International Conference on Dental and Craniofacial Stem Cells

国际牙科和颅面干细胞会议

基本信息

批准号：
8007279
负责人：
JEREMY J MAO
金额：
$ 1.5万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-17 至 2011-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In the past two decades, cells with properties of stem/progenitor cells have been isolated and identified from dental, oral and craniofacial (DOC) tissues. For the first time in the history of dental and craniofacial research, it is possible to manipulate the very cells that differentiate into many of the tissues in the face and oral cavity. The practice of dentistry and craniofacial reconstruction rests on tissues that derived from DOC stem/progenitor cells, and will be transformed, over time, by the development of translational and therapeutic approaches based on the understanding of DOC stem/progenitor cells. However, our existing knowledge of DOC stem/progenitor cells is fragmentary at best. DOC stem cells originate from neural crest-derived mesenchyme, and possess unique characteristics that distinguish them from commonly studied bone-marrow derived mesenchymal cells. Upon their discovery about 9 years ago, the volume of scientific literature on DOC stem/progenitor cells has grown exponentially. Alarmingly, DOC stem/progenitor cells are being infused in preclinical models and patients with only fragmented knowledge of their behavior. Accordingly, we propose the first international conference dedicated to dental, oral and craniofacial stem/progenitor cells, not only to discuss and disseminate current knowledge on the biology of DOC stem/progenitor cells, but also their putative applications in the regeneration of tissues of the oral cavity and the face. The overall goal of this proposal is to design and plan the first International Conference on Dental and Craniofacial Stem Cells (ICDCSC) in a forum that promotes the dissemination of knowledge and identification of future directions in relation to DOC stem/progenitor cell research and translation. Broad consensus among conference participants will form the basis for establishing scientific guidelines, including rigorous molecular and functional assays for self renewal, differentiation and translation of DOC stem/progenitor cells. This conference is being planned to take place in October, 2010 in New York City, which has direct flights to/from numerous U.S. and international cities, and in a setting that is conducive for multi-disciplinary discussion of the science and therapeutic potential of DOC stem/progenitor cells. The conference will be widely attended by scientists, clinicians, government officials, and industry representatives in dental, biotechnology and pharmaceutical industries. We have received overwhelmingly robust response from not only scientists, but also government officials and dental, biotechnology and pharmaceutical industry. The outcome of this conference will be published in a high impact stem cell or regenerative medicine journal and serve as working and evolving guidelines for the dynamic field of the biology and translation of DOC stem/progenitor cells. PUBLIC HEALTH RELEVANCE: In the past decade and beyond, postnatal cells with properties of stem/progenitor cells have been isolated and identified from dental, oral and craniofacial (DOC) tissues. For the first time in the history of dental and craniofacial research, we have the ability to manipulate the very cells that differentiate into many tissue or organ in the face and oral cavity. It is projected that the practice of dentistry and craniofacial reconstruction will be transformed, over time, by the development of translational and therapeutic approaches that rely on the understanding of DOC stem cells. The overall goal of this proposal is to design and plan the first International Conference on Dental and Craniofacial Stem Cells (ICDCSC) in a forum that promotes the dissemination of knowledge and identification of future directions in relation to DOC stem/progenitor cell research and translation. The conference will be widely attended by scientists, clinicians, government officials, and industry representatives in dental, biotechnology and pharmaceutical industries. The outcome of this conference will be published in a high impact stem cell or regenerative medicine journal and serve as working and evolving guidelines for the dynamic field of the biology and translation of DOC stem/progenitor cells.

描述（由申请人提供）：在过去的二十年中，已经分离出具有茎/祖细胞特性的细胞从牙齿，口服和颅面（DOC）组织中鉴定出来。在牙齿和颅面研究史上，第一次可以操纵分化为面部和口腔中许多组织的细胞。牙科和颅面重建的实践取决于源自DOC茎/祖细胞细胞的组织，并且会根据对DOC STEM/祖细胞的理解来开发转化和治疗方法，随着时间的流逝而转化。但是，我们对DOC茎/祖细胞的现有知识充其量是零碎的。 DOC干细胞起源于神经rest衍生的间充质，并具有独特的特征，可将其与常见研究的骨髓衍生的间充质细胞区分开。大约9年前发现，关于DOC STEM/祖细胞的科学文献的数量已成倍增长。令人震惊的是，DOC STEM/祖细胞被注入临床前模型中，并且仅了解其行为知识的患者。因此，我们提出了第一次致力于牙科，口腔和颅面茎/祖细胞的国际会议，不仅是讨论和传播有关DOC STEM/祖细胞生物学的当前知识，而且还用于在口腔腔和面部组织的再生中的推定应用。该提案的总体目标是在一个论坛中设计和计划第一次关于牙科和颅面干细胞（ICDCSC）国际会议，该论坛促进了与DOC STEM/祖细胞研究和翻译有关的知识传播和未来方向的传播。会议参与者之间的广泛共识将构成建立科学指南的基础，包括用于自我更新，DOC STEM/祖细胞的自我更新，分化和翻译的严格分子和功能分析。该会议计划于2010年10月在纽约市举行，该会议直接往返美国和国际城市，并有利于对DOC STEM/祖细胞的科学和治疗潜力进行多学科讨论的环境。该会议将在牙科，生物技术和制药行业的科学家，临床医生，政府官员和行业代表中广泛参加。我们不仅得到了科学家的压倒性反应，而且还得到了政府官员和牙科，生物技术和制药行业的反应。这次会议的结果将在高影响干细胞或再生医学杂志上发表，并作为DOC STEM/祖细胞的生物学动态领域的工作和发展指南。公共卫生相关性：在过去的十年及以后，已从牙科，口腔和颅面（DOC）组织中分离出具有茎/祖细胞特性的产后细胞。在牙齿和颅面研究史上，我们第一次有能力操纵分化为面部和口腔中许多组织或器官的细胞。预计，随着时间的流逝，牙科和颅面重建的实践将通过依赖于对DOC干细胞的理解的转化和治疗方法的发展来改变。该提案的总体目标是在一个论坛中设计和计划第一次关于牙科和颅面干细胞（ICDCSC）国际会议，该论坛促进了与DOC STEM/祖细胞研究和翻译有关的知识传播和未来方向的传播。该会议将在牙科，生物技术和制药行业的科学家，临床医生，政府官员和行业代表中广泛参加。这次会议的结果将在高影响干细胞或再生医学杂志上发表，并作为DOC STEM/祖细胞的生物学动态领域的工作和发展指南。