ALZHEIMER?S DISEASE RESEARCH CENTER

阿尔茨海默病研究中心

• 批准号: 8173146
• 负责人: Sanjay Asthana
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173146
• 关键词: Aging; Alzheimer disease prevention; Alzheimer' s Disease; Arts; Behavior; Biological Markers; Biometry; Biotechnology; Brain imaging; Caring; Clinic; Clinical; Clinical Data; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Dementia; Development; Diagnostic; Diagnostic tests; Disease; Early Diagnosis; Education; Elderly; Funding; Genome; Geriatrics; Gerontology; Grant; Individual; Institutes; Institution; Laboratories; Leadership; Low income; Minority; National Institute on Aging; Neurosciences; Neurosciences Research; Patients; Prevention therapy; Primates; Registries; Research; Research Infrastructure; Research Personnel; Resources; Rural Population; Source; Staging; Symptoms; Translational Research; United States National Institutes of Health; Veterans; Wisconsin; clinical care; data management; neuropathology; novel; novel diagnostics; pre-clinical; professor; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To identify novel diagnostic tests and potential therapies for the prevention of Alzheimer's disease at a stage when patients have no clinical symptoms (preclinical stage). Sanjay Asthana, professor of geriatrics and gerontology, and director of the Geriatric Research, Education and Clinical Center (GRECC), in May 2009 landed a five-year $6.9 million National Institutes on Aging grant to launch the Wisconsin Alzheimer's Disease Research Center (ADRC). This new center will build upon the strengths of UW-Madison's remarkable neuroscience research to provide state-of-the-art resources, infrastructure, and expertise in Alzheimer's disease (AD) and related illnesses. With the major focus on preclinical and early diagnosis and progression of AD, the center will expand the scientific objectives of the Wisconsin Registry for Alzheimer's Prevention and significantly enhance care of Wisconsin residents suffering from the devastations of AD. The ADRC will be comprised of six cores: Administrative, Clinical, Data Management and Biostatistics, Neuropathology and Biomarkers, Education and Transfer and the Minority Recruitment Satellite Program. The center will build upon the highly successful UW research program in AD and several recent convergent developments: These include a new focus of the UW leadership on AD, substantial institutional and state financial commitment to AD research, presence of several renowned programs in neuroscience on the UW campus, outstanding UW clinical programs, an extensive statewide network of dementia diagnostic clinics, access to minority, low-income and rural populations through the Minority Recruitment Satellite Program (MRSP), acknowledged status of several UW investigators in AD research, and close collaborations between numerous UW centers and institutes in aging and neuroscience research. The involved centers and institutes include the Wisconsin Alzheimer's Institute, Institute on Aging, UW Waisman Center, UW Waisman Laboratory for Brain Imaging and Behavior, NIH/CTSA-funded Institute for Clinical and Translational Research (ICTR), Wisconsin National Primate Research Center, Biotechnology Center, Genome Center, Clinical and Translational Research Core (formerly known as the UW GCRC), and Madison Veterans Affairs (VA) Geriatric Research, Education and Clinical Center (GRECC). Given the access to outstanding resources and expertise, the Wisconsin ADRC is well poised to make novel contributions to the field of AD research and provide outstanding clinical care to patients suffering from the devastations of the disease. The major focus of the Wisconsin ADRC is to identify novel diagnostic tests and potential therapies for the prevention of Alzheimer's disease at a stage when patients have no clinical symptoms (preclinical stage). Asthana's team anticipates that such therapies will help reduce the number of individuals suffering from Alzheimer's disease.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：在患者没有临床症状（临床前阶段）的阶段，确定预防阿尔茨海默氏病的新型诊断测试和潜在疗法。 2009年5月，老年医学和老年医学教授桑杰·阿斯塔纳（Sanjay Asthana），老年研究，教育和临床中心（GRECC）的主任，授予了五年$ 690万美元的全国老龄化授予授予的国家授予，以启动威斯康星州阿尔茨海默氏病研究中心（ADRC）。 这个新中心将基于UW-Madison杰出的神经科学研究的优势，以提供最先进的资源，基础设施和阿尔茨海默氏病（AD）和相关疾病的专业知识。由于主要关注AD的临床前和早期诊断和进展，该中心将扩大威斯康星州注册中心的科学目标，以预防阿尔茨海默氏症，并显着增强对威斯康星州遭受AD破坏的居民的护理。 ADRC将由六个核心组成：行政，临床，数据管理和生物统计学，神经病理学和生物标志物，教育与转移以及少数族裔招聘卫星计划。 The center will build upon the highly successful UW research program in AD and several recent convergent developments: These include a new focus of the UW leadership on AD, substantial institutional and state financial commitment to AD research, presence of several renowned programs in neuroscience on the UW campus, outstanding UW clinical programs, an extensive statewide network of dementia diagnostic clinics, access to minority, low-income and rural populations through the Minority Recruitment Satellite Program （MRSP），几位UW研究人员在广告研究中的状况，以及众多UW中心与衰老和神经科学研究机构之间的密切合作。 参与的中心和机构包括威斯康星州阿尔茨海默氏症研究所，衰老研究所，威斯康星大学瓦斯曼市中心，UW Waisman大脑成像和行为实验室，NIH/CTSA资助的临床与翻译研究所（ICTR），Wisconsin National Research Center，Biotechnological as Cornolotic Central and Translisy Central，Us and Transly Central core the Core and Transly Centor，US，ICTR，ICTR，UCTR，ICTR）麦迪逊退伍军人事务（VA）老年研究，教育与临床中心（GRECC）。鉴于获得了杰出的资源和专业知识，威斯康星州ADRC旨在为广告研究领域做出新的贡献，并为患有疾病破坏的患者提供出色的临床护理。 威斯康星州ADRC的主要重点是在患者没有临床症状（临床前阶段）的阶段确定预防阿尔茨海默氏病的新型诊断测试和潜在的疗法。 Asthana的团队预计，这种疗法将有助于减少患阿尔茨海默氏病的人数。