New Neurons in the Adult Amygdala

成人杏仁核中的新神经元

• 批准号: 8260196
• 负责人: ZUOXIN WANG
• 金额: $ 35.96万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8260196
• 关键词: Adult; Affect; American; Amygdaloid structure; Antimitotic Agents; Anxiety; Area; Attention; Beds; Behavioral; Biological Models; Birth; Brain; Brain region; Bromodeoxyuridine; Cell Proliferation; Cell Survival; Cells; Cessation of life; Characteristics; Cues; Data; Dopamine; Exposure to; Female; Injection of therapeutic agent; Investigation; Label; Laboratories; Light; Mediating; Microtinae; Microtus; Nerve Degeneration; Nervous system structure; Neurodegenerative Disorders; Neurons; Olfactory Pathways; Oxytocin; Parahippocampal Gyrus; Pathology; Phenotype; Physiological; Play; Proliferating; Proliferation Marker; Regulation; Rodent; Role; Scientist; Sensory Process; Social Behavior; Social Environment; Social Interaction; Social isolation; Stimulus; Structure; Testing; Time; Tracer; Vasopressins; Work; adult neurogenesis; critical period; dentate gyrus; design; experience; immunocytochemistry; lateral ventricle; male; neural circuit; neurochemistry; neurogenesis; novel; olfactory bulb; prairie vole; public health relevance; receptor; social; social attachment; steroid hormone; subventricular zone; vomeronasal organ

DESCRIPTION (provided by applicant): Adult-generated cells are found in the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the rostral lateral ventricle in mammalian brains. Scientists have focused on these two brain areas to characterize the factors mediating adult neurogenesis, determine the phenotypes of the new cells, and reveal their potential functional significance. While new cells are also found in several other brain areas, little is known about the morphological characteristics, neurochemical phenotypes, and functions of these new cells. In this proposal, we focus on the amygdala - a brain area which is important for sensory processing, information integration, and the modulation of a variety of physiological and behavioral functions, and which contains adult-generated cells but has received little attention in the neurogenesis field. We will use the socially monogamous female prairie voles (Microtus ochrogaster) as our model system as the vole's amygdala contained adult-generated cells, their rates of proliferation were facilitated by social interactions and diminished by social isolation, and treatment of an antimitotic drug reduced new neurons in the amygdala and inhibited social attachment formation. Our working hypothesis is that social/chemosensory stimuli from a conspecific affect amygdala neurogenesis in a stimulus-, time- and area-specific manner, adult-generated amygdala neurons integrate into the existing neural circuitry, express certain neurochemical phenotypes, and play a functional role in mediating social behavior. To test this hypothesis, we will focus on the amygdala to (1) examine the role of chemosensory stimuli in cell proliferation, (2) reveal the critical period for such social/chemosensory experience to enhance cell survival, (3) determine the neuromorphological and neurochemical characteristics of these new cells, (4) and examine the role of new amygdala cells in social behavior. Data from this study will shed light into amygdala adult neurogenesis and provide a starting point for the investigation of the amygdala neurogenic potential to be used as treatment for neurodegenerative-related amygdala deficits. PUBLIC HEALTH RELEVANCE: Project Narrative Newly-generated cells in the adult mammalian brains (adult neurogenesis) have the potential to be used as treatment for neurodegenerative diseases. Here we propose to examine adult neurogenesis in the amygdala in the socially monogamous prairie voles to test the hypothesis that social environment affects adult neurogenesis in the amygdala, and newly-generated amygdaloid cells integrate into the neural circuitry and play a functional role in the regulation of social behaviors.

描述（由申请人提供）：成年产生的细胞在哺乳动物大脑中的海马齿状回（DG）和鼻侧心室的室内室内（SVZ）中发现。科学家专注于这两个大脑区域，以表征介导成人神经发生的因素，确定新细胞的表型并揭示其潜在的功能意义。尽管在其他几个大脑区域也发现了新细胞，但对这些新细胞的形态特征，神经化学表型和功能知之甚少。在此提案中，我们专注于杏仁核 - 大脑区域，对于感官处理，信息整合以及对多种生理和行为功能的调节很重要，其中包含成人产生的细胞，但在神经发生领域中几乎没有关注。我们将使用社会上的女性草原田鼠（Microtus ochrogaster）作为模型系统，因为Vole的杏仁核包含成人生成的细胞，它们的增殖速度通过社交互动来促进，并通过社交隔离，抗密拟核药物减少的新神经元在Amyygdala和Amyygdala和Social in Amyygdala and Social snecration降低。我们的工作假设是，来自同种的社会/化学感应刺激以刺激，时间和区域特异性的方式影响杏仁核神经发生，成人生成的杏仁核神经元整合到现有的神经回路中，表达某些神经化学表型，并在某些神经化学表型中表现出功能的作用。 To test this hypothesis, we will focus on the amygdala to (1) examine the role of chemosensory stimuli in cell proliferation, (2) reveal the critical period for such social/chemosensory experience to enhance cell survival, (3) determine the neuromorphological and neurochemical characteristics of these new cells, (4) and examine the role of new amygdala cells in social behavior.这项研究的数据将阐明杏仁核成人神经发生，并为研究杏仁核神经源性潜力提供了一个起点，以作为神经退行性相关的杏仁核缺陷的治疗。 公共卫生相关性： 成年哺乳动物大脑中的项目叙事新生成的细胞（成人神经发生）有可能用作神经退行性疾病的治疗。在这里，我们建议检查社会一夫一妻制的杏仁核中的成年神经发生，以检验以下假设：社会环境影响杏仁核中的成人神经发生，新生成的杏仁糖细胞在神经电路中积累并在社交行为的调节中起作用。