Universite de Montreal IBD Genetics Research Center

蒙特利尔大学 IBD 遗传学研究中心

• 批准号: 8146126
• 负责人: John D. Rioux
• 金额: $ 27.39万
• 依托单位: MONTREAL HEART INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2012-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146126
• 关键词: 19p; Adolescent; Affect; Age; American; Biological; Biopsy; Cell Line; Cells; Cellular Immunology; Cellular biology; Chronic; Chronic Disease; Clinical; Clinical Management; Colitis; Collaborations; Colon; Complex Genetic Trait; Crohn' s disease; Data; Data Coordinating Center; Digestive System Disorders; Disease; Doctor of Medicine; Doctor of Philosophy; Gastrointestinal tract structure; Genes; Genetic; Genetic Markers; Genetic Research; Genetic Risk; Genetic Transcription; Genetic Variation; Goals; Heart; Hereditary Disease; Individual; Inflammatory; Inflammatory Bowel Diseases; Institutes; Knowledge; Lead; Lymphocyte; Medical; Modeling; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; Operative Surgical Procedures; Pathogenesis; Patients; Persons; Phenotype; Play; Predisposition; Preventive Intervention; Principal Investigator; Province; Quebec; RNA Interference; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Selection for Treatments; Staging; Study Subject; Susceptibility Gene; Testing; Therapeutic Intervention; Ulcerative Colitis; Universities; Work; arm; base; cohort; disorder risk; disorder subtype; genetic risk factor; genome-wide; improved; meetings; novel; programs; protein expression; repository; response; sample collection; success; young adult

DESCRIPTION (provided by applicant): This application is submitted in response to RFA DK-06-504 to continue the efforts of the NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) and our role as a Genetic Research Center (GRC). Crohn's disease (CD) and ulcerative colitis (UC) are two common chronic inflammatory diseases of the gastrointestinal tract, collectively known as the inflammatory bowel diseases (IBD). It is estimated that as many as one million Americans are affected with these debilitating diseases. IBD may occur in people of all ages, but it is primarily a disease that arises in adolescents and young adults. Currently there is no known cure for IBD. Over the last five years, a number of IBD genes (CARD15, IBD5, MYO9B, and IL23R) have been identified, but these do not explain all of the genetic risk to IBD. One of the major challenges in complex trait genetics is having sufficiently powered studies. In order to meet this challenge, the NIDDK has supported the creation of the North American IBDGC. This Consortium consists of six GRCs and one data-coordinating center (DCC). The primary goals of this Consortium have been to collect a large and extremely well phenotyped cohort of IBD patients and matched controls and to apply the latest analytical and technological approaches for the discovery of risk factors that influence an individual's predisposition to developing CD or UC. The Universit¿ de Montr¿al GRC (UMGRC) has played and will continue to play an important role in the recruitment of study subjects, collection of samples and information for the NIDDK public IBD repository, and will lead and participate in the studies aimed to: (1) identify genetic risk factors for IBD, (2) understand how these factors can lead to IBD, and (3) determine how this knowledge can improve clinical management of patients with these chronic diseases. IBD is a chronic inflammatory disease of the digestive tract that primarily affects young people and is characterized by long-term illness and the need for potent medical therapy and substantial surgical therapy. Our work will identify IBD genes and is expected to help: (1) identify persons at risk for disease, (2) predict disease course, (3) aid in selection of treatment, (4) understand the biological mechanisms that lead to IBD such that novel preventive and therapeutic interventions can be developed. Advances in IBD gene identification and methodologic approaches may also be applicable to other common genetic disorders.

描述（由申请人提供）：本申请是针对 RFA DK-06-504 提交的，旨在继续 NIDDK 炎症性肠病遗传学联盟 (IBDGC) 的努力以及我们作为遗传研究中心 (GRC) 的作用。溃疡性结肠炎（UC）是两种常见的胃肠道慢性炎症性疾病，统称为炎症性肠病（IBD）。据估计，有多达一百万美国人患有这些使人衰弱的疾病，这些疾病可能发生在各个年龄段的人中，但这种疾病主要发生在青少年和年轻人中，目前尚无已知的治疗方法。过去五年，许多 IBD 基因（CARD15、IBD5、MYO9B 和 IL23R）已被鉴定，但这些并不能解释 IBD 的所有遗传风险。 复杂性状遗传学的主要挑战之一是拥有足够有力的研究，为了应对这一挑战，NIDDK 支持创建北美 IBDGC，该联盟由六个 GRC 和一个数据协调中心 (DCC) 组成。该联盟的主要目标是收集大量表型极其良好的 IBD 患者和匹配对照队列，并应用最新的分析和技术方法来发现影响个体罹患 IBD 倾向的风险因素。 CD 或 UC。德蒙特尔al GRC (UMGRC) 在招募研究对象、为 NIDDK 公共 IBD 存储库收集样本和信息方面已经并将继续发挥重要作用，并将领导和参与旨在：（1）识别遗传IBD 的危险因素，(2) 了解这些因素如何导致 IBD，以及 (3) 确定这些知识如何改善这些慢性病患者的临床管理。 IBD 是一种慢性消化道炎症性疾病，主要影响年轻人，其特点是长期患病，需要有效的药物治疗和大量的手术治疗，我们的工作将识别 IBD 基因，预计将有助于：(1)。识别有患病风险的人，(2) 预测病程，(3) 帮助选择治疗方法，(4) 了解导致 IBD 的生物学机制，以便开发新的预防和治疗干预措施。方法论方法也可能适用于其他常见的遗传性疾病。