PATHOGENESIS OF ORAL RHESUS LYMPHOCRYPTOVIRUS INFECTION

口腔恒河猴淋巴细胞病毒感染的发病机制

• 批准号: 8172865
• 负责人: Frederick C. Wang
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172865
• 关键词: Acute; CD8B1 gene; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Epstein-Barr Virus Infections; Funding; Goals; Grant; Hairy Leukoplakia; Human; Immune response; Immunocompetent; Immunocompromised Host; Infection; Institution; Lymphocryptovirus; Lytic; Macaca mulatta; Oral; Pathogenesis; Proteins; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Viral; immunosuppressed; lytic replication; novel therapeutic intervention; simian human immunodeficiency virus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this study is understand the role of lytic viral replication during acute EBV infection of immunocompetent and immunosuppressed hosts. The proposal includes the following specific aims: Specific Aim #1 - What is the role of viral replication in primary rhLCV infection after oral inoculation of immunocompetent rhesus macaques? Specific Aim #2 - What is the role of viral replication in primary rhLCV infection after oral inoculation of SHIV immunosuppressed rhesus macaques? Specific aim #3 - How early do CD8+ CTL specific for lytic proteins develop in acute rhLCV infection? These studies will elucidate the role of lytic viral replication and the immune response during acute infection that would otherwise be difficult, or impossible, to study in humans. A better understanding of the interplay between lytic EBV infection and the immune response to lytic EBV proteins will contribute to development of novel therapeutic approaches for control of EBV infection and diseases associated with lytic EBV replication, such as oral hairy leukoplakia.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的总体目标是了解免疫活性和免疫抑制宿主急性 EBV 感染期间裂解病毒复制的作用。 该提案包括以下具体目标： 具体目标#1 - 免疫活性恒河猴口服接种后，病毒复制在原发性 rhLCV 感染中的作用是什么？ 具体目标 #2 - 口服 SHIV 免疫抑制恒河猴后，病毒复制在原发性 rhLCV 感染中发挥什么作用？ 具体目标 #3 - 在急性 rhLCV 感染中，裂解蛋白特异性 CD8+ CTL 的发育时间有多早？ 这些研究将阐明急性感染期间裂解病毒复制和免疫反应的作用 否则将很难或不可能在人类身上进行研究。更好地理解裂解之间的相互作用 EBV 感染和对裂解性 EBV 蛋白的免疫反应将有助于开发新的治疗方法 控制 EBV 感染和与裂解性 EBV 复制相关的疾病（例如口腔毛病）的方法 白斑。