LSUHSC COBRE: CORE 1: IMMUNOLOGY & CELL ANALYSIS

LSUHSC COBRE：核心 1：免疫学

• 批准号: 8168427
• 负责人: AUGUSTO C. OCHOA
• 金额: $ 10.28万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168427
• 关键词: Cell Cycle; Cell Separation; Cell physiology; Cells; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Development; Equipment; Flow Cytometry; Funding; Grant; Histology; Immunology; Institution; Nuclear Translocation; Phosphorylation; Production; Protein Tyrosine Kinase; Research; Research Personnel; Resources; Signal Transduction; Source; Techniques; Tissues; United States National Institutes of Health; cytokine; cytotoxicity; peripheral blood; release of sequestered calcium ion into cytoplasm; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Immunology and Cell Analysis Core (ICAC) is central to the development of the scientific projects proposed in this COBRE. It will provide access to equipment and technical support to the PJI. The Immunology and Cell Analysis Core has available cellular techniques including separation of cell subpopulations from peripheral blood and tissues, phenotypic characterization of the cells by flow cytometry and histology and characterization of cell functions including proliferation, cell cycle analysis, cytokine production and cytotoxicity. In addition, the ICAC provides the capacity to study cell signaling such as tyrosine kinase phosphorylation, calcium flux and activation and translocation of nuclear transcription factors.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 免疫学和细胞分析核心 (ICAC) 是本 COBRE 中提出的科学项目开发​​的核心。它将为 PJI 提供设备和技术支持。免疫学和细胞分析核心拥有可用的细胞技术，包​​括从外周血和组织中分离细胞亚群、通过流式细胞术和组织学对细胞进行表型表征，以及细胞功能表征（包括增殖、细胞周期分析、细胞因子产生和细胞毒性）。此外，ICAC 还提供了研究细胞信号传导的能力，例如酪氨酸激酶磷酸化、钙通量以及核转录因子的激活和易位。