Patient Oriented Research and Mentorship Program in Obesity

以患者为中心的肥胖研究和指导计划

• 批准号: 8045701
• 负责人: CHRISTINA C WEE
• 金额: $ 19.1万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8045701
• 关键词: Address; Adult; Adverse effects; Affect; African American; Age; Attenuated; Award; Bariatrics; Biological Markers; Blood specimen; Body Weight decreased; Body mass index; Cause of Death; Censuses; Characteristics; Clinical; Cohort Studies; Communities; Data; Data Set; Databases; Decision Making; Diagnosis; Disadvantaged; Education; Epidemiologic Studies; Expenditure; Faculty; Funding; Genetic; Genetic Markers; Goals; HIV; Health; Health Expenditures; Health Policy; Health Services; Healthcare; Heterogeneity; Hispanic Americans; Homicide; Income; Intervention; Investigation; Laboratories; Link; Medical; Medicare; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Minority; Modeling; Modification; National Health Interview Survey; Neighborhoods; Obesity; Operative Surgical Procedures; Other Genetics; Outcome; Patients; Perioperative; Play; Policies; Population; Postdoctoral Fellow; Prevalence; Primary Health Care; Procedures; Public Health; Race; Recommendation; Relative (related person); Research; Research Personnel; Research Training; Resources; Risk; Risk-Taking; Role; Sampling; Series; Smoking; Source; Staging; Structure; Surgeon; Techniques; Time; Training; Treatment outcome; Variant; Weight; Work; age group; aged; attenuation; bariatric surgery; base; cardiovascular risk factor; career development; clinical decision-making; clinical epidemiology; cohort; expectation; experience; mortality; next generation; novel; obesity treatment; patient oriented research; patient population; programs; racial difference; social; socioeconomics; willingness; young adult

DESCRIPTION (provided by applicant): This application is for a Midcareer Investigator Award (K24) to support Patient-Oriented Research and Mentoring in obesity. This award will support 50% of Dr. Wee's effort for each of 5 years. Dr. Wee will devote 30% effort to mentoring postdoctoral fellows, junior faculty, and other research trainees in obesity investigation, and another 20% to expand the scope of her current research program. Dr. Wee will provide her trainees with structured mentoring and research training and assist them in initiating their own investigations and mentor them through the stages of career development. Trainees will be able to leverage the resources of Dr. Wee's current research program which includes 2 active R01 projects. The first project analyzes 3 large nationally- representative datasets to understand the interplay of race and obesity on 4 outcomes: 1) mortality; 2) novel cardiovascular risk factors; 3) delays in the diagnosis and control of traditional cardiovascular risk factors; and 4) healthcare expenditures. The objective of this project is to clarify whether previously observed attenuations in obesity's adverse impact on mortality and health expenditures in Africans Americans (AAs) relative to Whites can be explained by racial differences on several fronts: competing health risks; an attenuated relationship between obesity and novel cardiovascular risk factors in AAs; and disparities in diagnosis and treatment. In new research, Dr. Wee proposes a novel application of competing risk models to estimate the degree to which competing (nonobesity-related) mortality risks explain observed racial differences in BMI-mortality relationships derived from more traditional analytic methods. Dr. Wee's second R01 project is a multicenter cohort study to understand how patients value weight loss and make decisions about weight treatment particularly weight loss surgery (WLS). The goals of this project are to 1) describe the perspectives of patients in terms of their utility (value) and expectations for weight loss and their willingness to take risks to achieve weight loss; 2) identify predictors that are associated with better WLS outcomes, and 3) understand the factors and barriers patients in primary care encounter in deciding whether or not to undergo WLS and other weight treatments. In new research, Dr. Wee proposes to create a blood sample data repository to explore the role genetic and other biomarkers play in patient decision-making and in predicting outcomes of WLS. This K24 award will allow the creation of a mentorship program in obesity patient-oriented research and allow Dr. Wee to expand her research portfolio in new directions that will guide clinical decision-making and public health policy related to obesity. PUBLIC HEALTH RELEVANCE: This award will allow Dr. Wee to devote 50% of her time training the next generation of researchers and expanding her current research in the field of obesity. Research from her program will help us better understand how obesity affects different populations and how patients make decisions about whether to undergo weight loss treatment. This information will help guide efforts to and policy changes that might reduce current disparities in weight loss treatment.

描述（由申请人提供）：此申请是为中级研究员奖（K24）提供的，以支持以患者为导向的研究和肥胖指导。该奖项将支持Wee博士在5年中的50％的努力。 Wee博士将花30％的努力来指导博士后研究员，初级教职员工和其他研究肥胖研究的研究人员，并另外20％的努力扩大了她当前的研究计划的范围。 Wee博士将为受训者提供结构化的指导和研究培训，并帮助他们启动自己的调查，并通过职业发展阶段进行指导。学员将能够利用Wee博士当前的研究计划的资源，其中包括2个活跃的R01项目。第一个项目分析了3个大型国家代表性数据集，以了解4个结果的种族与肥胖的相互作用：1）死亡率； 2）新颖的心血管危险因素； 3）延迟诊断和控制传统心血管危险因素； 4）医疗支出。该项目的目的是澄清以前观察到的肥胖症对非洲人（AAS）相对于白人的死亡率和健康支出的不利影响是否可以通过几种方面的种族差异来解释：竞争健康风险； AAS中肥胖与新型心血管危险因素之间的衰减关系；诊断和治疗方面的差异。在新的研究中，Wee博士提出了一种竞争风险模型的新型应用，以估计竞争（非肥胖相关）死亡率风险的程度解释了观察到的种族差异，该种族差异是由更传统的分析方法得出的。 Wee博士的第二个R01项目是一项多中心队列研究，旨在了解患者如何重视体重减轻并做出有关体重治疗的决策，尤其是减肥手术（WLS）。该项目的目标是1）描述患者的效用（价值）以及对体重减轻的期望以及承担体重减轻的风险的意愿； 2）确定与更好的WLS结果相关的预测因素，以及3）在决定是否接受WLS和其他体重治疗时，了解初级保健中遇到的因素和障碍患者。在新的研究中，Wee博士建议创建一个血样数据存储库，以探讨遗传和其他生物标志物在患者决策中的作用以及预测WLS的结果。该K24奖将允许在肥胖症患者的研究中创建指导计划，并允许Wee博士在新的方向上扩展其研究组合，以指导与肥胖有关的临床决策和公共卫生政策。 公共卫生相关性：该奖项将使Wee博士能够将50％的时间用于培训下一代研究人员，并扩大她在肥胖领域的目前研究。她计划的研究将有助于我们更好地了解肥胖如何影响不同人群以及患者如何做出有关是否接受减肥治疗的决定。这些信息将有助于指导努力和政策变化，以减少减肥治疗中当前差异。