PROSPECTIVE HUNTINGTON AT RISK OBSERVATIONAL STUDY (PHAROS)

前瞻性亨廷顿风险观察研究 (PHAROS)

• 批准号: 8166871
• 负责人: GUERRY Marie PEAVY
• 金额: $ 0.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166871
• 关键词: Age; Age of Onset; Attitude; Belief; Biological Markers; Clinical; Computer Retrieval of Information on Scientific Projects Database; DNA Markers; Disease; Funding; Grant; Huntington Disease; Individual; Institution; Measures; Observational Study; RNA; Research; Research Personnel; Resources; Risk; Sensitivity and Specificity; Source; United States National Institutes of Health; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To follow a group of individuals at risk for Huntington's Disease (HD) longitudinally (1) to establish how many individuals develop signs of the disease over the study period, (2) to identify the earliest signs of the illness and the age at which they begin, (3) to examine the accuracy of current clinical measures used in detecting the onset of HD, (4) to ascertain possible factors such as potential environmental modifiers and personal beliefs and attitudes influencing age of onset and clinical precursors predictive of onset of manifest HD, and (5) to examine the specificity and sensitivity of markers of DNA and RNA damage as potential state biomarkers for HD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 跟随一群有纵向亨廷顿疾病风险（HD）的人（1）确定在研究期间有多少个人出现疾病的迹象，（2）确定疾病的最早迹象和开始的年龄（3），以检验当前临床量的临床态度和诸如检测HD的临床影响的准确性（3）预测明显HD发作的发作和临床前体，以及（5）检查DNA和RNA损伤标记物的特异性和灵敏度，作为HD的潜在状态生物标志物。