THE ANTI-ALPHA-4/BETA-7 MONOCLONAL ANTIBODY PROJECT

抗 ALPHA-4/BETA-7 单克隆抗体项目

• 批准号: 8172475
• 负责人: Aftab A. Ansari
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172475
• 关键词: Acute; Affect; Attention; CD4 Positive T Lymphocytes; Cells; Chemokine (C-C Motif) Receptor 5; Chronic; Computer Retrieval of Information on Scientific Projects Database; Crohn' s disease; Disease Progression; Ensure; Funding; Gastrointestinal tract structure; Grant; HIV; Immune response; Infection; Inflammatory; Institution; Integrins; Monoclonal Antibodies; Organ; Outcome; Research; Research Personnel; Resources; SIV; Series; Source; Syndrome; Testing; United States National Institutes of Health; Viral; Virus Replication; chemokine receptor; cytokine; novel therapeutics; trafficking

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of the earliest organ affected by HIV and SIV infection is the GI tract. Moreover, the bulk of viral replication occurs in this compartment leading to rapid and permanenet elimination of CD4+ T cells, in particular those co expresing the viral co-receptor CCR5. What is not clear to date is whether the continuous viral replication requires a constant influx of new CD4 targets or not, which would open a novel therapeutic vista by blockign traffic of potential target cells to the gut. Traffic to various organs appears to be dictated via a series of receptors, chemokines and cytokines, which in concert are able to ensure a regular replenishment of select lineages within a given compartment. Among the molecules dictating traffic to the gut the heterodimeric integrin ¿4¿7 has gained particular attention especially in the therapy of gut inflammatory syndromes such as IBD, UC and Crohn's Disease. The use of an ¿4¿7 blocking agent has thus far not been tested in the context of lentivurs infection, which is the purpose of this study. Thanks to the availability of a primatized monoclonal antibody specific to ¿4¿7we propose to block this traffic during acute and chronic SIV infection in efforts to determine the outcome of such blockade on virus replication/dissemination, viral immune responses and ultimately disease progression.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 受艾滋病毒和SIV感染影响的最早的器官之一是胃肠道。此外，大部分病毒复制发生在此室中，导致CD4+ T细胞的快速和永久性演化，尤其是那些表达病毒共受体CCR5的室。迄今为止尚不清楚的是，连续病毒复制是否需要新的CD4靶标的持续影响，这将通过阻止潜在靶细胞到肠道的阻止流量来打开一种新型的治疗性远景。各种器官的流量似乎是通过一系列接收器，趋化因子和细胞因子来决定的，这些因子和细胞因子能够确保定期复制给定室内精选谱系的人。在指示肠道流量的分子中，异二聚体整合素€4已引起了人们的特别关注，尤其是在肠道炎性综合症的治疗中，例如IBD，UC和Crohn病。到目前为止，尚未在蜂巢感染的背景下测试过€4的阻滞剂，这是本研究的目的。感谢您对特定于€4的原始单克隆抗体的可用性，以阻止在急性和慢性SIV感染期间阻止这种交通，以确定这种对病毒复制/传播，病毒免疫调查的封锁的结果，并最终疾病进展。