ARCHAEAL RNA LIGASE

古细菌RNA连接酶

• 批准号: 8171323
• 负责人: DIETER SOLL
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171323
• 关键词: Animals; Archaeal RNA; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Human; Human Identifications; Institution; Life; Ligase; Ligation; Literature; Pathway interactions; Pharmaceutical Preparations; RNA; RNA Ligase (ATP); RNA Splicing; Research; Research Personnel; Resources; Source; Transfer RNA; Tropical Disease; Trypanosoma; United States National Institutes of Health; Yeasts; pathogen; tRNA Ligase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In life two different RNA ligation pathways involved in RNA splicing can be pinpointed. The yeast type and the animal/archaeal type ligation pathway. While human mainly utilize the animal type RNA ligation pathway, many pathogens like Leihsmania and Trypanosome rely on the yeast-type tRNA ligation pathway. Hence the yeast type tRNA ligase is a good target to develop a medication against several tropical diseases. Identification of the archaeal RNA ligase should inspire the identification of the human tRNA ligase which has been described in literature as very unstable.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在生活中，可以确定涉及RNA剪接的两种不同的RNA连接途径。酵母类型和动物/古细菌型连接途径。尽管人类主要利用动物型RNA连接途径，但许多病原体（如Leihsmania和Turpanosom）都依赖于酵母类型的TRNA连接途径。因此，酵母类型tRNA连接酶是针对多种热带疾病开发药物的好靶标。 古细菌RNA连接酶的识别应激发人类tRNA连接酶的识别，这在文献中被描述为非常不稳定。