COBRE: UNE MED CTR: CORE C: HISTOLOGY CORE

COBRE：UNE MED CTR：核心 C：组织学核心

• 批准号: 8168357
• 负责人: Kay-Uwe Wagner
• 金额: $ 8.92万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168357
• 关键词: Antibodies; Area; Arts; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Data; Development; Equipment; Extramural Activities; Funding; Generations; Grant; Histology; Human Resources; Individual; Institution; Laboratories; Mentors; Methodology; Mission; Nebraska; Phenotype; Procedures; Reagent; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; Source; Standardization; Technical Expertise; Time; Training; United States National Institutes of Health; cost; experience; improved; information framework; programs; quality assurance; success; web site

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Histology Core has the mission to serve the investigators of the COBRE Program with their needs in specialized morphological and histological analysis of neurosensory development and relevant mousephenotypes. A Core Facility for histology offers several advantages to the COBRE investigators and the COBRE Program: 1) Enrichment of Resources: The establishment of the Core Facility with expert personnel will provide the individual investigators with a multitude of services, equipment resources and technical expertise that is not readily available within their individual laboratories. This will significantly broaden the depth of the individual research projects and support the development of state-of-the-art and technologically comprehensive research programs within the individual junior investigators' laboratories. 2) Efficiency of Personnel and Cost Management: The concentration of such resources within the Core allows for better efficiency and standardization in the usage of typically costly reagents, such as for example, specialized antibodies. Furthermore, the involvement of the highly trained and experienced Director of Phenotyping Services at UNMC, Ms. M. Anita Jennings, will reduce the need for each PI to allocate their personnel to methodologies that require extensive training and time in order to be proficiently carried out. In addition, the use of common reagents will better allow investigators from the different laboratories to compare and interpret results. 3) Quality Assurance, Mentoring and Information Flow: Scientifically, the Core will enable a standardization of procedures, of flow of information, and of frameworks for interpretation that will greatly enhance the infrastructure for success of individual projects through common quality assurance, data generation and interpretation standards. In this way, investigators benefit from the combined expertise generated through all of the projects. Most importantly, information flow will be improved through the use of a common Website for access to the Histology Core that integrates the efforts of individual investigators along common themes. 4) Enhancement of Infrastructure: The long-term objective of the COBRE, namely, to establish a critical mass of investigators on one area through the Center for Neurosensory Development in Nebraska, will also be served by the Core Facility. The availability of a specialized Histology Core Facility will increase the competitiveness of COBRE investigators for extramural funding, serve in retention of funded investigators, and attract and recruit new investigators into the Center for Neurosensory Development.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 组织学核心的使命是为 COBRE 计划的研究人员提供服务，满足他们对神经感觉发育和相关小鼠表型的专门形态学和组织学分析的需求。组织学核心设施为 COBRE 研究人员和研究人员提供了多项优势 COBRE 计划： 1) 资源丰富：由专家人员建立的核心设施将为个体研究者提供其个体实验室中不易获得的多种服务、设备资源和技术专业知识。这将显着拓宽各个研究项目的深度，并支持最先进的技术的发展 各个初级研究人员实验室内的综合研究项目。 2) 人员效率和成本管理：将此类资源集中在核心内可以提高通常昂贵试剂（例如专门试剂）的使用效率和标准化。 抗体。此外，UNMC 训练有素且经验丰富的表型服务总监 M. Anita Jennings 女士的参与，将减少每个 PI 将其人员分配给需要大量培训和时间才能熟练执行的方法的需要。 。此外， 使用通用试剂将更好地允许来自不同实验室的研究人员比较和解释结果。 3) 质量保证、指导和信息流：从科学上讲，核心将实现程序、信息流和解释框架的标准化，这将极大地促进 通过共同的质量保证、数据生成和解释标准，加强各个项目成功的基础设施。通过这种方式，研究人员可以从所有项目产生的综合专业知识中受益。最重要的是，通过使用一个通用网站访问组织学核心，信息流将得到改善，该网站整合了各个研究人员的努力 共同的主题。 4) 加强基础设施：COBRE 的长期目标，即通过内布拉斯加州神经感觉发展中心在某一领域建立足够数量的研究人员，核心设施也将为其提供服务。专门的组织学核心设施的可用性将提高 COBRE 研究人员获得外部资金的竞争力，有助于留住受资助的研究人员，并吸引和招募新的研究人员进入神经感觉发展中心。