The Environmental Determinants of Diabetes in Young (TEDDY0

年轻人糖尿病的环境决定因素 (TEDDY0

基本信息

批准号：
7492544
负责人：
OLLI G SIMELL
金额：
$ 108万
依托单位：
HOSPITAL DISTRICT OF SOUTHWEST FINLAND
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-04-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7492544
关键词：
25-hydroxyvitamin D Address Affect Age Age of Onset Age-Months Age-Years Alleles Ancillary Study Antibodies Antioxidants Ascorbic Acid Ascorbic acid/Selenium Autoantibodies Autoimmunity Bacterial Infections Biological Biological Markers Birth Weight Blood Blood specimen Breast Feeding Carotenoids Case-Control Studies Cattle Cell membrane Cereals Child Childhood Clinical Cohort Studies Collaborations Contracts Data Data Collection Data Quality Development Diabetes Mellitus Diabetic Ketoacidosis Diagnosis Diet Records Dietary Factors Disease Education Enrollment Enterovirus Environmental Exposure Environmental Monitoring Environmental Risk Factor Epidemiologic Studies Erythrocytes Etiology Europe Event Exhibits Exposure to Family Fatty Acids Feces Finland First Degree Relative Frequencies Funding General Population Genes Genetic Genetic Polymorphism Genomics Genotype Gluten Goals Hour Household Hypersensitivity Immunization Incidence Infant Infection Infectious Agent Insulin Insulin-Dependent Diabetes Mellitus Intake Islets of Langerhans Joints Laboratories Lead Life Liquid substance Milk Molecular Mimicry Monitor Neonatal Screening Newborn Infant Nitrates Numbers Omega-3 Fatty Acids Outcome Study Participant Pathogenesis Patients Performance Plasma Plasma Cells Population Pre-Eclampsia Pregnancy Protocols documentation Psychological Stress Psychosocial Factor Publishing Questionnaires Rate Research Design Research Personnel Risk Rotavirus Sampling Scientist Screening procedure Serum Severities Specimen Standards of Weights and Measures Stress Structure Study Subject Testing Time Toxin United States Virus Vitamin D Vitamin E Work Zinc alpha Tocopherol base day design dietary constituent drinking water follow-up gamma-Tocopherol gene environment interaction genetic analysis improved infancy insight islet lissamine rhodamine B nitrate novel pet animal prevent programs prospective time use

项目摘要

DESCRIPTION (provided by applicant): This limited competition renewal application is for the Turku/Finland Clinical Center of The Environmental Determinants of Diabates in the Young (TEDDY) study. The primary objective of this multi-center, multi- national epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of islet autoimmunity and type 1 diabates mellitus (T1D). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression, or which provide protection from the development of T1D will also be identified. TEDDY is an observational cohort study in which newborns who are less than 4.5 months of age and have high risk HLA genotypes and come from the general population, or carry HLA risk alleles and are first-degree relatives of patients affected with T1D will be enrolled. Six Clinical Centers in the United States and Europe will screen 361,588 newborns of which it is anticipated that 17,804 will be eligible for enrollment, with just over 7,800 followed. Recruitment started in September 2004 and will continue until December 31, 2009. Participants will be followed to the age of 15 years. Identification of such etiologically important factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1D.

描述（由申请人提供）：这项有限的竞争更新申请是在年轻（泰迪）研究中为糖尿病环境决定因素的Turku/芬兰临床中心。这项多中心多个国家流行病学研究的主要目标是鉴定传染性药物，饮食因素或其他与胰岛自身免疫风险增加和1型糖尿病（T1D）相关的环境暴露。影响特定表型表现的因素，例如发病年龄或进展率，或提供免受T1D发展的保护的因素。泰迪（Teddy）是一项观察性队列研究，其中年龄小于4.5个月的新生儿具有高风险HLA基因型，来自普通人群，或携带HLA风险等位基因，并且是受T1D患者的一级亲戚。美国和欧洲的六个临床中心将筛选361,588个新生儿，预计将有17,804个有资格参加入学，其后仅7,800多个。招聘始于2004年9月，将持续到2009年12月31日。参与者将遵循15岁。鉴定此类病因重要的因素将使人们对疾病发病机理有更好的了解，并导致预防，延迟或反向T1D的新策略。