COLLABORATIVE GRANT - MRI GUIDED PHOTOIMMUNOTHERAPY

合作资助 - MRI 引导光免疫治疗

• 批准号: 8167526
• 负责人: WEI R CHEN
• 金额: $ 6.49万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167526
• 关键词: Animal Model; Biological; Biological Assay; Biophotonics; Carbon Nanotubes; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Dyes; Funding; Grant; Image; Immunotherapy; Indocyanine Green; Institution; Lasers; Light; Magnetic Resonance; Methods; Nanotechnology; Nanotubes; Neoplasm Metastasis; Pharmaceutical Preparations; Polymers; Reaction; Regimen; Research; Research Personnel; Resources; Source; Therapeutic; Thermometry; Tissues; United States National Institutes of Health; cancer therapy; glycated chitosan; imaging modality; in vivo; novel; surfactant; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this project is to develop a novel method, photoimmunotherapy, combining biophotonics and nanotechnology, for treatment of metastatic tumors, using magnetic resonance thermometry (MRT) guidance for its selective photothermal interaction. The Pis have developed laser immunotherapy using a near-infrared laser, indocyanine green (ICG, a chemical dye), and glycated chitosan (GC, a polymer) for treatment of metastatic tumors. Recently, the Pis discovered that GC was an excellent surfactant for single-walled carbon nanotubes (SWNTs), which can strongly absorb light of 980-nm wavelength, to which biological tissue is almost transparent. It is hypothesized that GC-SWNT, when administered to the target tissue and activated by laser light of appropriate wavelength, could induce selective photothermal and immunological reactions for treatment of metastatic tumors. Furthermore, nanotubes in the proposed photoimmunotherapy could also be used as carriers of other therapeutic drugs as well as imaging contrast agents. Therefore, photoimmunotherapy, combining nanotechnology could potentially become a multi-modality, imaging guided regimen for cancer treatment. We propose to achieve the following specific aims during this one-year collaborative project: 1. To determine the selective thermal effects of the laser-GC-SWNTcombination, using MRT; 2. To determine the in vivo effects of laser-GC-SWNT in the treatment ofmetastatic tumors, using animal models; 3. To determine the immunological effects induced by the laser-GC-SWNT treatment, using immunological assays. The successful completion of this project will pave the way for further research to develop photoimmunotherapy

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的长期目的是使用磁共振温度计（MRT）针对其选择性光热相互作用的指南，开发一种新方法，即摄影疗法，生物植物学和纳米技术来治疗转移性肿瘤。 PIS使用近红外激光，吲哚羟氨酸绿（ICG，化学染料）和糖化的壳聚糖（GC，聚合物）来治疗转移性肿瘤。最近，PIS发现GC是单壁碳纳米管（SWNT）的出色表面活性剂，可强烈吸收980 nm波长的光，生物组织几乎透明。 假设GC-SWNT对靶组织施用并被适当波长的激光激活时，可能会诱导选择性的光热和免疫反应以治疗转移性肿瘤。此外，拟议的摄影疗法中的纳米管也可以用作其他治疗药物的携带者以及成像对比剂。因此，将纳米技术结合使用的摄影疗法可能会成为一种多模式的癌症治疗方案。 我们建议在这个为期一年的协作项目中实现以下特定目标： 1。使用MRT确定激光-GC-SWNTCOMBIAN的选择性热效应； 2。使用动物模型来确定激光GC-SWNT在对象肿瘤治疗中的体内效应； 3。使用免疫学分析确定激光GC-SWNT治疗引起的免疫学效应。 该项目的成功完成将为进一步的研究铺平道路，以开发摄影疗法