The 8th Annual Cerebral Cavernous Malformations (CCM) Scientific Meeting

第八届年度脑海绵状血管瘤 (CCM) 科学会议

• 批准号: 8458915
• 负责人: Amy Lee Akers
• 金额: $ 1.15万
• 依托单位: ANGIOMA ALLIANCE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458915
• 关键词: Accounting; Address; Advocacy; Affect; Autopsy; Award; Basic Science; Biochemical; Biological Markers; Biology; Blood Vessels; Brain; Brain Diseases; Brain Stem; Brain hemorrhage; CCM1 gene; Caring; Cavernous Malformation; Cellular biology; Cerebrum; Cessation of life; Charge; Clinical; Clinical Data; Clinical Sciences; Clinical Treatment; Clinical Trials; Collaborations; Commit; Communities; Coupled; Development; Disease; Educational workshop; Fees; Fostering; Funding; Funding Opportunities; Future; Genes; Genetic; Genotype; Government Agencies; Headache; Health Professional; Hearing; Hemangioma; Human; Individual; Industry; International; Investigational New Drug Application; Lesion; Magnetic Resonance Imaging; Mission; Mutation; Neuraxis; Neurologic; Neurology; Pathogenesis; Patient advocacy; Patients; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacology; Phenotype; Physicians; Prevalence; Procedures; Process; Proteomics; Radiology Specialty; Rare Diseases; Recurrence; Regulation; Research; Research Personnel; Scientist; Seizures; Series; Spinal Cord; Staging; Stroke; Symptoms; Tight Junctions; Time; Training; Translating; Travel; Vascular Diseases; Vision; advocacy organizations; base; brain surgery; clinical care; cohort; design; empowered; loved ones; meetings; millimeter; neurosurgery; next generation; peer; posters; programs; symposium; treatment trial

DESCRIPTION (provided by applicant): Cerebral cavernous malformations (CCM) is a vascular disease of the central nervous system characterized by the presence of vascular lesions in the brain and spinal cord. Clinical symptoms associated with CCM are variable and may include recurrent headaches, focal neurological deficits, seizures, hemorrhagic stroke and/or death. There is no pharmacological treatment available for CCM patients - conservative management by observation or brain surgery are the only current treatment options. Thus, there is a critical need to more fully elucidate the pathobiology and disease mechanisms associated with CCM so that preventative pharmacological treatments can be developed. Developing treatments and translating research findings to the human phenotype will require global collaboration from stakeholders in research, clinical care, advocacy, industry, and government agencies. Facilitating these advancements and collaborations is a priority of Angioma Alliance - the patient advocacy organization for those affected by CCM. The primary objective of this proposal is to host the 8th annual CCM Scientific Meeting. The annual Angioma Alliance CCM Scientific Meeting is the only venue for international researchers and clinicians to assemble and share their latest CCM research data and clinical findings. There are no other disease-based meetings, workshops or conferences dedicated to the topic of cerebral cavernous malformations. No other national or international meetings attract the same cohort of scientists from fields including genetics, vascular biology, pharmacology, neurology, radiology, neurosurgery, proteomics, and cell biology; all of whom are dedicated to fully elucidating the pathobiology of CCM and translating those findings to the human condition. The CCM Scientific Meeting focuses on the future for the patient community, both for seeking a cure and also by fostering the training and development of the next generation of CCM scientists and physicians. The field of CCM research continues to advance rapidly. In keeping with this pace, this proposal is designed to request partial funding to help support the continued expansion of the CCM Scientific Meeting program. We intend to host a scientific meeting with the following specific aims: 1. To gather a diverse group of clinical and basic science investigators focusing on CCM research and related fields. 2. To provide a training opportunity and showcase for young investigators. 3. To create an action plan for the design and implementation of clinical treatment trials. ! PUBLIC HEALTH RELEVANCE: Cerebral cavernous malformations (CCM) is a debilitating disease of the brain and spinal cord that can cause affected individuals to suffer recurrent headaches, hearing and vision problems, seizures and/or stroke. At this time there is no available drug treatment; the only option for most patients is to undergo brain surgery. The CCM Scientific Meeting is designed to gather the world's experts on this illness to discuss the latest n research advances and plan for future research collaborations and clinical drug trials.

描述（由申请人提供）：脑海绵状畸形（CCM）是中枢神经系统的血管疾病，其特征是大脑和脊髓中存在血管病变。与CCM相关的临床症状是可变的，可能包括复发性头痛，局灶性神经缺陷，癫痫发作，出血性中风和/或死亡。 CCM患者没有可用的药理治疗方法 - 通过观察或脑外科手术进行保守管理是唯一的治疗选择。因此，迫切需要更充分地阐明与CCM相关的病理生物学和疾病机制，以便可以开发预防药理治疗。开发治疗方法并将研究结果转化为人类表型将需要研究，临床护理，倡导，工业和政府机构的利益相关者的全球合作。促进这些进步和合作是血管瘤联盟的优先事项 - 血管瘤联盟是受CCM影响者的患者倡导组织。该提案的主要目的是举办第八届年度CCM科学会议。年度血管瘤联盟CCM科学会议是国际研究人员和临床医生组装和分享其最新CCM研究数据和临床发现的唯一场所。没有其他基于疾病的会议，研讨会或专门针对脑海绵状畸形主题的会议。没有其他国家或国际会议吸引来自遗传学，血管生物学，药理学，神经病学，放射学，神经外科，蛋白质组学和细胞生物学等领域的相同科学家。所有人都致力于充分阐明CCM的病理生物学，并将这些发现转化为人类状况。 CCM科学会议的重点是患者社区的未来，既是寻求治愈方法，又是通过培养下一代CCM科学家和医生的培训和发展。 CCM研究领域继续迅速发展。为了保持这种速度，该提案旨在要求部分资金，以帮助支持CCM科学会议计划的持续扩展。我们打算举办以下特定目的的科学会议：1。收集一组专注于CCM研究和相关领域的临床和基础科学研究者。 2。为年轻的调查人员提供培训机会和展示。 3。为设计和实施临床治疗制定行动计划 试验。呢 公共卫生相关性：脑海绵状畸形（CCM）是一种令人衰弱的大脑和脊髓疾病，可导致受影响的个体复发，听力和视力问题，癫痫发作和/或中风。目前没有可用的药物治疗；对于大多数患者来说，唯一的选择是接受脑外科手术。 CCM科学会议旨在收集有关这种疾病的世界专家，讨论最新的N研究进展，并计划未来的研究合作和临床药物试验。