Purchase of a 400 MHz Multi-Nuclear NMR Spectrometer

购买 400 MHz 多核核磁共振波谱仪

• 批准号: 7385164
• 负责人: Joseph E Rice
• 金额: $ 35.14万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385164
• 关键词: Aging; Antineoplastic Agents; Area; Biological Factors; Chemical Structure; Chemopreventive Agent; Development; Drug Design; Funding; Malignant Neoplasms; Methodology; Nuclear; Pathway interactions; Pharmaceutical Chemistry; Pharmacologic Substance; Pharmacology and Toxicology; Pharmacy Schools; Plants; Preventive; Research; Research Personnel; Research Project Grants; Resolution; Science; Series; Services; Structure; Support of Research; United States National Institutes of Health; design; drug isolation; instrument; novel; programs; tool

DESCRIPTION (provided by applicant): The objective of this proposal is to obtain funding for the purchase a Varian 400 MHz multi-nuclear NMR spectrometer as a replacement for an aging Varian Gemini 200 MHz instrument. The current spectrometer has been in continuous service since September 1988. Varian will no longer support the Gemini series of instruments. The new instrument will be the only NMR spectrometer in the Ernest Mario School of Pharmacy and will serve the needs of approximately 35-40 researchers from the Graduate Programs in Medicinal Chemistry, Pharmaceutical Science, and Pharmacology and Toxicology. These researchers have no routine access to other NMR facilities on campus. This instrument will be used to support research efforts on 13 NIH funded projects. These projects are focused largely on the design and synthesis of novel heterocyclic and macrocyclic anticancer agents, the development of new methodology for the synthesis of pharmaceutical agents, the isolation and structure elucidation of natural products having potential as anticancer or chemopreventive agents, and on the determination of the mechanisms of action of chemopreventive agents. All of these projects require ready access to a high resolution NMR spectrometer for structure determination. The Varian 400 MHz multi-nuclear NMR spectrometer for which funding is being requested will greatly enhance the cutting edge research efforts of the major users of this instrument in the areas of novel anticancer drug design, synthesis, and discovery. The research projects described in this proposal are largely targeted towards the synthesis and identification of novel anticancer agents with the potential for development into clinically-useful drugs, the isolation and structure elucidation of bioactive compounds from plants, and the determination of metabolites and activation pathways of naturally-occurring cancer-preventive agents. The availability of a high resolution multi-nuclear NMR spectrometer is an essential tool for determining the chemical structures of these compounds and advancing these research efforts.

描述（由申请人提供）：本提案的目的是获得资金购买瓦里安 400 MHz 多核核磁共振波谱仪，以替代老化的瓦里安 Gemini 200 MHz 仪器。目前的光谱仪自 1988 年 9 月以来一直持续使用。瓦里安将不再支持 Gemini 系列仪器。该新仪器将是欧内斯特·马里奥药学院唯一的核磁共振波谱仪，并将满足药物化学、药物科学、药理学和毒理学研究生项目约 35-40 名研究人员的需求。这些研究人员无法例行访问校园内的其他核磁共振设施。该仪器将用于支持 13 个 NIH 资助项目的研究工作。这些项目主要集中于新型杂环和大环抗癌剂的设计和合成、药物合成新方法的开发、具有抗癌或化学预防剂潜力的天然产物的分离和结构阐明，以及确定化学预防剂的作用机制。所有这些项目都需要随时使用高分辨率核磁共振波谱仪来确定结构。正在申请资助的瓦里安 400 MHz 多核核磁共振波谱仪将极大地增强该仪器主要用户在新型抗癌药物设计、合成和发现领域的前沿研究工作。该提案中描述的研究项目主要针对具有开发成临床有用药物潜力的新型抗癌药物的合成和鉴定、植物中生物活性化合物的分离和结构阐明以及代谢物和激活途径的测定。天然存在的癌症预防剂。高分辨率多核核磁共振波谱仪的可用性是确定这些化合物的化学结构和推进这些研究工作的重要工具。