BRAIN DEVELOPMENT ON ADULTS WITH SCHIZOPHRENIA

成年精神分裂症患者的大脑发育

• 批准号: 8171064
• 负责人: GEORGE BARTZOKIS
• 金额: $ 0.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171064
• 关键词: Adult; Area; Autopsy; Brain; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Grant; Gray unit of radiation dose; Institution; Intervention; Magnetic Resonance Imaging; Myelin; Outcome; Patients; Research; Research Personnel; Resources; Scanning; Schizophrenia; Source; Speed; Temporal Lobe; Testing; United States National Institutes of Health; brain volume; cohort; gray matter; improved; myelination; novel; theories; transmission process; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Magnetic resonance imaging has shown that normal brain development continues into the mid-to-late 40's when maximal white matter volumes are reached in the frontal and temporal lobes. This confirms postmortem evidence suggesting that myelination of these brain areas continues into the 40's. Myelin is crucial for normal brain function because it increases the speed of axonal transmission. The increase in myelination is well regulated and occurs in concert with a decrease in gray matter volume resulting in a constant brain volume in adulthood. Schizophrenia is believed to be a disease caused in part by abnormal brain development. We observed that when examined crossectionally, brain development was dysregulated in adult schizophrenic subjects with an absence of normal myelination in adulthood. This project will examine gray and white matter volume changes in schizophrenia and normal adults prospectively by rescanning cohorts of subjects that were initially scanned 5 and 11 years ago. The project will more definitively test the theory that in schizophrenia, brain development is dysregulated in adulthood and will examine whether patients that have a poor outcome are particularly likely to suffer from this developmental problem in adulthood. If confirmed, the prevailing concept of a fixed and therefore unreparable brain developmental problem causing all schizophrenia will be surpassed. This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 磁共振成像表明，当额叶和颞叶达到最大白质体积时，正常的大脑发育一直持续到40秒。这证实了死后证据表明，这些大脑区域的髓鞘形成一直持续到40年代。髓磷脂对于正常的大脑功能至关重要，因为它会增加轴突传播的速度。髓鞘形成的增加受到了良好的调节，并随着灰质体积减少而导致成年期恒定的大脑体积。精神分裂症被认为是脑发育异常引起的一种疾病。我们观察到，在横断面检查时，成人精神分裂症受试者的大脑发育失调，成年后没有正常的髓鞘形成。该项目将通过撤销最初扫描5年前和11年前扫描的受试者的同类群体，研究精神分裂症和正常成年人的灰质和白质体积变化。该项目将更明确地检验以下理论：在精神分裂症中，大脑发育在成年期失调，并将检查结果较差的患者是否特别有可能在成年期遭受这种发育问题。如果得到证实，将超越固定且无法弥补的大脑发育问题的普遍概念，导致所有精神分裂症。这将改变我们如何治疗这种疾病的概念，改变其终生过程的可行性，并鼓励开发新型的药理干预措施以改善髓鞘髓鞘。