MULTI-CENTER TRIAL TO EVALUATE HOME-BASED ASSESSMENT METHODS FOR ALZHEIMER DISEA

评估阿尔茨海默病家庭评估方法的多中心试验

• 批准号: 8166928
• 负责人: RUTH MULNARD MCCARGAR
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166928
• 关键词: Alzheimer' s Disease; Clinic; Clinical; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Conduct Clinical Trials; Drops; Funding; Grant; Health Resources; Home environment; Impaired cognition; Individual; Institution; Lead; Medical; Methods; Persons; Prevention; Research; Research Personnel; Resources; Risk; Sample Size; Site; Source; Time; Transportation; United States National Institutes of Health; Visit; base; cost; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is an unmet need for effective, efficient and economical methods for conducting clinical trials to prevent Alzheimer s disease. Traditional in-person visits to a clinic are time consuming and costly and may exclude certain individuals from participation, such as those who are older, or are less mobile or who have significant medical illnesses. These may be the very people who are at greatest risk for cognitive decline, as well as those without financial resources for transportation to a study site. Prevention trials also require long observation periods and these same issues of health, resources, and transportation may cause significant drop out. These obstacles increase expense of clinical trials as they require large sample sizes, costly clinical staff and long observation periods. Thus, home-based assessments may lead to more representative recruitment of those most at risk for decline, better retention and reduced study costs.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 对于进行预防阿尔茨海默病的临床试验的有效、高效和经济的方法的需求尚未得到满足。传统的亲自到诊所就诊既耗时又昂贵，并且可能会将某些人排除在参与之外，例如年龄较大、行动不便或患有严重疾病的人。这些人可能是认知能力下降风险最大的人，也可能是那些没有经济来源前往研究地点的人。 预防试验还需要较长的观察期，而同样的健康、资源和交通问题可能会导致大量退出。这些障碍增加了临床试验的费用，因为它们需要大样本量、昂贵的临床人员和较长的观察期。因此，基于家庭的评估可能会导致对那些最有可能下降的人进行更具代表性的招募，更好的保留并降低研究成本。