Core B: Study Design and Molecular Epidemiology Core

核心 B：研究设计和分子流行病学核心

• 批准号: 10230991
• 负责人: Neil Adrian Zakai
• 金额: $ 31.04万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10230991
• 关键词: Address; Adult; American Heart Association; Americas; Area; Atherosclerosis; Award; Back; Biochemistry; Biological; Biological Assay; Biological Markers; Biology; Biometry; Biostatistical Methods; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Centers of Research Excellence; Cessation of life; Chronic Disease; Clinical; Clinical Research; Clinical Trials; Cognitive; Cohort Studies; Collaborations; Collection; Communities; Consultations; Coronary heart disease; Dementia; Discipline; Disease; Educational workshop; Elements; Ensure; Epidemiologic Methods; Epidemiologist; Epidemiology; Evolution; Experimental Designs; Faculty; Fee-for-Service Plans; Funding; Future; Genomics; Grant; Health; Heart Diseases; Hematologist; Home; Impaired cognition; Individual; Jackson Heart Study; Journals; Knowledge; Laboratories; Leadership; Mediator of activation protein; Mentors; Methods; Molecular; Molecular Epidemiology; National Heart, Lung, and Blood Institute; Participant; Performance; Philosophy; Population; Population Research; Program Development; Proteomics; Public Health; Publications; Quality Control; Reasons for Geographic And Racial Differences in Stroke; Reporting; Research; Research Design; Research Personnel; Resources; Risk Factors; Role; Sampling; Scientist; Service delivery model; Services; South Asian; Statistical Data Interpretation; Stroke; Testing; Time; Trans-Omics for Precision Medicine; Translating; Universities; Vermont; Work; assay development; biobank; brain health; cardiovascular health; cardiovascular risk factor; career; complex data; cost estimate; design; disability; experience; flipped classroom; genome sequencing; innovation; investigator training; laboratory experience; metabolomics; modifiable behavior; modifiable risk; multi-ethnic; multidisciplinary; neurovascular; novel; operation; skills; success; whole genome

PROJECT SUMMARY Cardiovascular disease, stroke and cognitive impairment / dementia are leading causes of death and disability, and they arise from several common antecedents. The proposed Vermont Center for Cardiovascular and Brain Health (VCCBH) COBRE at the University of Vermont will address these diseases employing collaborative research. This will be conducted by diverse scientists from multiple disciplines working together to understand the pathobiology and molecular epidemiology of these diseases in order to meet the public health challenges presented by them. The Study Design and Molecular Epidemiology Core (CORE B) of the COBRE will support the evolution of the Center's Project Directors to independent status. It will leverage three decades of experience of the Laboratory for Clinical and Biochemistry Research at the University of Vermont, a leading molecular epidemiology laboratory and home to a biorepository containing ~4.7 million samples from >100,000 research participants from many observational cohort studies and clinical trials. The core will equip the multi- disciplinary Project Directors with the skills they need to conduct their research applying innovative study designs and statistical analyses, and to translate their results from bench or clinical research settings to the population research setting and back, regardless of their prior experience in epidemiology. Our philosophy is that a Core should not only provide service but should train an investigator to be skilled in all of the key elements that the Core provides. Thus, the Core will provide Project Directors with initial and ongoing formal input on their study design and statistical approaches (Aim 1); advise Project Directors on all aspects of biosample procurement, storage, and analysis, including optimizing and troubleshooting assay performance (Aim 2); and support their transition to independence by connecting them with the resources of national studies that will allow them to translate their research to clinical settings (Aim 3). The Core co-directors, Dr. Neil Zakai and Dr. Peter Durda, along with Core biostatisticians, will guide the Project Directors. Dr. Zakai is a hematologist and chronic disease epidemiologist with expertise in many types of study designs, biostatistical approaches to complex data, and laboratory operations, while Dr. Durda has vast experience in molecular laboratory methods and epidemiology. Together, Drs. Zakai and Durda will provide individualized assistance to project directors and innovative workshops utilizing a flipped classroom approach. Services will also be offered to Pilot Grant award recipients who will be supported by institutionally committed funds, to other investigators in the Center's Pipeline development program of potential future Project Directors, and to the UVM research community using a fee-for-service model. Over time the Core will become sustainable, serving the needs of the cardiovascular and neurovascular research community at the University of Vermont.

项目摘要 心血管疾病，中风和认知障碍 /痴呆是死亡和残疾的主要原因， 它们源于几个常见的先决条件。拟议的佛蒙特州心血管和大脑中心 佛蒙特大学的卫生（VCCBH）COBRE将解决这些疾病，采用合作 研究。这将由来自多个学科的多元化科学家共同努力，以了解 这些疾病的病理生物学和分子流行病学，以应对公共卫生挑战 由他们提出。 COBRE的研究设计和分子流行病学核心（核心B）将 支持该中心项目董事到独立身份的演变。它将利用三十年 佛蒙特大学临床和生物化学研究实验室的经验，佛蒙特大学是领先的 分子流行病学实验室和含有约100,000个样本的生物座的所在地 来自许多观察队列研究和临床试验的研究参与者。核心将装备多 纪律项目导演具有他们需要进行创新研究的研究所需的技能 设计和统计分析，并将其结果从基准或临床研究环境转化为 人口研究环境和背部，无论其在流行病学方面的先前经验如何。我们的哲学是 核心不仅应该提供服务，而且应该培训调查员以熟练所有关键 核心提供的元素。因此，核心将为项目总监提供最初和持续的正式 他们的研究设计和统计方法的输入（AIM 1）；就所有方面的各个方面提供建议 生物样品采购，存储和分析，包括优化和故障排除测定性能 （目标2）;并通过将他们与国家资源联系起来来支持他们向独立的过渡 将使他们将研究转化为临床环境的研究（AIM 3）。核心联合导演博士 尼尔·扎凯（Neil Zakai）和彼得·杜尔达（Peter Durda）博士以及核心生物统计学家将指导项目主管。 Zakai博士是一个 血液学家和慢性疾病流行病学家在许多类型的研究设计中具有专业知识，生物统计学 复杂数据和实验室操作的方法，而Durda博士在分子方面具有丰富的经验 实验室方法和流行病学。在一起，博士。 Zakai和Durda将为 利用翻转课堂方法的项目主管和创新研讨会。服务也将提供 向将由机构承诺的资金提供支持的试点赠款奖授予的获奖者 在中心的潜在未来项目董事的管道开发计划中，以及UVM研究 使用收费服务模型的社区。随着时间的流逝，核心将变得可持续，以满足 佛蒙特大学的心血管和神经血管研究社区。