CLINICAL TRIAL: INVASIVE ASPERGILLOSIS DIAGNOSIS AND PATHOGENESIS

临床试验：侵袭性曲霉病的诊断和发病机制

• 批准号: 8174531
• 负责人: Scott G Filler
• 金额: $ 0.41万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174531
• 关键词: Affect; Antifungal Therapy; Aspergillosis; Aspergillus fumigatus; Blood Vessels; Cells; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Endothelial Cells; Experimental Models; Funding; Goals; Grant; Harvest; Human; Immunocompromised Host; Infection; Institution; Invaded; Investigation; Methods; Mothers; Mycoses; Organism; Pathogenesis; Patients; Process; Research; Research Personnel; Research Project Grants; Resources; Source; Umbilical Cord Blood; Umbilical cord structure; United States National Institutes of Health; Vaginal delivery procedure; Veins; Work; clinically relevant; mortality; novel; prevent; tissue culture

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Invasive aspergillosis is a fungal infection that primarily affects immunocompromised patients. Most cases of invasive aspergillosis are caused by Aspergillus fumigatus. There is a critical need for the identification of novel targets for antifungal therapies that can prevent this organism from infecting people. The purpose of this research project is to develop clinically relevant experimental models to study the mechanisms by which A. fumigatus causes infection. As part of these investigations, we plan to study the interactions of A. fumigatus with endothelial cells. These cells form the inner lining of the blood vessels. The long-range goal of this research is to understand how A. fumigatus invades, damages, and activates these cells so that methods to block this process can be developed. This work is important because the mortality of patients with invasive aspergillosis is approximately 50%, even with currently available therapy. For the proposed studies, the endothelial cells will be harvested from the veins within human umbilical cords and grown in tissue culture. The umbilical cords will be obtained after normal vaginal births from uninfected donors. No information about the mother or baby will be collected. The donors of the cords will not be identified and the umbilical cord blood will not be collected.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 侵入性曲霉病是一种真菌感染，主要影响免疫功能低下的患者。 大多数浸润性曲霉病的病例是由烟曲霉引起的。 迫切需要确定可以防止这种生物感染人的抗真菌疗法的新靶标。 该研究项目的目的是开发临床相关的实验模型，以研究烟曲霉引起感染的机制。 作为这些研究的一部分，我们计划研究烟曲霉与内皮细胞的相互作用。 这些细胞形成了血管内壁。 这项研究的远程目标是了解烟曲霉如何入侵，损坏和激活这些细胞，以便可以开发阻断该过程的方法。 这项工作很重要，因为侵入性曲霉病的患者的死亡率约为50％，即使目前可用的治疗也是如此。 对于拟议的研究，内皮细胞将从人脐带中的静脉收获，并在组织培养中生长。 未感染的供体正常阴道分娩后，将获得脐带。 不会收集有关母亲或婴儿的信息。 将无法确定绳索的供体，并且不会收集脐带血。