EXTRAHIPPOCAMPAL STRUCTURAL ABNORMALITIES IN MESIAL TEMPORAL LOBE EPILEPSY

内侧颞叶癫痫的海马外结构异常

• 批准号: 8171043
• 负责人: JACK J LIN
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171043
• 关键词: Accounting; Anatomy; Atlases; Clinical; Cognitive; Collaborations; Computational Technique; Computer Retrieval of Information on Scientific Projects Database; Deformity; Disease; Doctor of Philosophy; Freedom; Funding; Grant; Gray unit of radiation dose; Hippocampus (Brain); Individual; Institution; Maps; Operative Surgical Procedures; Outcome; Patients; Pattern; Phase; Postoperative Period; Research; Research Personnel; Resources; Sclerosis; Seizures; Source; Techniques; Temporal Lobe Epilepsy; United States National Institutes of Health; Variant; gray matter; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will use three-dimensional probabilistic mapping techniques to delineate extrahippocampal anatomical abnormalities in patients with mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS), and correlate them with surgical outcome and post-operative cognitive profile. The study is being done in collaboration with Paul Thompson, PhD. who has developed a new computational technique that takes into account normal variations in gyral pattern across subjects. Thus, in this probabilistic morphometric technique, abnormal gray matter distribution can be distinguished from and related to the gyral anatomy of the individual.In the first phase of this study, deviations in gray and white matter distribution of patients with MTLE and HS with good surgicaloutcome will be averaged together retrospectively to construct a disease specific atlas. In phase two, comparisons will be made prospectively between individual anatomical deviations in gray and white matter distribution and the disease specific atlas in order to delineate individual extrahippocampal structural abnormalities. Correlations will be made between individual structural abnormalities and post-surgical cognitive outcome and seizure freedom. We will define anatomical regions in which regionally specificdeficits correlate best with clinical and cognitive parameters.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将使用三维概率的映射技术来描述与海马硬化（HS）患有近米颞叶癫痫（MTLE）患者的公发外解剖异常（HS），并将其与外科手术结果和术后认知能力相关。该研究正在与Paul Thompson博士合作完成。谁开发了一种新的计算技术，该技术考虑了跨受试者的陀螺模式的正常变化。因此，在这种概率的形态计量技术中，可以从个人的陀螺解剖结构区分开并相关。在这项研究的第一阶段中，MTLE和HS患者的灰质和白质分布的偏差和白质分布良好，将其良好的SurgicalOutcome的患者进行回顾性平均，以构建特定于疾病的疾病。 在第二阶段，将对灰质和白质分布的个体解剖偏差与疾病特定地图集的单个解剖偏差进行前瞻性进行比较，以划定单个单个的乳腺外结构异常。 个人结构异常与手术后的认知结果与癫痫发作自由之间将建立相关性。我们将定义解剖区域，其中特定于区域的缺陷与临床和认知参数最有联系。