NOVEL PROTEIN-PROTEIN DOCKING TOOLS

新型蛋白质-蛋白质对接工具

• 批准号: 8169352
• 负责人: CHANDRAJIT L BAJAJ
• 金额: $ 3.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169352
• 关键词: Algorithms; Cell physiology; Complex; Computer Retrieval of Information on Scientific Projects Database; Docking; Environment; Funding; Grant; Institution; Ion Channel; Methods; Proteins; Regulation; Research; Research Personnel; Resources; Source; Speed; Transcriptional Regulation; United States National Institutes of Health; novel; protein protein interaction; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Protein-Protein interaction is critical in the formation of enzymatic complexes, transcriptional regulation, and ion channel regulations, and many essential cellular processes. However, current protein-protein interaction algorithms used in computational approaches are still limited in both accuracy and speed. We propose to develop novel protein-protein docking methods with an advanced user interface environment.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 蛋白质-蛋白质相互作用对于酶复合物的形成、转录调节、离子通道调节以及许多重要的细胞过程至关重要。然而，当前计算方法中使用的蛋白质-蛋白质相互作用算法在准确性和速度方面仍然受到限制。我们建议开发具有先进用户界面环境的新型蛋白质-蛋白质对接方法。