Neural correlates of PTSD in veterans with blast-related traumatic brain injury

爆炸相关创伤性脑损伤退伍军人 PTSD 的神经相关性

• 批准号: 8259692
• 负责人: ALAN N SIMMONS
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8259692
• 关键词: Affect; Affective; Age; Amygdaloid structure; Anisotropy; Anxiety; Area; Arousal; Behavioral; Biological Markers; Blast Cell; Brain; Brain Injuries; Brain imaging; Classification; Clinic; Clinical; Cognitive; Corpus Callosum; Diagnostic; Diagnostic Imaging; Diffuse; Diffusion Magnetic Resonance Imaging; Disease; Dorsal; Emotional; Emotions; Freedom; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Glucose; Grant; Healthcare; Imaging technology; Individual; Injury; Insula of Reil; Intervention; Intervention Studies; Investigation; Lateral; Lead; Left; Life; Ligands; Limbic System; Location; Maps; Measurement; Medical; Memory; Methods; Modeling; Neurobiology; Outcome Measure; Physiological; Population; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Public Health; Recording of previous events; Relative (related person); Reporting; Risk; Sampling; Severities; Sex Education; Shapes; Soldier; Stimulus; Stress; Structure; Symptoms; Synaptic Transmission; System; Techniques; Therapeutic Intervention; Trauma; Traumatic Brain Injury; Triage; Veterans; War; Work; base; brain metabolism; clinical care; combat; disability; disorder risk; executive function; experience; hemodynamics; high risk; imaging modality; improved; neural model; neuropsychiatry; operation; relating to nervous system; resilience; response; stressor; uptake; white matter

DESCRIPTION (provided by applicant): Soldiers in the war zone are at high risk for potentially significant of emotional and cognitive repercussions resulting from blast impacts in combat zones. Although mild blast-related TBI (mTBI) and Posttraumatic Stress Disorder (PTSD) result in significant disability and are of major public health importance, little is known about the mechanism of these injuries. Our application attempts to integrate three brain imaging methods (DTI, fMRI, and PET) to better understand the neural systems involved in mTBI and PTSD. Diffusion Tensor Imaging (DTI) has shown great initial promise as a technique for understanding the underlying neural structure of both TBI and PTSD. Functional magnetic resonance imaging (fMRI) allows for measurement of the hemodynamic brain response to specific stimuli, such as trauma related content that and has shown efficacy in PTSD. Positron Emission Tomography (PET) allows for the measurement of specific glucose ligands to map neural transmission, this technique has been very productive in determining the neuro biomarkers in PTSD and mTBI. Our aim is to determine neural biomarkers that can differentiate mTBI, and mTBI with PTSD. In the short run, we may be able to develop more exact model for the neural effects of these disorders in our veteran population. In the long run, we hope to determine neural biomarkers that can provide a objective and neural representation of disease course for therapeutic intervention studies. PUBLIC HEALTH RELEVANCE: Project Narrative: In the proposed grant we aim to combine three imaging modalities with psychological and neuropsychological assessments to investigate the relationship between PTSD and mTBI. Veterans who are returning from combat deployment who experience a significant combat related trauma can experience one or both of these conditions. Determination of appropriate treatment and of treatment success depends on appropriate diagnosis which is difficult as there conditions share numerous clinical and behavioral manifestations. Advancements in our understanding can lead directly to better quality of care. Definition and verification of neuropsychiatric biomarkers of these conditions can advance our capacity to measure outcome of clinic interventions (such as in the PI's current CDMRP grant). In this grant, we aim to provide empirical evidence to improve diagnostic approaches and determination of intervention quality so as to have a direct impact on positively shaping healthcare for our veteran's who are suffering combat related injury and stress.

描述（由申请人提供）： 战区中的士兵面临着可能引起战斗区域爆炸撞击引起的情绪和认知影响的高风险。尽管轻度爆炸相关的TBI（MTBI）和创伤后应激障碍（PTSD）导致了严重的残疾，并且对公共健康的重要性至关重要，但对这些伤害的机制知之甚少。我们的应用程序试图整合三种大脑成像方法（DTI，fMRI和PET），以更好地了解MTBI和PTSD涉及的神经系统。扩散张量成像（DTI）已显示出巨大的初始诺言，作为理解TBI和PTSD的潜在神经结构的一种技术。功能磁共振成像（fMRI）允许测量对特定刺激的血液动力学响应，例如与创伤相关的含量，并在PTSD中显示出功效。正电子发射断层扫描（PET）允许测量特定的葡萄糖配体来绘制神经传递，该技术在确定PTSD和MTBI中的神经生物标志物方面非常有效。我们的目的是确定可以与PTSD区分MTBI的神经生物标志物。在短期内，我们也许能够为这些疾病在退伍军人人群中的神经影响开发更精确的模型。从长远来看，我们希望确定可以为治疗干预研究提供客观和神经表示的神经生物标志物。 公共卫生相关性： 项目叙述：在拟议的赠款中，我们旨在将三种成像方式与心理和神经心理学评估相结合，以研究PTSD和MTBI之间的关系。从战斗部署中返回的退伍军人经历了与战斗相关的创伤，可以遇到其中一种或两种情况。确定适当的治疗和治疗成功取决于适当的诊断，这很困难，因为那里有许多临床和行为表现。我们理解的进步可以直接导致更好的护理质量。对这些疾病的神经精神生物标志物的定义和验证可以提高我们衡量临床干预措施结果的能力（例如PI当前的CDMRP赠款）。在这笔赠款中，我们旨在提供经验证据，以改善诊断方法和确定干预质量，以直接影响为我们的退伍军人的医疗保健，他们正在遭受与战斗有关的伤害和压力。

项目成果

Neural correlates of malingering in mild traumatic brain injury: A positron emission tomography study.

轻度创伤性脑损伤中装病的神经相关性：正电子发射断层扫描研究。

• DOI: 10.1016/j.pscychresns.2015.06.007
• 发表时间: 2015
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Spadoni,AndreaD;Kosheleva,Elena;Buchsbaum,MonteS;Simmons,AlanN
• 通讯作者: Simmons,AlanN

Neural measures associated with configural threat acquisition.

与配置威胁获取相关的神经测量。

• DOI: 10.1016/j.nlm.2018.03.012
• 发表时间: 2018
• 期刊: Neurobiology of learning and memory
• 影响因子: 2.7
• 作者: Stout,DanielM;Glenn,DanielE;Acheson,DeanT;Spadoni,AndreaD;Risbrough,VictoriaB;Simmons,AlanN
• 通讯作者: Simmons,AlanN