Cell Death Pathways: Beyond Apoptosis

细胞死亡途径：超越细胞凋亡

• 批准号: 8257455
• 负责人: James Wavell Aiken
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257455
• 关键词: Address; Adult; Alberta province; Apoptosis; Area; Autophagocytosis; Bioenergetics; Bioinformatics; Biology; Biomedical Research; Canada; Caspase; Cell Death; Cell Death Induction; Cells; Cellular biology; Cessation of life; Clinical; Complex; Defect; Degenerative Disorder; Disabled Persons; Disease; Environment; Event; Family; Functional disorder; Genetic; Intervention; Joints; Knowledge; Malignant Neoplasms; Mind; Mitochondria; Modality; Molecular; Molecular Biology; Mutate; Nature; Nerve Degeneration; Neurosciences; Normal tissue morphology; Outcome; Pathogenesis; Pathway interactions; Peptide Hydrolases; Personal Satisfaction; Phenotype; Play; Postdoctoral Fellow; Quality Control; Regulation; Relative (related person); Request for Proposals; Research; Research Personnel; Role; Science; Signal Pathway; Signal Transduction; Students; Systems Biology; Therapeutic; Work; aged; anticancer research; base; bench to bedside; cohort; meetings; mitochondrial dysfunction; neoplastic cell; prevent; response; symposium; tool

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Cell Death Pathways: Beyond Apoptosis, organized by Serge Przedborski and Richard J. Youle, which will be held in Banff, Alberta, Canada from March 19 - 24, 2012. Mounting evidence indicates that cell death in diseases results from complex interactions between molecular mechanisms taking place within the degenerating cells (cell-autonomous) and outside the degenerating cells (non-cell autonomous). At the cross road of these diverse signaling pathways are found the mitochondria which, through proper mitochondrial dynamics and regulated mitochondrial elimination by autophagy (i.e., mitophagy), play a crucial role in maintaining the well-being of the cells. This meeting will focus on the general mechanisms of cell death including the Bcl-2 family and caspase proteases, the role of mitochondrial dynamics and mitophagy, the usefulness of bioinformatics to unravel death-pathways, the contribution of non-cell autonomous mechanisms to cell death, and on therapeutic strategies to protect against cell death. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Mitochondrial Dynamics and Function, which will share a keynote address and two plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: In the healthy human adult, more than one million cells die each second to avoid the accumulation of superfluous, ectopic, damaged, aged or mutated cells. Hence, cell death and its regulation are of central importance for biomedical research at many levels: for understanding normal tissue biology and the pathogenesis of numerous diseases, for pharmacological interventions that prevent unwarranted cell death, as well as for the therapeutic destruction of tumor cells. The Keystone Symposia meeting on Cell Death Pathways: Beyond Apoptosis will bring together investigators from many distinct fields in order to facilitate new ideas regarding the means by which cell death can be manipulated for therapeutic purposes.

描述（由申请人提供）：本提案请求支持由 Serge Przedborski 和 Richard J. Youle 组织的题为“细胞死亡途径：超越细胞凋亡”的 Keystone 研讨会，该会议将于 3 月 19 日至 24 日在加拿大艾伯塔省班夫举行， 2012.越来越多的证据表明，疾病中的细胞死亡是由退化细胞（细胞自主）内部和退化细胞外部发生的分子机制之间复杂的相互作用造成的（非细胞自主）。在这些不同信号通路的交叉点上发现了线粒体，它通过适当的线粒体动力学和自噬（即线粒体自噬）调节线粒体消除，在维持细胞的健康方面发挥着至关重要的作用。本次会议将重点讨论细胞死亡的一般机制，包括 Bcl-2 家族和 caspase 蛋白酶、线粒体动力学和线粒体自噬的作用、生物信息学在揭示死亡途径方面的用途、非细胞自主机制对细胞死亡的贡献，以及防止细胞死亡的治疗策略。同期举行的线粒体动力学和功能会议将大大增加跨学科互动的机会，该会议将与本次会议共享主题演讲和两次全体会议。 公共健康相关性：在健康的成年人中，每秒有超过一百万个细胞死亡，以避免多余、异位、受损、老化或突变细胞的积累。因此，细胞死亡及其调节对于许多层面的生物医学研究至关重要：对于了解正常组织生物学和许多疾病的发病机制，对于防止不必要的细胞死亡的药物干预，以及对于肿瘤细胞的治疗性破坏。关于细胞死亡途径：超越细胞凋亡的 Keystone 研讨会将汇集来自许多不同领域的研究人员，以促进关于如何操纵细胞死亡以达到治疗目的的新想法。