Enhancing HIV Risk Reduction Among Indian Women with Risky Husbands

加强降低丈夫风险较高的印度女性的艾滋病毒风险

基本信息

批准号：
8337503
负责人：
Anita Raj
金额：
$ 14.58万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-30 至 2011-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8337503
关键词：
Enhancing HIV Risk Reduction Among

项目摘要

DESCRIPTION (provided by applicant): The purpose of our proposed study is to develop and test the feasibility and acceptability of the RHANI Wives intervention, a multi-session primary HIV prevention program for at-risk Indian wives. The RHANI Wives intervention will be adapted from HIV-IP, a U.S. women's HIV intervention with demonstrated effectiveness in promoting participants' sexual communication and condom use with main male partners. The project will be conducted in 2 phases. Phase 1 will involve adaptation and refinement of the RHANI Wives model and evaluation tools, based on formative research conducted with the target population and their affiliates, as well as a single cycle involving pilot testing a truncated version of the RHANI Wives model. Phase 2 of the study will involve assessment of the feasibility and acceptability of the RHANI Wives HIV prevention intervention for at-risk Indian wives via a cluster randomized trial conducted with 300 eligible women recruited from 12 neighborhood clusters within a single Mumbai slum community. The evaluation will involve assessment of intervention effects on a proximal likely safer sex-mediating behavior, marital sexual communication, via survey at baseline, posttest (6 weeks post-baseline) and at 3 month follow-up (4.5 months post-baseline), to determine the impact of the intervention versus the control on this variable. Exploratory analyses will be conducted to estimate the effect of the intervention on outcomes necessary for examination in an efficacy trial, women's marital condom use and STI. A process evaluation will also be undertaken to ensure quality control and to document program processes and participant response to program. Findings from this study will be used to support development of an NIH R01 for a larger efficacy trial of the RHANI Wives program.

描述（由申请人提供）：我们提出的研究的目的是开发和测试 RHANI Wives 干预措施的可行性和可接受性，这是一项针对高危印度妻子的多阶段艾滋病毒初级预防计划。 RHANI Wives 干预措施将改编自 HIV-IP，这是一项美国妇女艾滋病毒干预措施，在促进参与者与主要男性伴侣的性沟通和安全套使用方面已被证明有效。该项目将分两个阶段进行。第一阶段将根据对目标人群及其附属机构进行的形成性研究，以及涉及试点测试 RHANI Wives 模型截短版本的单个周期，对 RHANI Wives 模型和评估工具进行调整和完善。该研究的第二阶段将通过一项整群随机试验，评估 RHANI Wives HIV 预防干预措施对高危印度妻子的可行性和可接受性，该试验从孟买一个贫民窟社区的 12 个邻里集群中招募了 300 名符合资格的妇女。评估将包括通过基线调查、后测（基线后 6 周）和 3 个月随访（基线后 4.5 个月）评估对最近可能更安全的性中介行为、婚姻性沟通的干预效果，以确定干预与控制对该变量的影响。将进行探索性分析，以评估干预措施对功效试验、女性婚内安全套使用和性传播感染所需检查结果的影响。还将进行过程评估，以确保质量控制并记录计划流程和参与者对计划的反应。这项研究的结果将用于支持 NIH R01 的开发，以进行 RHANI Wives 计划的更大规模功效试验。