CS DOMAIN OF THE ESSENTIAL H/ACA RNP ASSEMBLY PROTEIN SHQ1

必需 H/ACA RNP 组装蛋白 SHQ1 的 CS 结构域

• 批准号: 8169256
• 负责人: JULI FEIGON
• 金额: $ 0.12万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169256
• 关键词: Biogenesis; Complex; Computer Retrieval of Information on Scientific Projects Database; Defect; Funding; Grant; Institution; Metabolism; N-terminal; Names; Proteins; RNA Processing; Research; Research Personnel; Resources; Ribonucleoproteins; Ribosomal RNA; Sequence Homology; Small Nucleolar RNA; Small Nucleolar Ribonucleoproteins; Source; Telomerase RNA Component; United States National Institutes of Health; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. H/ACA ribonucleoprotein particles are essential for ribosomal RNA and telomerase RNA processing and metabolism. Shq1p has been identified as an essential eukaryotic H/ACA snoRNP biogenesis and assembly factor. Shq1p is postulated to be involved in the early biogenesis steps of H/ACA snoRNP complexes, and Shq1p depletion leads to a specific decrease in H/ACA snoRNA levels and to defects in ribosomal RNA processing. Shq1p contains two predicted domains: an N-terminal CS (named after CHORD-containing proteins and SGT1) or HSP20-like domain, and a Cterminal region of high sequence homology called the Shq1 domain

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 H/ACA 核糖核蛋白颗粒对于核糖体 RNA 和端粒酶 RNA 的加工和代谢至关重要。 Shq1p 已被确定为重要的真核 H/ACA snoRNP 生物发生和组装因子。据推测，Shq1p 参与 H/ACA snoRNP 复合物的早期生物发生步骤，并且 Shq1p 耗竭会导致 H/ACA snoRNA 水平的特异性降低以及核糖体 RNA 加工的缺陷。 Shq1p 包含两个预测结构域：一个 N 端 CS（以包含 CHORD 的蛋白质和 SGT1 命名）或 HSP20 样结构域，以及一个具有高序列同源性的 C 端区域（称为 Shq1 结构域）