CARDIOVASCULAR DISEASE AND DIABETIC NEPHROPATHY

心血管疾病和糖尿病肾病

• 批准号: 8174478
• 负责人: RAJNISH MEHROTRA
• 金额: $ 31.79万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174478
• 关键词: Atherosclerosis; Cardiovascular Diseases; Cardiovascular system; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Diabetic Nephropathy; Funding; Grant; Homocysteine; Homocystine; Individual; Institution; Kidney Diseases; Leptin; Mexican Americans; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Plasma; Prevalence; Research; Research Personnel; Resources; Risk Factors; Serum; Source; United States National Institutes of Health; burden of illness; cohort; coronary artery calcification; ethnic difference; ethnic minority population; heart disease risk; mortality; prospective; socioeconomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of type 2 diabetes is significantly higher in ethnic minorities and these individuals are morel likely to get complications from their type 2 diabetes, including kidney disease. Individuals with kidney disease are more likely to have heart disease; the risk profile as well as the disease burden in Mexican Americans with type 2 diabetes mellitus and kidney disease has never been defined. The study is a prospective, observational, cohort study of Mexican Americans and Non Hispanic Whites with diabetic nephropathy. The purpose of this study is to define the baseline atherosclerotic burden ( as assessed by coronary artery calcification) , the rate of progression of atherosclerotic burden and the total as well as cardiovascular mortality in a cohort of Mexican Americans with diabetic nephropathy and compare it to a cohort of non-Hispanic whites with diabetic nephropathy. Furthermore, the contribution of several risk factors for atherosclerosis to explain the ethnic differences in coronary artery calcification burden will be studied. Two emerging factors (plasma homocysteine and serum leptin levels) as well as several socio-economic variables will be studied to determine their contribution to the ethnic differences in coronary artery calcification burden.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在少数民族中，2型糖尿病的患病率明显更高，这些人可能会从2型糖尿病（包括肾脏疾病）中获得并发症。患有肾脏疾病的人更可能患有心脏病。墨西哥裔美国人患有2型糖尿病和肾脏疾病的风险特征以及疾病负担从未定义。 这项研究是对墨西哥裔美国人和非西班牙裔白人患有糖尿病肾病的前瞻性，观察性的，同类的研究。这项研究的目的是定义基线动脉粥样硬化负担（通过冠状动脉钙化评估），动脉粥样硬化负担的进展率以及墨西哥裔美国人患有糖尿病性肾病的墨西哥群体中的总和心血管死亡率，并与非疾病症的同胞相比，并与之相比。此外，将研究动脉粥样硬化的几个危险因素的贡献，以解释冠状动脉钙化负担的种族差异。将研究两个新兴因素（血浆同型半胱氨酸和血清瘦素水平）以及几个社会经济变量，以确定它们对冠状动脉钙化负担种族差异的贡献。