Core B: Study Design and Molecular Epidemiology Core

核心 B：研究设计和分子流行病学核心

基本信息

批准号：
10230991
负责人：
Neil Adrian Zakai
金额：
$ 31.04万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10230991
关键词：
Address Adult American Heart Association Americas Area Atherosclerosis Award Back Biochemistry Biological Biological Assay Biological Markers Biology Biometry Biostatistical Methods Cardiovascular Diseases Cardiovascular system Cause of Death Centers of Research Excellence Cessation of life Chronic Disease Clinical Clinical Research Clinical Trials Cognitive Cohort Studies Collaborations Collection Communities Consultations Coronary heart disease Dementia Discipline Disease Educational workshop Elements Ensure Epidemiologic Methods Epidemiologist Epidemiology Evolution Experimental Designs Faculty Fee-for-Service Plans Funding Future Genomics Grant Health Heart Diseases Hematologist Home Impaired cognition Individual Jackson Heart Study Journals Knowledge Laboratories Leadership Mediator of activation protein Mentors Methods Molecular Molecular Epidemiology National Heart, Lung, and Blood Institute Participant Performance Philosophy Population Population Research Program Development Proteomics Public Health Publications Quality Control Reasons for Geographic And Racial Differences in Stroke Reporting Research Research Design Research Personnel Resources Risk Factors Role Sampling Scientist Service delivery model Services South Asian Statistical Data Interpretation Stroke Testing Time Trans-Omics for Precision Medicine Translating Universities Vermont Work assay development biobank brain health cardiovascular health cardiovascular risk factor career complex data cost estimate design disability experience flipped classroom genome sequencing innovation investigator training laboratory experience metabolomics modifiable behavior modifiable risk multi-ethnic multidisciplinary neurovascular novel operation skills success whole genome

项目摘要

PROJECT SUMMARY Cardiovascular disease, stroke and cognitive impairment / dementia are leading causes of death and disability, and they arise from several common antecedents. The proposed Vermont Center for Cardiovascular and Brain Health (VCCBH) COBRE at the University of Vermont will address these diseases employing collaborative research. This will be conducted by diverse scientists from multiple disciplines working together to understand the pathobiology and molecular epidemiology of these diseases in order to meet the public health challenges presented by them. The Study Design and Molecular Epidemiology Core (CORE B) of the COBRE will support the evolution of the Center's Project Directors to independent status. It will leverage three decades of experience of the Laboratory for Clinical and Biochemistry Research at the University of Vermont, a leading molecular epidemiology laboratory and home to a biorepository containing ~4.7 million samples from >100,000 research participants from many observational cohort studies and clinical trials. The core will equip the multi- disciplinary Project Directors with the skills they need to conduct their research applying innovative study designs and statistical analyses, and to translate their results from bench or clinical research settings to the population research setting and back, regardless of their prior experience in epidemiology. Our philosophy is that a Core should not only provide service but should train an investigator to be skilled in all of the key elements that the Core provides. Thus, the Core will provide Project Directors with initial and ongoing formal input on their study design and statistical approaches (Aim 1); advise Project Directors on all aspects of biosample procurement, storage, and analysis, including optimizing and troubleshooting assay performance (Aim 2); and support their transition to independence by connecting them with the resources of national studies that will allow them to translate their research to clinical settings (Aim 3). The Core co-directors, Dr. Neil Zakai and Dr. Peter Durda, along with Core biostatisticians, will guide the Project Directors. Dr. Zakai is a hematologist and chronic disease epidemiologist with expertise in many types of study designs, biostatistical approaches to complex data, and laboratory operations, while Dr. Durda has vast experience in molecular laboratory methods and epidemiology. Together, Drs. Zakai and Durda will provide individualized assistance to project directors and innovative workshops utilizing a flipped classroom approach. Services will also be offered to Pilot Grant award recipients who will be supported by institutionally committed funds, to other investigators in the Center's Pipeline development program of potential future Project Directors, and to the UVM research community using a fee-for-service model. Over time the Core will become sustainable, serving the needs of the cardiovascular and neurovascular research community at the University of Vermont.

项目概要心血管疾病、中风和认知障碍/痴呆是死亡和残疾的主要原因，它们源于几个共同的背景。拟议的佛蒙特州心血管和大脑中心佛蒙特大学健康 (VCCBH) COBRE 将通过合作解决这些疾病研究。这将由来自多个学科的不同科学家共同进行，以了解这些疾病的病理学和分子流行病学，以应对公共卫生挑战他们提出的。 COBRE 的研究设计和分子流行病学核心 (CORE B) 将支持中心项目主任向独立地位发展。它将利用三十年的经验佛蒙特大学临床和生物化学研究实验室的经验，领先的分子流行病学实验室和生物样本库的所在地，其中包含来自超过 100,000 个样本的约 470 万个样本来自许多观察性队列研究和临床试验的研究参与者。该核心将配备多学科项目主任具有应用创新研究进行研究所需的技能设计和统计分析，并将其结果从实验室或临床研究环境转化为人口研究背景和背景，无论他们以前在流行病学方面的经验如何。我们的理念是核心不仅应该提供服务，还应该培训调查员熟练掌握所有关键知识核心提供的元素。因此，核心将为项目总监提供初始和持续的正式对其研究设计和统计方法的投入（目标 1）；就项目的各个方面向项目总监提供建议生物样本采购、储存和分析，包括分析性能的优化和故障排除（目标 2）；并通过将他们与国家资源联系起来支持他们向独立过渡研究将使他们能够将研究成果转化为临床环境（目标 3）。核心联合董事，博士。 Neil Zakai 和 Peter Durda 博士以及核心生物统计学家将指导项目总监。扎凯博士是血液学家和慢性病流行病学家，在多种类型的研究设计、生物统计学方面拥有专业知识处理复杂数据和实验室操作的方法，而 Durda 博士在分子领域拥有丰富的经验实验室方法和流行病学。在一起，博士。 Zakai 和 Durda 将提供个性化帮助项目主管和创新研讨会采用翻转课堂方法。还将提供服务致将获得机构承诺资金支持的试点补助金获奖者、其他研究人员参与该中心潜在未来项目总监的管道开发计划以及 UVM 研究社区采用按服务付费的模式。随着时间的推移，核心将变得可持续，满足人们的需求佛蒙特大学心血管和神经血管研究社区。