The Role of the Direct and Indirect Striatal Pathways in Movement and Learning

直接和间接纹状体通路在运动和学习中的作用

• 批准号: 8121333
• 负责人: Alexxai V Kravitz
• 金额: $ 4.84万
• 依托单位: J. DAVID GLADSTONE INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8121333
• 关键词: Abbreviations; Address; Basal Ganglia; Basal Ganglia Diseases; Brain; Chronic; Complex; Corpus striatum structure; Data; Disease; Disinhibition; Drug Addiction; Fiber; Functional disorder; Globus Pallidus; Huntington Disease; Individual; Learning; Lesion; Link; Locomotion; Maintenance; Modeling; Motor output; Movement; Mus; Neurons; Outcome; Output; Parkinson Disease; Pathway interactions; Population; Relative (related person); Research; Research Personnel; Rewards; Role; Stimulus; Structure; Structure of subthalamic nucleus; Substantia nigra structure; Synapses; System; Techniques; Thalamic structure; awake; classical conditioning; in vivo; insight; motor control; neuronal cell body; novel; novel strategies; open field behavior; relating to nervous system; research study; response; synaptic inhibition; tool

DESCRIPTION (provided by applicant): Many diseases, including Parkinson's disease, Huntington's disease, and drug addiction, have been linked to dysfunction in a brain system called the basal ganglia. Despite decades of research on this system, there are no long-term treatments or cures for these disorders. This proposal aims to use novel techniques to investigate the basal ganglia, and thereby identify novel strategies and insights for treating diseases of the basal ganglia. PUBLIC HEALTH RELEVANCE: Many diseases, including Parkinson's disease, Huntington's disease, and drug addiction, have been linked to dysfunction in a brain system called the basal ganglia. Despite decades of research on this system, there are no long-term treatments or cures for these disorders. This proposal aims to use novel techniques to investigate the basal ganglia, and thereby identify novel strategies and insights for treating diseases of the basal ganglia.

描述（由申请人提供）：许多疾病，包括帕金森氏病，亨廷顿氏病和吸毒成瘾，都与称为基底神经节的大脑系统中的功能障碍有关。尽管对该系统进行了数十年的研究，但对于这些疾病仍未进行长期治疗或治疗方法。该建议旨在使用新颖的技术研究基底神经节，从而确定治疗基底神经节疾病的新型策略和见解。 公共卫生相关性：许多疾病，包括帕金森氏病，亨廷顿氏病和吸毒成瘾，都与称为基底神经节的脑系统中的功能障碍有关。尽管对该系统进行了数十年的研究，但对于这些疾病仍未进行长期治疗或治疗方法。该建议旨在使用新颖的技术研究基底神经节，从而确定治疗基底神经节疾病的新型策略和见解。