BRAIN DEVELOPMENT ON ADULTS WITH SCHIZOPHRENIA

成年精神分裂症患者的大脑发育

• 批准号: 7724362
• 负责人: GEORGE BARTZOKIS
• 金额: $ 1.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724362
• 关键词: Adult; Area; Autopsy; Brain; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Grant; Gray unit of radiation dose; Institution; Intervention; Magnetic Resonance Imaging; Myelin; Outcome; Patients; Personal Satisfaction; Research; Research Personnel; Resources; Scanning; Schizophrenia; Source; Speed; Temporal Lobe; Testing; United States National Institutes of Health; brain volume; cohort; concept; gray matter; improved; myelination; novel; theories; transmission process; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Magnetic resonance imaging has shown that normal brain development continues into the mid-to-late 40's when maximal white matter volumes are reached in the frontal and temporal lobes. This confirms postmortem evidence suggesting that myelination of these brain areas continues into the 40's. Myelin is crucial for normal brain function because it increases the speed of axonal transmission. The increase in myelination is well regulated and occurs in concert with a decrease in gray matter volume resulting in a constant brain volume in adulthood. Schizophrenia is believed to be a disease caused in part by abnormal brain development. We observed that when examined crossectionally, brain development was dysregulated in adult schizophrenic subjects with an absence of normal myelination in adulthood. This project will examine gray and white matter volume changes in schizophrenia and normal adults prospectively by rescanning cohorts of subjects that were initially scanned 5 and 11 years ago. The project will more definitively test the theory that in schizophrenia, brain development is dysregulated in adulthood and will examine whether patients that have a poor outcome are particularly likely to suffer from this developmental problem in adulthood. If confirmed, the prevailing concept of a fixed and therefore unreparable brain developmental problem causing all schizophrenia will be surpassed. This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 磁共振成像显示，正常的大脑发育会持续到 40 多岁中后期，此时额叶和颞叶的白质体积达到最大。这证实了尸检证据表明这些大脑区域的髓鞘形成持续到 40 多岁。髓磷脂对于正常的大脑功能至关重要，因为它可以提高轴突传输的速度。髓鞘形成的增加受到良好调节，并且与灰质体积的减少同时发生，从而导致成年期大脑体积恒定。精神分裂症被认为是一种部分由大脑发育异常引起的疾病。我们观察到，当进行横断面检查时，成年精神分裂症患者的大脑发育失调，成年后缺乏正常的髓鞘形成。该项目将通过重新扫描 5 年前和 11 年前最初扫描的受试者队列，前瞻性地检查精神分裂症患者和正常成年人的灰质和白质体积变化。该项目将更明确地测试精神分裂症患者成年后大脑发育失调的理论，并将研究结果不佳的患者是否特别有可能在成年后遭受这种发育问题。如果得到证实，那么流行的观念将被超越，即导致所有精神分裂症的原因是固定的、因此无法修复的大脑发育问题。这将改变我们对如何治疗这种疾病的概念，改变其终生病程的可行性，并将鼓励开发新的药物干预措施来改善髓鞘形成。