FASEB SRC on Protease in Hemostasis and Vascular Biology

FASEB SRC 关于蛋白酶在止血和血管生物学中的作用

基本信息

批准号：
8128143
负责人：
JAY L DEGEN
金额：
$ 1万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-05-01 至 2012-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8128143
关键词：
Achievement Address American Animal Model Area Arizona Basic Science Biochemistry Biology Blood Cells Blood Vessels Cardiovascular Diseases Cellular biology Clinical Clinical Medicine Collaborations Commit Communities Coupled Coupling Development Discipline Disease Embryonic Development Engineering Environment Equilibrium Event Faculty Fostering Functional disorder Future Genetic Goals Hemostatic function Host Defense Image Immunology Individual Industry Inflammation Inflammatory International Life Medical Medical Technology Medicine Minority Molecular Genetics Morbidity - disease rate Myocardial Infarction Nature Neurobiology Participant Pathologic Processes Pathology Pathway interactions Peptide Hydrolases Pharmacology Physicians Physiological Processes Plasma Proteins Platelet Activation Play Postdoctoral Fellow Prevention Process Recombinants Recording of previous events Regulation Research Research Activity Research Personnel Role Schedule Scientist Series Signal Transduction Site Societies Stroke Structure Students Surface System Talents Technology Therapeutic Therapeutic Agents Thrombin Thrombosis Thrombus Transgenic Animals Translational Research Vascular Diseases Vascular Permeabilities Vascular System Virulence Western World Woman Work Wound Healing base cardiovascular disorder prevention catalyst demographics design disability human MADHIP protein in vivo inhibitor/antagonist innovation insight interest meetings mortality novel novel therapeutics programs receptor small molecule structural biology success symposium treatment strategy unpublished works

项目摘要

DESCRIPTION (provided by applicant): Partial support is requested for the "Proteases in Hemostasis and Vascular Biology" conference to be held under the auspices of the Summer Research Conference program of the Federation of American Societies for Experimental Biology (FASEB). This meeting will be the 10th in a series that has been held biennially since 1992 and is scheduled to be held at the FASEB summer conference site in Carefree, Arizona on June 12-17, 2011. The focus of the meeting has evolved from one originally devoted to structure-function studies of thrombin into a broader arena of proteases in hemostasis and vascular biology. Interest in this area has been exceptionally strong and research activity is accelerating based on new insights on the role of proteases and their receptors, substrates and inhibitors in hemostasis, vascular cell signaling, barrier function, embryonic development, bacterial virulence/host defense, and inflammatory diseases, including cardiovascular disease and neuroinflammatory disease. This unique conference has established itself in the field of proteases and vascular biology and enjoys an international reputation for consistently emphasizing unpublished, cutting-edge basic and translational research by investigators with diverse expertise and broad demographics. The meeting has routinely drawn together a powerful mix of premiere established investigators, outstanding young investigators and gifted trainees for intimate, balanced, highly-interactive and synergistic scientific exchanges. Some of the most spectacular recent achievements in the area of proteases in vascular biology were first unveiled at previous conferences and the collegial environment has routinely fostered important new research initiatives. The roster of invited speakers and discussion leaders who have already agreed to participate is impressive and include top investigators in the field. These attendees will enhance the stimulating nature of the environment for all attendees and especially junior investigators and trainees. As in past conferences, a priority of the organizers will be to promote program participation of women and minorities and facilitate attendance by junior faculty, students, postdoctoral fellows and individuals with physical disabilities. The program currently includes a keynote address and 9 sessions devoted to (1) platelet activation/regulation of thrombus formation, (2) biochemistry and cell biology of proteases and their receptors and inhibitors, (3) novel serine proteases and mechanisms coupling proteases to disease, (4) fXII- and fXI-dependent events in vivo, (5) protease signaling and vascular biology, (6) integrated systems controlling vascular permeability, (7) proteases in inflammation and host defense, (8) protease engineering and therapeutics, and (9) protease targets in neurobiology.

描述（由申请人提供）：请求部分支持“止血和血管生物学中的蛋白酶”会议，该会议将在美国实验生物学会联合会（FASEB）夏季研究会议计划的赞助下举行。此次会议将是自 1992 年以来每两年举行一次的系列会议中的第十次，计划于 2011 年 6 月 12 日至 17 日在亚利桑那州 Carefree 的 FASEB 夏季会议地点举行。会议的重点已从最初的一个致力于凝血酶的结构功能研究，进入止血和血管生物学中更广泛的蛋白酶领域。人们对这一领域的兴趣异常浓厚，基于对蛋白酶及其受体、底物和抑制剂在止血、血管细胞信号传导、屏障功能、胚胎发育、细菌毒力/宿主防御和炎症中的作用的新见解，研究活动正在加速发展疾病，包括心血管疾病和神经炎症疾病。这次独特的会议在蛋白酶和血管生物学领域确立了自己的地位，并因始终强调具有不同专业知识和广泛人口统计数据的研究人员进行的未发表的前沿基础和转化研究而享有国际声誉。会议定期汇聚了顶尖研究者、杰出年轻研究者和天才学员的强大组合，进行亲密、平衡、高度互动和协同的科学交流。血管生物学蛋白酶领域的一些最引人注目的最新成就首次在之前的会议上公布，大学环境通常会促进重要的新研究举措。已同意参加的受邀演讲者和讨论领袖名单令人印象深刻，其中包括该领域的顶尖研究人员。这些与会者将增强所有与会者，特别是初级研究人员和受训人员的环境的刺激性。与以往的会议一样，组织者的首要任务是促进妇女和少数族裔的项目参与，并促进初级教师、学生、博士后研究员和身体残疾者的参加。该计划目前包括一个主题演讲和 9 个会议，致力于 (1) 血小板激活/血栓形成的调节，(2) 蛋白酶及其受体和抑制剂的生物化学和细胞生物学，(3) 新型丝氨酸蛋白酶以及蛋白酶与疾病的耦合机制，(4) 体内 fXII 和 fXI 依赖性事件，(5) 蛋白酶信号传导和血管生物学，(6) 控制血管通透性的集成系统，(7) 炎症和宿主中的蛋白酶防御，（8）蛋白酶工程和治疗，以及（9）神经生物学中的蛋白酶靶标。