Vitamin D in Obstructive Lung Diseases

维生素 D 在阻塞性肺疾病中的作用

基本信息

批准号：
7472463
负责人：
AUGUSTO A LITONJUA
金额：
$ 26.25万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-20 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7472463
关键词：
Adrenal Cortex Hormones Adult Affect African American Age American Area Asthma Birth Blood Boston Breathing Budesonide Caucasians Caucasoid Race Cause of Death Cell physiology Cells Child Childhood Childhood Asthma Chronic Disease Chronic Obstructive Airway Disease Clinical Trials Cohort Studies Costa Rica Costa Rican Data Data Set Development Dietary intake Disease Exploratory/Developmental Grant Exposure to Food Frequencies General Population Genetic Grant HIV Health Care Costs Healthcare Hispanics Hormones Hospitalization Immune Immune System and Related Disorders Immune system Inflammatory Bowel Diseases Intake Laboratories Lead Letters Lung diseases Maintenance Malignant Neoplasms Measures Mediating Morbidity - disease rate Multiple Sclerosis NIH Program Announcements Nedocromil North America Nutrient Obstructive Lung Diseases Outcome Participant Personal Satisfaction Phenotype Placebos Play Population Predisposition Pregnancy Prevalence Public Health Pulmonary Function Test/Forced Expiratory Volume 1 Questionnaires Randomized Recruitment Activity Recurrence Research Respiratory physiology Rheumatoid Arthritis Risk Risk Factors Role Sampling Serum Severities Specimen Sunlight Supplementation Therapeutic Time United States Upper arm Virus Diseases Visit Vitamin D Vitamin D Deficiency Vitamin D3 Receptor Wheezing base cohort cost human subject improved indexing men methacholine mortality mycobacterial novel prevent programs response

项目摘要

DESCRIPTION (provided by applicant): Asthma and chronic obstructive lung disease (COPD) are some of the leading causes of morbidity in children and adults, respectively. Asthma is the most common chronic disease of childhood in the developed world, incurs significant healthcare costs, and the prevalence of asthma has continued to increase. It has been estimated that as many as 16 million Americans have COPD and it is now the fourth most common cause of death in the United States. Among the top 5 causes of death, COPD is the only major disease that is continuing to increase in both prevalence and mortality. There is preliminary data that vitamin D intake can affect the development of wheezing phenotypes in young children and that serum vitamin D levels are associated with lung function. Vitamin D receptors are present in immune cells and vitamin D plays a role in the development and function of the cells of the immune system, and it is postulated that vitamin D may play a role in asthma and COPD via these effects on the immune system. However, there have been no studies that have shown decreased vitamin D levels in subjects with asthma or COPD. Thus, before pursuing more expensive and definitive studies such as clinical trials of vitamin D supplementation, more convincing evidence is needed for the association between vitamin D and these lung diseases. This project proposes to measure vitamin D levels from stored serum samples in three cohorts - two asthma cohorts (the Childhood Asthma Management Program cohort and the Genetics of Asthma in Costa Rica cohort) and an adult general population cohort (the Normative Aging Study cohort). We will determine whether there are any differences in vitamin D levels between Caucasian, African- American, and Hispanic asthmatics, and whether vitamin D is associated with more severe asthma in the asthma cohorts. We will also determine whether vitamin D is associated with lung function decline and development of COPD in the adult cohort. If we are able to demonstrate an association between vitamin D and these outcomes, this will pave the way for more definitive studies of the role of vitamin D in obstructive lung diseases, asthma and COPD. Showing a relationship between vitamin D levels in serum and obstructive lung diseases will have great public health significance and will add to the evidence that recommended vitamin D intakes need to be increased. Additionally, supplementation with vitamin D can be implemented in cost-effective population-based programs to prevent the development of, and treat these disorders.

描述（由申请人提供）：哮喘和慢性阻塞性肺病（COPD）分别是儿童和成人发病的主要原因。哮喘是发达国家儿童最常见的慢性疾病，会产生巨大的医疗费用，而且哮喘的患病率持续增加。据估计，有多达 1600 万美国人患有慢性阻塞性肺病，目前它是美国第四大常见死因。在前 5 位死因中，慢性阻塞性肺病是唯一一种患病率和死亡率均持续上升的主要疾病。初步数据表明，维生素 D 摄入量可影响幼儿喘息表型的发展，并且血清维生素 D 水平与肺功能相关。维生素 D 受体存在于免疫细胞中，维生素 D 在免疫系统细胞的发育和功能中发挥作用，并且推测维生素 D 可能通过对免疫系统的这些影响在哮喘和慢性阻塞性肺病中发挥作用。然而，尚无研究表明哮喘或慢性阻塞性肺病患者的维生素 D 水平降低。因此，在进行更昂贵和更明确的研究（例如补充维生素 D 的临床试验）之前，需要更令人信服的证据来证明维生素 D 与这些肺部疾病之间的关联。该项目建议测量三个队列中储存的血清样本中的维生素 D 水平 - 两个哮喘队列（儿童哮喘管理计划队列和哥斯达黎加哮喘遗传学队列）和一个成人普通人群队列（规范老龄化研究队列）。我们将确定白种人、非裔美国人和西班牙裔哮喘患者之间的维生素 D 水平是否存在差异，以及维生素 D 是否与哮喘队列中更严重的哮喘有关。我们还将确定维生素 D 是否与成人队列中肺功能下降和 COPD 的发展相关。如果我们能够证明维生素 D 与这些结果之间的关联，这将为维生素 D 在阻塞性肺病、哮喘和慢性阻塞性肺病中的作用进行更明确的研究铺平道路。显示血清中维生素 D 水平与阻塞性肺疾病之间的关系将具有重大的公共卫生意义，并将为需要增加推荐维生素 D 摄入量提供证据。此外，补充维生素 D 可以在具有成本效益的基于人群的计划中实施，以预防和治疗这些疾病。