SINGLE PARTICLE RECONSTRUCTION SOFTWARE DEVELOPMENT (EMAN)

单粒子重建软件开发（EMAN）

• 批准号: 8168523
• 负责人: STEVEN J LUDTKE
• 金额: $ 13.98万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168523
• 关键词: 3-Dimensional; Algorithms; Area; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Funding; Generic Drugs; Grant; Image; Individual; Institution; Process; Research; Research Personnel; Resolution; Resources; Source; Techniques; United States National Institutes of Health; image processing; macromolecular assembly; particle; reconstruction; software development; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. EMAN is a software suite for performing single particle reconstructions. Images of individual molecules or macromolecular assemblies are processed to produce 3-D reconstructions. This toolkit also contains tools for 2-D and dynamics analysis as well as generic image processing. While the core development of EMAN/EMAN2 is funded by an independent R01, under P41 support we continue to develop new algorithms to extend the resolution of the reconstructions possible using this technique, and to explore new research areas, such as using single particle analysis for studying macromolecular dynamics.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 EMAN是用于执行单个粒子重建的软件套件。对单个分子或大分子组件的图像进行处理以产生3-D重建。该工具包还包含用于2-D和动态分析的工具以及通用图像处理。尽管EMAN/EMAN2的核心发展由独立的R01资助，但在P41支持下，我们继续开发新的算法，以扩展使用该技术的重建解决方案，并探索新的研究领域，例如使用单个粒子分析来研究Macromolocular Dynamics。