Incidence and etiology of pneumonia in children

儿童肺炎的发病率和病因

• 批准号: 8243295
• 负责人: JONATHAN A MCCULLERS
• 金额: $ 82.06万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8243295
• 关键词: Incidence; etiology; pneumonia; children

DESCRIPTION (provided by applicant): Pneumonia and influenza, taken together, are a leading cause of hospitalization and death in the United States. Although it has been appreciated for more than 2 centuries that influenza predisposes the host to secondary bacterial infections, the incidence and etiology of influenza-associated pneumonia has never been comprehensively studied. Several epidemiologic trends are fueling a desire to gain better insight into interactions between viruses and bacteria in the pathogenesis of pneumonia. In studies employing comprehensive diagnostic methods, the incidence of co-infections in CAP appears to be at least 40%. For these reasons, the time is right to undertake prospective study of the role of co-infections in pneumonia in children using comprehensive and sensitive diagnostic assays. We propose to conduct a clinical study of the incidence and etiology of pneumonia in hospitalized children at Le Bonheur Children's Hospital in Memphis, Tennessee in association with St. Jude Children's Research Hospital. We will use this opportunity to answer some interesting and important scientific questions about co-infections in this population. The underlying hypothesis for our Proposed Studies is that co-infections result in poorer outcomes than single infections. We will test this hypothesis by prospectively collecting sociodemographic, microbiological, clinical, and genomics data to determine associations with clinical outcomes.

描述（由申请人提供）：总的来说，肺炎和流感是美国住院和死亡的主要原因。 尽管在2个多世纪中，流感易受宿主的次要细菌感染，但人们对造影症相关的肺炎的发病率和病因从未进行过全面研究。几种流行病学趋势正在推动渴望更好地了解肺炎发病机理中病毒与细菌之间相互作用的愿望。在采用全面诊断方法的研究中，CAP中的共同感染的发生率似乎至少为40％。由于这些原因，使用全面和敏感的诊断测定法对肺炎共同感染在儿童中的作用进行前瞻性研究。我们建议在田纳西州孟菲斯的Le Bonheur儿童医院与St. Jude儿童研究医院联合，对住院儿童的肺炎病因和病因进行临床研究。我们将利用这个机会回答有关该人群共同感染的一些有趣而重要的科学问题。我们提出的研究的基本假设是，共同感染的结果比单一感染较差。我们将通过前瞻性收集社会人口统计学，微生物学，临床和基因组学数据来检验这一假设，以确定与临床结果的关联。