UHI COBRE: P1: MOL EPIDEMIOL & NATURAL HISTORY OF HPV IN HETEROSEXUAL MEN

UHI COBRE：P1：MOL 流行病

• 批准号: 8168408
• 负责人: BRENDA Y HERNANDEZ
• 金额: $ 60.83万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-16 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168408
• 关键词: Address; Adult; Age; Alcohol consumption; Asia; Cells; Centers of Research Excellence; Cervix carcinoma; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Contraceptive Usage; DNA; Data; Funding; Future; Genital Human Papilloma Virus Infection; Genitalia; Grant; Heterosexuals; High Prevalence; Human Papillomavirus; Human papilloma virus infection; Incidence; Infection; Institution; Integration Host Factors; Knowledge; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Molecular Epidemiology; Natural History; Prevalence; Prevention; Prevention strategy; Recording of previous events; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Sexually Transmitted Diseases; Source; Testing; Tobacco; United States National Institutes of Health; Urethra; Variant; Viral; Viral Load result; Woman; cohort; expectation; improved; innovation; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human papillomavirus (HPV) is a major cause of sexually transmitted infections (STI) and is the principal cause of cervical cancers worldwide. In much of the Asia-Pacific region, cervical carcinoma ranks first among all cancers in women. Although considerable data are now available about HPV infections in women, almost nothing is known about the natural history of HPV infections among heterosexual men. Lack of such knowledge has impeded progress in the prevention and control of HPV infection in women. The objective of this research project is to determine the molecular epidemiology and natural history of HPV infection in heterosexual men. Our central hypothesis is that, as in women, HPV is a common (high prevalence and incidence) but usually transient infection in heterosexual men. We further posit that young age and low HPV viral level will be associated with transient infections, while older age and high HPV viral load will predict viral persistence. The proposed study will test our hypotheses by pursuing the following specific aims: 1. Determine the prevalence and incidence of genital HPV infection in heterosexual adult men. 2. Determine the relative transience and persistence of genital HPV infection in heterosexual adult men. 3. Determine the viral and host factors associated with prevalent, incident, transient, and persistent genital HPV infection in heterosexual adult men. A cohort of 640 adult men will be followed longitudinally at four-month intervals for 24 months. Exfoliated cells from the genitalia (penile shaft, glans/coronal sulcus, urethra) will be analyzed for HPV DNA by PCR. Infections will be characterized by HPV genoyping and variant analysis. Also, we will evaluate information on sexual history and practices, contraceptive use, history of STI, tobacco and alcohol use, and sociodemographic characteristics. The proposed project is innovative, because it addresses a major gap in current knowledge. Our expectations are that we will have a better understanding about the natural history of HPV in men. This newfound knowledge will have a significant impact on improving future prevention strategies for HPV infection.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 人乳头瘤病毒 (HPV) 是性传播感染 (STI) 的主要原因，也是全世界宫颈癌的主要原因。在亚太大部分地区，宫颈癌位居女性所有癌症之首。尽管现在有大量关于女性 HPV 感染的数据，但对异性恋男性 HPV 感染的自然史几乎一无所知。 缺乏这方面的知识阻碍了女性 HPV 感染预防和控制的进展。该研究项目的目的是确定异性恋男性中 HPV 感染的分子流行病学和自然史。我们的中心假设是，与女性一样，HPV 在异性恋男性中是一种常见（患病率和发病率很高）但通常是短暂的感染。我们进一步推测，年轻和低 HPV 病毒水平将与短暂感染相关，而老年和高 HPV 病毒载量将预测病毒持续存在。拟议的研究将通过追求以下具体目标来检验我们的假设： 1. 确定异性恋成年男性生殖器 HPV 感染的患病率和发病率。 2. 确定异性恋成年男性生殖器 HPV 感染的相对短暂性和持续性。 3. 确定与异性恋成年男性中普遍、偶然、短暂和持续性生殖器 HPV 感染相关的病毒和宿主因素。 将对 640 名成年男性进行为期 24 个月的纵向随访，每隔四个月一次。将通过 PCR 对生殖器（阴茎干、龟头/冠状沟、尿道）脱落细胞进行 HPV DNA 分析。将通过 HPV 基因分型和变异分析来表征感染。此外，我们还将评估有关性史和性行为、避孕药具使用、性传播感染史、烟草和酒精使用以及社会人口特征的信息。拟议的项目具有创新性，因为它解决了当前知识的主要空白。我们期望我们能够更好地了解男性 HPV 的自然史。这一新发现的知识将对改善未来 HPV 感染的预防策略产生重大影响。