Stress, social buffering, and oxytocin regulation

压力、社交缓冲和催产素调节

基本信息

批准号：
10064088
负责人：
ZUOXIN WANG
金额：
$ 37.41万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-09 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10064088
关键词：
Agonist Animal Model Anxiety Anxiety Disorders Attenuated Behavior Behavioral Bilateral Brain Buffers Cannulas Clinical Treatment Confocal Microscopy Corticosterone Corticotropin-Releasing Hormone Data Dose Exposure to Female Gene Expression Health Home Hormonal Human Hypothalamic structure Immobilization Impairment Implant Individual Investigation Knowledge Mammals Mediating Mental Depression Mental Health Mental disorders Microtus Neurobiology Neuropeptides Outcome Oxytocin Pair Bond Partner in relationship Personal Satisfaction Pharmacology Physiological Plant Roots Play Psyche structure Psychological Stress Receptor Gene Recovery Regulation Reporting Risk Role Sex Differences Siblings Social Behavior Social Interaction Social support Stimulus Stress Stress and Coping Testing Therapeutic Vasopressins affiliative behavior anxiety-like behavior behavior test biobehavior biological adaptation to stress biological systems gamma-Aminobutyric Acid hypothalamic-pituitary-adrenal axis immunocytochemistry improved in vivo insight male neurobiological mechanism neurochemistry neuromechanism paraventricular nucleus physical conditioning prairie vole protein expression psychological distress receptor response sex social social attachment stress management

项目摘要

Project Summary/Abstract Psychological stress can induce activation of the hypothalamic-pituitary-adrenal (HPA) axis, impairing the function of multiple biological systems and posing a risk to mental and physical health. In contrast, positive social interactions, especially social support from deeply rooted social bonds, can ameliorate stress-induced mental, physiological, and behavioral deficits and improve an individual's overall well-being—a phenomenon known as social buffering [1, 2]. Such social buffering effects have been described in both human [3-5] and animal models [6, 7]. Although we have begun to understand the neuromechanisms underlying biobehavioral responses to psychological stress, little is known about the neuromechanisms by which social support buffers the stress response [1]. This is largely due to the difficulties inherent in studying neurobiological mechanisms in humans as well as a lack of appropriate animal models to assess the effects of social buffering. Recently, the socially monogamous prairie vole (Microtus ochrogaster) has emerged as an animal model to study the neurobiology of social behavior. In prairie voles, mating induces pair bonding, which is regulated by several neurochemicals including oxytocin (OT), vasopressin (AVP), corticotrophin releasing hormone (CRH), and gamma-aminobutyric acid (GABA) [8, 9]. Pair bonding reduces stress-induced anxiety-like behavior by attenuating the action of the HPA axis [10]. Interactions with the partner also promote the release of central OT [11], which plays a role in attenuating the biobehavioral response to stress in female voles [12]. Using this unique animal model, we propose, in Specific Aim 1, to examine how social buffering by a sibling cage mate or a bonding partner attenuates immobilization (IMO)-induced stress responses in male and female prairie voles. We will examine the effects of social buffering on (1) anxiety-like, depression-like, and affiliative behaviors, (2) circulating levels of corticosterone (CORT), (3) CRH, OT, AVP, GABA, and their receptors gene and protein expression in the paraventricular nucleus of the hypothalamus (PVN), and (4) neurochemical release in the PVN during IMO and social buffering. In Specific Aim 2, we will perform pharmacological manipulations with behavioral testing to examine the functional role of PVN OT, and its interactions with GABA, CRH and AVP, in the social buffering of the stress response. In Specific Aim 3, we will examine the neurochemical and physiological involvement of PVN neuromicrocircuitry in the regulation of social buffering. Data from this study will not only enhance our understanding of sex differences in the neurochemical regulation of social buffering of stress responses but also further establish a much needed animal model for such investigation.

项目摘要/摘要心理压力会引起下丘脑 - 垂体 - 肾上腺（HPA）轴的激活，从而损害了多种生物系统的功能，并为身心健康带来风险。相反，积极社会互动，尤其是根深蒂固的社会纽带的社会支持，可以改善压力引起的精神，身体和行为定义并改善个人的整体福祉 - 这一现象被称为社会缓冲[1，2]。在人类[3-5]和动物模型[6，7]。尽管我们已经开始了解生物行为的神经力学对心理压力的反应，对社会支持缓冲的神经力学知之甚少压力反应[1]。这主要是由于难以研究神经生物学机制人类以及缺乏适当的动物模型来评估社会缓冲的影响。最近，社会一夫一妻制的草原Vole（Microtus ochrogaster）已成为一种动物模型，以研究社会行为的神经生物学。在草原田鼠中，交配会影响对键合，这受到几个神经化学物质，包括氧（OT），加压素（AVP），皮质营养蛋白释放果（CRH）和 γ-氨基丁酸（GABA）[8，9]。配对结合通过减弱HPA轴的作用[10]。与合作伙伴的互动还促进了中央OT的发布 [11]，它在减轻雌性田鼠压力的生物行为反应中起作用[12]。使用此在特定的目标1中，我们建议独特的动物模型，以研究兄弟姐妹笼子伴侣或一个粘合伙伴减弱了固定化（IMO）诱导的男性和女性草原田鼠的压力反应。我们将研究社交缓冲对（1）类似动画，类似抑郁和会员行为的影响，（2）循环水平的皮质酮（CORT），（3）CRH，OT，AVP，GABA及其受体基因，以及下丘脑（PVN）的副脑核中的蛋白质表达，（4）神经化学释放 IMO和社交缓冲期间的PVN。在特定目标2中，我们将执行药物操纵进行行为测试以检查PVN OT的功能作用及其与GABA，CRH和 AVP，在压力反应的社会缓冲中。在特定目标3中，我们将检查神经化学和 PVN神经循环的生理参与社会缓冲调节。来自此的数据研究不仅会增强我们对社会神经化学调节中性别差异的理解压力反应的缓冲，但也进一步建立了急需的动物模型以进行此类投资。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Transcriptomic analysis of paternal behaviors in prairie voles.

DOI：
10.1186/s12864-022-08912-y
发表时间：
2022-10-01
期刊：
BMC genomics
影响因子：
4.4
作者：
通讯作者：

Transcription and DNA methylation signatures of paternal behavior in hippocampal dentate gyrus of prairie voles.

DOI：
10.1038/s41598-023-37521-2
发表时间：
2023-07-07
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Waddell, Nicholas J. J.;Liu, Yan;Chitaman, Javed M. M.;Kaplan, Graham J. J.;Wang, Zuoxin;Feng, Jian
通讯作者：
Feng, Jian

Social isolation alters behavior, the gut-immune-brain axis, and neurochemical circuits in male and female prairie voles.

社会隔离改变了雄性和雌性草原田鼠的行为、肠道-免疫-大脑轴和神经化学回路。

DOI：
10.1016/j.ynstr.2020.100278
发表时间：
2020-11
期刊：
Neurobiology of stress
影响因子：
5
作者：
Donovan M;Mackey CS;Platt GN;Rounds J;Brown AN;Trickey DJ;Liu Y;Jones KM;Wang Z
通讯作者：
Wang Z

Effects of pair bonding on parental behavior and dopamine activity in the nucleus accumbens in male prairie voles.