Regional & Racial Differences in Hemostasis & Risk of Stroke & Heart Disease

区域性

• 批准号: 8238403
• 负责人: Neil Adrian Zakai
• 金额: $ 14.1万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8238403
• 关键词: ADAMTS; Accounting; Address; Advisory Committees; Anticoagulants; Behavior; Behavioral; Biochemical; Biological; Biological Markers; Biometry; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Classification; Clinical; Coagulation Process; Cohort Studies; Collaborations; Coronary heart disease; Country; Cox Models; Data; Disintegrins; Ensure; Epidemiology; Factor Analysis; Factor VIII; Faculty; Fibrin fragment D; Future; Health; Health behavior; Heart Diseases; Hematology; Hemostatic Agents; Hemostatic function; Incidence; Individual; Ischemic Stroke; Laboratories; Life; Measures; Mediating; Mediation; Mentors; Metalloproteases; Modeling; Neurology; Outcome; Participant; Pathway interactions; Persons; Plasma; Population; Principal Component Analysis; Protein C; Psychosocial Factor; Public Health Schools; Reasons for Geographic And Racial Differences in Stroke; Relative (related person); Research; Research Personnel; Research Training; Risk; Risk Assessment; Risk Factors; Role; Sampling; Socioeconomic Status; Stroke; System; Teleconferences; Training Programs; Translational Research; United States; Universities; Vascular Diseases; Vermont; base; biobank; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular risk factor; career; cohort; design; epidemiologic data; experience; geographic difference; heart disease risk; high risk; lifestyle factors; meetings; member; mortality; novel; psychosocial; public health relevance; racial difference; receptor; regional difference; socioeconomics; von Willebrand Factor

DESCRIPTION (provided by applicant): We propose a 5-year research and training program for Dr. Neil A. Zakai (a junior faculty member at the University of Vermont) to develop an independent career in vascular epidemiology by investigating the impact hemostatic biomarker levels have on regional and racial differences in stroke and coronary heart disease (CHD) in the 30,228 black and white individuals in the REasons for Geographic and Racial Differences in Stroke study (REGARDS). Dr. Mary Cushman, an internationally recognized investigator in cardiovascular epidemiology, will serve as the principle mentor for this project. Though the period of this study, Dr. Cushman will support the educational and research aspects of this project. The advisory committee was selected from experts in epidemiology, neurology, and hematology to provide the best opportunities for networking and future collaborations. Dr. Zakai will meet with the advisory committee both in person and through teleconferences on a monthly basis. To achieve a future independent research career for Dr. Zakai, we propose specific coursework in epidemiology and biostatistics at the University of Vermont and the Johns Hopkins Bloomberg School of Public Health. The project will be a case-cohort study focusing on the impact of multiple hemostatic biomarkers (both individually and in groups) on the regional and racial differences in stroke and CHD incidence in the United States. The specific aims will 1) create the nested case-cohort study within REGARDS, 2) use multivariable modeling and factor analysis to elucidate mechanisms for stroke and CHD and 3) integrate hemostatic biomarkers and traditional CVD risk factors into a model for stroke and CHD risk that can account for racial and/or regional differences in CVD. The Laboratory for Clinical and Biochemical Research at the University of Vermont serves as an ideal setting to conduct this research by bringing together the laboratory aspects and the epidemiological expertise to ensure a rich translational research experience. PUBLIC HEALTH RELEVANCE: There are regional and racial differences in coronary heart disease and stroke not explained by conventional cardiovascular risk factors. We hypothesize that regional and racial differences in hemostasis underlie some of these disparities.

描述（由申请人提供）：我们为尼尔·A·扎凯（Neil A. Zakai）博士（佛蒙特大学的初级教职员工成员）提出了一项为期5年的研究和培训计划，以研究止血生物标志物对止血生物标志物的影响，从而在30.30、22的竞技场（chd and consoprication and Geogricial and Racogriate in 30,22222222）的区域差异来发展血管流行病学的独立职业。 （问候）。 国际认可的心血管流行病学研究员玛丽·库什曼（Mary Cushman）将作为该项目的主要导师。尽管这项研究的期限，库什曼博士将支持该项目的教育和研究方面。咨询委员会是从流行病学，神经病学和血液学专家中选出的，以提供网络和未来合作的最佳机会。 Zakai博士将每月与咨询委员会会面。为了实现Zakai博士的未来独立研究职业，我们在佛蒙特大学和约翰·霍普金斯大学彭博公共卫生学院提出了特定的流行病学和生物统计学课程。 该项目将是一项案例研究研究，重点介绍了多种止血生物标志物（单独和组中）对美国中风和种族差异的影响。具体目的是1）在以下方面创建嵌套的病例研究研究，2）使用多变量的建模和因子分析来阐明中风和冠心动物的机制，以及3）将止血生物标志物和传统CVD风险因素整合到中风和CHD风险的模型中，这些风险可以考虑CVD中的种族和/或区域差异。 佛蒙特大学的临床和生物化学研究实验室是通过将实验室方面和流行病学专业知识汇总在一起，以确保丰富的翻译研究经验，是进行这项研究的理想环境。 公共卫生相关性：常规心血管危险因素没有解释冠心病的区域和种族差异。我们假设止血的区域和种族差异是其中一些差异的基础。