Stanford Career Development in Vascular Medicine

斯坦福血管医学职业发展

• 批准号: 8324232
• 负责人: RONALD L DALMAN
• 金额: $ 52.16万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8324232
• 关键词: Address; Arteries; Bioinformatics; Biometry; Blood Vessels; Breeding; Cardiovascular system; Caring; Cellular biology; Cessation of life; Clinical; Clinical Research; Clinical Trials Design; Computer Simulation; Data Base Management; Development; Discipline; Disease; Elements; Endocrinology; Engineering; Epidemiology; Exposure to; Faculty; Funding; Genetic; Genomics; Grant; Hematology; Hospitalization; Immunology; Institutes; Institutional Review Boards; Internist; Knowledge; Lymphatic Diseases; Manuscripts; Mechanics; Medicine; Mentors; Molecular; Molecular Biology; Morbidity - disease rate; Nephrology; Pharmacology; Physics; Physiology; Preparation; Proteomics; Public Health; Pulmonology; Regulatory Affairs; Research; Research Personnel; Research Project Grants; Technology; Tissues; Training; Training Programs; United States; Universities; Update; Vascular Diseases; Veins; Venous; Work; Writing; abstracting; career development; clinical practice; clinically relevant; cohort; design; experience; medical specialties; mortality; multidisciplinary; next generation; programs; responsible research conduct; stem cell biology

DESCRIPTION (provided by applicant): Vascular disease is the leading cause of morbidity and mortality in the United States. There is a public health need for increased transfer of knowledge between the various disciplines that constitute this research field, and accelerated application of the basic information to clinical practice. The Stanford program addresses with a multidisciplinary program and faculty performing scientific and clinical work related directly to Vascular Medicine including cardiovascular and pulmonary medicine, endocrinology, hematology, nephrology, immunology, epidemiology and clinical trials design, cell and molecular biology, developmental and stem cell biology, tissue and mechanical engineering, physics and computational modeling, genetics/genomics,proteomics, physiology and molecular pharmacology. This proposal is designed to address the educational and clinical needs in the emerging specialty of Vascular Medicine. The program will produce clinician investigators with a deep fund of knowledge regarding vascular medicine, and a high level of proficiency in clinical research. This new breed of investigators will apply cutting edge technology to clinically relevant questions in vascular medicine, and they will be able to train the next generation of vascular internists. Our Specific aims are to: 1) Develop, institute and annually evaluate a one year core clinical training program that confers competency in the management of arterial, venous and lymphatic diseases and associated disorders; 2) Formulate, initiate and annually update a didactic training program in clinical research emphasizing clinical trial design, biostatistics and bioinformatics, genomics and proteomics, regulatory affairs, and responsible conduct of research; 3) Provide a clinical research experience guided by an experienced Mentor, facilitated by a cohort of collaborative Co-mentors, and focused on a clinical research project. Other elements include exposure to trial design, interaction with and direct participation on the Institutional Review Board, database management and analysis, manuscript preparation, and grant writing. Lay description: Diseases of the arteries and veins cause most of the hospitalizations and deaths in the United States. Stanford University proposes a comprehensive educational program that will train a new breed of doctors that can recognize and treat these diseases, develop new therapies, and train young doctors in the care of people with vessel disease. (End of Abstract).

描述（由申请人提供）： 血管疾病是美国发病率和死亡率的主要原因。公共卫生需要增加构成该研究领域的各个学科之间知识的转移，并加速了基本信息在临床实践中的应用。斯坦福大学计划通过多学科计划和教师进行科学和临床工作，直接与血管医学有关遗传学/基因组学，蛋白质组学，生理学和分子药理学。该建议旨在满足血管医学新兴专业的教育和临床需求。该计划将生产有关血管医学知识的深厚知识基金，并在临床研究中熟练的水平。这一新的研究人员将在血管医学中将尖端技术应用于临床相关问题，他们将能够培训下一代血管内科医生。 我们的具体目的是：1）开发，建立和每年评估一年的核心临床培训计划，该计划赋予了动脉，静脉和淋巴病及相关疾病的管理能力； 2）在临床研究方面制定，启动和每年更新一项教学培训计划，强调临床试验设计，生物统计学和生物信息学，基因组学和蛋白质组学，法规事务以及负责任的研究； 3）提供以经验丰富的导师为指导的临床研究经验，由一系列协作联合会员促进，并专注于临床研究项目。其他要素包括接触试验设计，与机构审查委员会，数据库管理和分析，手稿准备以及赠款写作的互动并直接参与。铺面描述：动脉和静脉的疾病导致美国大多数住院和死亡。斯坦福大学提出了一项全面的教育计划，该计划将培训一系列新的医生，这些医生可以识别和治疗这些疾病，发展新的疗法，并培训年轻医生，以照顾患有血管疾病的人。 （摘要结束）。

项目成果

Assessing endothelial vasodilator function with the Endo-PAT 2000.

• DOI: 10.3791/2167
• 发表时间: 2010-10-15
• 期刊: Journal of visualized experiments : JoVE
• 作者: Axtell, Andrea L;Gomari, Fatemeh A;Cooke, John P
• 通讯作者: Cooke, John P

Clinical trials of adult stem cell therapy for peripheral artery disease.

成体干细胞治疗外周动脉疾病的临床试验。

• DOI: 10.14797/mdcj-9-4-201
• 发表时间: 2013
• 期刊: Methodist DeBakey cardiovascular journal
• 作者: Botham,CrystalM;Bennett,WilliamL;Cooke,JohnP
• 通讯作者: Cooke,JohnP

Spatial patterning of endothelium modulates cell morphology, adhesiveness and transcriptional signature.

• DOI: 10.1016/j.biomaterials.2013.01.017
• 发表时间: 2013-04
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Huang, Ngan F.;Lai, Edwina S.;Ribeiro, Alexandre J. S.;Pan, Stephen;Pruitt, Beth L.;Fuller, Gerald G.;Cooke, John P.
• 通讯作者: Cooke, John P.

A critical role for thioredoxin-interacting protein in diabetes-related impairment of angiogenesis.

• DOI: 10.2337/db13-0417
• 发表时间: 2014-02
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Dunn LL;Simpson PJ;Prosser HC;Lecce L;Yuen GS;Buckle A;Sieveking DP;Vanags LZ;Lim PR;Chow RW;Lam YT;Clayton Z;Bao S;Davies MJ;Stadler N;Celermajer DS;Stocker R;Bursill CA;Cooke JP;Ng MK
• 通讯作者: Ng MK

Development of a dimethylarginine dimethylaminohydrolase (DDAH) assay for high-throughput chemical screening.

• DOI: 10.1177/1087057112441521
• 发表时间: 2012-06
• 期刊: Journal of biomolecular screening
• 作者: Ghebremariam YT;Erlanson DA;Yamada K;Cooke JP
• 通讯作者: Cooke JP