CLINICAL TRIAL: INVASIVE ASPERGILLOSIS DIAGNOSIS AND PATHOGENESIS

临床试验：侵袭性曲霉病的诊断和发病机制

• 批准号: 8174531
• 负责人: Scott G Filler
• 金额: $ 0.41万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174531
• 关键词: Affect; Antifungal Therapy; Aspergillosis; Aspergillus fumigatus; Blood Vessels; Cells; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Endothelial Cells; Experimental Models; Funding; Goals; Grant; Harvest; Human; Immunocompromised Host; Infection; Institution; Invaded; Investigation; Methods; Mothers; Mycoses; Organism; Pathogenesis; Patients; Process; Research; Research Personnel; Research Project Grants; Resources; Source; Umbilical Cord Blood; Umbilical cord structure; United States National Institutes of Health; Vaginal delivery procedure; Veins; Work; clinically relevant; mortality; novel; prevent; tissue culture

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Invasive aspergillosis is a fungal infection that primarily affects immunocompromised patients. Most cases of invasive aspergillosis are caused by Aspergillus fumigatus. There is a critical need for the identification of novel targets for antifungal therapies that can prevent this organism from infecting people. The purpose of this research project is to develop clinically relevant experimental models to study the mechanisms by which A. fumigatus causes infection. As part of these investigations, we plan to study the interactions of A. fumigatus with endothelial cells. These cells form the inner lining of the blood vessels. The long-range goal of this research is to understand how A. fumigatus invades, damages, and activates these cells so that methods to block this process can be developed. This work is important because the mortality of patients with invasive aspergillosis is approximately 50%, even with currently available therapy. For the proposed studies, the endothelial cells will be harvested from the veins within human umbilical cords and grown in tissue culture. The umbilical cords will be obtained after normal vaginal births from uninfected donors. No information about the mother or baby will be collected. The donors of the cords will not be identified and the umbilical cord blood will not be collected.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 侵袭性曲霉病是一种真菌感染，主要影响免疫功能低下的患者。 大多数侵袭性曲霉病是由烟曲霉引起的。 迫切需要确定抗真菌疗法的新靶点，以防止这种生物体感染人类。 该研究项目的目的是开发临床相关的实验模型来研究烟曲霉引起感染的机制。 作为这些研究的一部分，我们计划研究烟曲霉与内皮细胞的相互作用。 这些细胞形成血管的内壁。 这项研究的长期目标是了解烟曲霉如何侵入、损害和激活这些细胞，以便开发出阻止这一过程的方法。 这项工作很重要，因为即使采用目前可用的治疗方法，侵袭性曲霉病患者的死亡率也约为 50%。 对于拟议的研究，将从人脐带内的静脉中收获内皮细胞并在组织培养物中生长。 脐带将从未受感染的捐赠者正常阴道分娩后获得。 不会收集有关母亲或婴儿的信息。 脐带捐献者的身份将不会被识别，脐带血也不会被收集。