Functional Assessment Core

功能评估核心

• 批准号: 8122862
• 负责人: Gregory D. Cartee
• 金额: $ 9.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122862
• 关键词: Academic Medical Centers; Address; Animals; Biology of Aging; Biomedical Research; Cellular biology; Charge; Core Facility; DNA Sequence; DNA Sequencing Facility; Discipline; Faculty; Flow Cytometry; Funding; Genomics; Goals; Hybridomas; Image Analysis; Laboratories; Laboratory Study; Libraries; Mass Spectrum Analysis; Michigan; Microscopy; Molecular Biology; Phenotype; Physiology; Research; Research Support; Resources; Science; Scientist; Services; Shock; System; Universities; Viral Vector; Work; cost; experience; functional group; medical specialties; meetings; member; metabolomics; molecular imaging; protocol development; small hairpin RNA

Functional Assessment Core: Greg Cartee, Director The Functional Assessment Core (FAC) will promote the effective use of UM's rich set of Biomedical Research Core laboratories for studies in the cell biology, physiology, and molecular biology of aging. Rationale and goals: The University of Michigan has an exceptionally diverse range of well equipped research support cores, each supervised by experienced faculty members and employing highly skilled technicians, which facilitate biomedical science in multiple disciplines by providing resources beyond the reach of any one laboratory group. These Cores are in general subsidized by the University, and each charges a UM-certified recharge rate for its services. Of the more than fifty such Core Labs available on the UM campus, several are particularly likely to be valuable for Shock Center scientists. These include the Affymetrix and Microarray Core, the Animal Phenotyping Core Laboratory, the Biomedical Mass Spectrometry Facility, the Center for Integrative Genomics, the Center for Molecular Imaging, the DNA Sequencing Core, the Flow Cytometry Core, the Hybridoma Core, the Metabolomics Core, the Microscopy and Image Analysis Laboratory, the new shRNA Library Core, and the Viral Vector Core. Rather than attempt to duplicate or compete with any of these superb specialty groups, the FAC will work with UM biogerontologists to develop projects that make optimal use of one or more of these UM Cores, and then pay for 40% of the costs for FAC-approved projects. This system differs from that used by "Functional Assessment Cores" at some other Nathan Shock Centers. At NSCs that are not affiliated with major academic medical centers, it may well be necessary to use NSC funds to set up specialized core facilities to meet research objectives that could not otherwise be addressed. At larger research centers like UM, however, the challenge is not to develop such Core facilities from scratch, but rather to promote the use of these well-established facilities in support of biogerontological research. By providing guidance to NSC faculty on protocol development and Core resources, and by helping to pay for the costs of use of the UM Core facilities for selected projects, the FAC will leverage its limited funds to support research of special value and high relevance to the biology of aging.

功能评估核心：总监Greg Cartee 功能评估核心（FAC）将促进UM丰富的生物医学研究核心实验室的有效利用，用于细胞生物学，生理学和衰老分子生物学的研究。 基本原理和目标：密歇根大学拥有异常多样的功能齐全的研究支持核心，每个人都受到经验丰富的教职员工的监督，并雇用了高技能的技术人员，这通过提供超出任何一个实验室组的资源来促进多个学科的生物医学科学。这些核心通常由大学补贴，每个核心都为其服务收取UM认证的补给率。在UM校园可用的五十多个此类核心实验室中，有些人特别有可能对冲击中心科学家有价值。这些包括Affymetrix和微阵列 核心，动物表型核心实验室，生物医学质谱设施，综合基因组学中心，分子成像中心，DNA测序核心，流式细胞术核心，杂交瘤核心，杂交核心，代谢组核心，显微镜和图像分析实验室，新的Shrna库核心，新的Shrna库核心和病毒元素。 FAC将与UM生物生态学家合作开发最佳使用这些UM核心的项目，而不是试图与任何这些出色的专业团体复制或竞争这些精湛的专业团体，而是为FAC批准的项目支付40％的费用。 该系统与其他一些内森冲击中心的“功能评估核心”所使用的系统不同。 在不隶属于主要学术医疗中心的NSC，很可能有必要使用NSC资金建立专业的核心设施来实现无法解决的研究目标。 但是，在UM等较大的研究中心，面临的挑战不是要从头开始开发此类核心设施，而是要促进这些良好的设施来支持生物生态学研究。通过向NSC教师提供有关协议开发和核心资源的指导，并通过帮助支付用于选定项目的UM核心设施的使用成本，FAC将利用其有限的资金来支持特殊价值的研究和与衰老生物学的高度相关性。