The Environmental Determinants of Diabetes in Young (TEDDY)

青少年糖尿病的环境决定因素 (TEDDY)

基本信息

批准号：
8094457
负责人：
OLLI G SIMELL
金额：
$ 29.24万
依托单位：
HOSPITAL DISTRICT OF SOUTHWEST FINLAND
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-04-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8094457
关键词：
15 year old 25-hydroxyvitamin D 4 year old Address Affect Age of Onset Age-Months Alleles Ancillary Study Antibodies Antioxidants Ascorbic Acid Autoantibodies Autoimmunity Bacterial Infections Biological Biological Markers Birth Weight Blood Blood specimen Breast Feeding Carotenoids Cattle Cell membrane Cereals Child Childhood Clinical Cohort Studies Collaborations Contracts Data Data Collection Data Coordinating Center Data Quality Development Diabetes Mellitus Diabetic Ketoacidosis Diagnosis Diet Records Dietary Factors Disease Education Enrollment Enterovirus Environmental Exposure Environmental Risk Factor Epidemiologic Studies Epidemiology Erythrocytes Etiology Europe Event Exhibits Exposure to Family Fatty Acids Feces Finland First Degree Relative Frequencies Funding General Population Genes Genetic Genetic Polymorphism Genomics Genotype Gluten Goals HLA-DR Antigens Hour Household Hypersensitivity Immunization Incidence Infection Infectious Agent Insulin Insulin-Dependent Diabetes Mellitus Intake Joints Laboratories Lead Life Liquid substance Milk Molecular Mimicry Monitor Neonatal Screening Nested Case-Control Study Newborn Infant Nitrates Omega-3 Fatty Acids Outcome Study Participant Pathogenesis Patients Performance Plasma Cells Population Pre-Eclampsia Pregnancy Protocols documentation Psychological Stress Psychosocial Factor Publishing Questionnaires RNA Research Design Research Personnel Risk Rotavirus Sampling Scientist Screening procedure Selenium Serum Severities Specimen Stress Structure Study Subject Testing Time Toxin United States Virus Vitamin D Vitamin E Work Zinc alpha Tocopherol base design dietary constituent drinking water endocrine pancreas development follow-up gamma-Tocopherol gene environment interaction genetic analysis high risk high risk infant improved infancy insight islet lissamine rhodamine B novel pet animal prevent programs prospective sample collection time use

项目摘要

DESCRIPTION (provided by applicant): This limited competition renewal application is for the Turku/Finland Clinical Center of The Environmental Determinants of Diabates in the Young (TEDDY) study. The primary objective of this multi-center, multi- national epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of islet autoimmunity and type 1 diabates mellitus (T1D). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression, or which provide protection from the development of T1D will also be identified. TEDDY is an observational cohort study in which newborns who are less than 4.5 months of age and have high risk HLA genotypes and come from the general population, or carry HLA risk alleles and are first-degree relatives of patients affected with T1D will be enrolled. Six Clinical Centers in the United States and Europe will screen 361,588 newborns of which it is anticipated that 17,804 will be eligible for enrollment, with just over 7,800 followed. Recruitment started in September 2004 and will continue until December 31, 2009. Participants will be followed to the age of 15 years. Identification of such etiologically important factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1D.

说明（由申请人提供）：此有限竞赛续展申请适用于图尔库/芬兰青年糖尿病环境决定因素 (TEDDY) 研究临床中心。这项多中心、多国家流行病学研究的主要目的是确定与胰岛自身免疫和 1 型糖尿病 (T1D) 风险增加相关的传染源、饮食因素或其他环境暴露。还将确定影响特定表型表现的因素，例如发病年龄或进展速度，或提供保护以防止 T1D 发展的因素。 TEDDY 是一项观察性队列研究，其中年龄小于 4.5 个月且具有高风险 HLA 基因型且来自普通人群的新生儿，或携带 HLA 风险等位基因且是 1 型糖尿病患者的一级亲属的新生儿将被纳入研究。美国和欧洲的 6 个临床中心将对 361,588 名新生儿进行筛查，预计其中 17,804 名新生儿符合入组条件，其余 7,800 名新生儿将继续接受随访。招募工作于2004年9月开始，将持续到2009年12月31日。参与者将被跟踪至15岁。识别这些重要的病因因素将有助于更好地了解疾病发病机制，并产生预防、延迟或逆转 T1D 的新策略。