STRUCTURAL NEUROIMAGING CORE

结构神经影像核心

• 批准号: 8171126
• 负责人: TERRY L. JERNIGAN
• 金额: $ 0.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171126
• 关键词: Autopsy; Brain; Brain imaging; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Consultations; Data; Development; Diffusion; Disease; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Generations; Grant; HIV encephalitis; Image; Image Analysis; Institution; Laboratories; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Measurable; Mentorship; Methods; Modality; Monitor; Nature; Participant; Pilot Projects; Population; Research; Research Infrastructure; Research Personnel; Resources; Source; Structure; Students; Techniques; Training; Training Programs; United States National Institutes of Health; Work; brain morphology; brain tissue; in vivo; method development; neuroimaging; programs; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this Core are: 1) To assist in characterizing study participants, by providing information about gross brain morphology, with a particular emphasis on neuroanatomical abnormalities present late in the capabilities to studies requiring detailed regional neuroanatomic characterization; 3) To support, with consultation; 3) To support, with consultation and generation of sMRI data for pilot studies, new research initiatives employing neuroimaging techniques, such as MR Spectroscopy (MRS), MR diffusion imaging, and functional MRI (fMRI); 4) To provide a liaison between HNRC investigators and two associated neuroimaging programs: (a) the Brain Image Analysis Laboratory (BIAL), a (REAP), a multi-investigator core infrastructure and training program focusing on applications of fMRI in dementing disorders (T. Jernigan, P.I.); 5) To provide mentorship, consultation, and training in neuroimaging to students and junior investigators affiliated with the HNRC. The Core will support ongoing work investigating the nature and regional distribution of HIV-related brain abnormalities measurable in vivo (with sMRI data), as well as new work aimed at developing more sensitive and more efficient means of monitoring HIV-related CNS dysfunction with other neuroimaging modalities (e.g., fMRI, MR Spectroscopy, etc.). The Core will also focus on new method development targeting the specific abnormalities present in this population, including the development of: more fully automated image-analytic methods for assessment of brain structure from MRI volumes; maps of the distribution of brain tissue anomalies associated with CDC-C3 status and ultimately, with autopsy-verified HIV encephalitis (HIVE); and more sophisticated methods for characterizing prevalent MRI abnormalities in cerebral white matter.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 该核心的主要目标是：1）通过提供有关大脑形态的信息来帮助表征研究参与者，并特别强调神经解剖学异常在后面存在的神经解剖学异常，以进行需要详细的区域神经植物学特征的研究； 3）支持，并进行咨询； 3）为支持和生成用于试点研究的SMRI数据，采用神经影像学技术的新研究计划，例如MR光谱法（MRS），MR扩散成像和功能性MRI（fMRI）； 4）在HNRC研究者和两个相关的神经影像学方面之间提供联络：（a）大脑图像分析实验室（BIAL），A（REAP），A（REAP），一个多Investigator核心基础设施和培训计划，重点介绍FMRI在痴呆障碍中的应用（ T. Jernigan，P.I。）； 5）向隶属于HNRC的学生和初级调查人员提供神经影像学的指导，咨询和培训。该核心将支持正在进行的工作，以调查可在体内可测量的HIV相关脑异常的性质和区域分布（具有SMRI数据），以及旨在开发与其他与其他与其他CNS功能障碍一起开发更敏感，更有效的手段的新工作神经影像模式（例如fMRI，MR光谱等）。核心还将着重于针对该人群中存在的特定异常的新方法开发，包括：更完全自动化的图像分析方法，用于评估MRI体积的大脑结构；与CDC-C3状态相关的脑组织异常分布的图，最终与尸检验证的HIV脑炎（HIVE）；以及更复杂的方法来表征脑白质中普遍的MRI异常。