明： 候选人在妇女健康、内分泌学和流行病学方面拥有丰富的培训和研究经验。她的近期目标是将她的专业领域扩展到神经科学和遗传流行病学，并巩固她在临床研究方面的培训。最终，她想在性激素和更年期领域开展独立的研究生涯。为了实现她的目标，她将参加神经科学、遗传学和临床研究方面的正式和非正式教学，并实施研究部分所述的研究。环境：俄勒冈健康科学大学（OHSU）是该州唯一的医学院，拥有悠久的研究和培训传统。这项研究将利用 OHSU 普通临床研究中心，该中心占地 12,500 平方英尺，包括一个核心实验室（拥有各种分析仪器，包括专门的遗传学设备）、生物营养单元和计算中心。研究项目：总体目标是表征绝经过渡期间和雌激素补充期间发生的荷尔蒙、认知和躯体变化。在目标 1 中，我们将对围绝经期女性进行观察性研究，以确定症状、睡眠、情绪和认知与雌二醇水平之间的关系以及雌二醇水平的变化。在目标 2 中，我们将进行一项随机对照试验，以区分雌激素替代引起的认知、睡眠和情绪变化是否是由于更年期症状缓解所致。在目标 3 中，我们将寻找参与雌二醇合成、代谢和作用的蛋白质变异（功能基因序列变异）与更年期事件（包括雌二醇水平、症状、睡眠、情绪、认知和对雌激素补充的反应）之间的关联。