LSU VETERINARY COBRE: PATHOGENESIS OF BORRELIA BURGDORFERI

路易斯安那州立大学兽医 COBRE：伯氏疏螺旋体的发病机制

• 批准号: 8167885
• 负责人: FANG-TING LIANG
• 金额: $ 19.98万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167885
• 关键词: Acrodermatitis; Aftercare; Animals; Arthritis; Bacteria; Borrelia burgdorferi; Carditis; Computer Retrieval of Information on Scientific Projects Database; Contracts; Cutaneous; Development; Disease; Dose; Europe; Funding; Grant; Hour; Human; Immune response; In Vitro; Infection; Institution; Lesion; Lyme Arthritis; Lyme Disease; Mus; Neurologic; North America; Organism; Pathogenesis; Patients; Phagocytes; Research; Research Personnel; Resources; Source; Syndrome; System; Time; United States; United States National Institutes of Health; erythema migrans; extracellular; microbial; pathogen; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project studies the pathogenesis of Borrelia burgdorferi that causes Lyme disease, the most common vectorborne illness in North America and Europe. Over 20,000 people contract Lyme disease annually in the United States alone. Lyme disease is a multi-system disorder that can result in arthritis, neurological abnormalities, carditis and cutaneous lesions such as erythema migrans and acrodermatitis chronica atrophicans. Up to 10% Lyme disease patients may develop post-treatment Lyme syndrome, a mysterious illness that can not be cured. As a slow growing extracellular bacterium with a doubling time of approximately 8 hours in the best in vitro conditions, B. burgdorferi has a 50% infectious dose (ID50) of less than 100 organisms in the murine host, and can also cause persistent infection despite the development of vigorous immune responses against the pathogen, making itself one of the most invasive microbial pathogens in both humans and animals. The focus is on the following three aspects of the pathogenesis of B. burgdorferi. 1. How B. burgdorferi evades initial elimination by phagocytes 2. How B. burgdorferi evades specific humoral responses 3. How B. burgdorferi causes Lyme arthritis

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目研究导致莱姆病的伯氏疏螺旋体的发病机制，莱姆病是北美和欧洲最常见的媒介传播疾病。仅在美国，每年就有超过 20,000 人感染莱姆病。莱姆病是一种多系统疾病，可导致关节炎、神经系统异常、心脏炎和皮肤病变，例如游走性红斑和慢性萎缩性肢端皮炎。高达 10% 的莱姆病患者可能会在治疗后出现莱姆综合征，这是一种无法治愈的神秘疾病。作为一种生长缓慢的胞外细菌，在最佳体外条件下倍增时间约为 8 小时，伯氏疏螺旋体对小鼠宿主体内少于 100 个生物体的感染剂量 (ID50) 为 50%，并且即使在针对病原体产生强烈的免疫反应，使其成为人类和动物中最具侵入性的微生物病原体之一。重点关注伯氏疏螺旋体发病机制的以下三个方面。 1. 伯氏疏螺旋体如何逃避吞噬细胞的初步消除 2. 伯氏疏螺旋体如何逃避特定的体液反应 3. 伯氏疏螺旋体如何引起莱姆关节炎