CLINICAL TRIAL: ESTROGEN PREVENTION TRIAL

临床试验：雌激素预防试验

• 批准号: 7951032
• 负责人: RUTH MULNARD MCCARGAR
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951032
• 关键词: Alzheimer' s Disease; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Conjugated Estrogens; Dementia; Enrollment; Estrogens; Family history of; Funding; Grant; Institution; National Institute on Aging; New York; Placebo Control; Placebos; Population; Prempro; Prevention; Randomized; Research; Research Personnel; Resources; Site Visit; Source; United States National Institutes of Health; Woman; Work; base; human old age (65+); prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a randomized, placebo-controlled, prevention-type clinical trial supported by the National Institute on Aging for a four-year period of exposure in which women 65 years and older who have a positive family history of dementia are given premarin/prempro (based on uterine status) versus placebo in an effort to prevent the occurence of Alzheimer's disease in a population that is vulnerable by family history. Our current enrollment in the trial is 28 women, and we are still actively enrolling. This trial is supported by an RO-1 to Dr. Mary Sano, who recently moved from Columbia to Mt. Sinai in New York. During the competitive renewal site visit, the RO-1 received a score of 159, and is confident that the funding will continue for another five years to support this ongoing work.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这是一个随机，安慰剂控制的，预防型临床试验，该试验由美国国家衰老研究所（National Institute of Nation Instute of Aging）进行了四年的暴露期，其中65岁及以上的女性具有积极的痴呆症家族史（Premarin/Premarin/prempro）（基于子宫状态）对安慰剂，以防止因alzheimer ersey的病史而努力，以防止其病人的疾病。 我们目前参加审判的人数是28名妇女，我们仍在积极入学。 该试验得到了RO-1的支持，玛丽·萨诺（Mary Sano）博士最近从哥伦比亚搬到纽约西奈山。 在竞争性更新现场访问期间，RO-1的得分为159，并确信资金将继续持续五年，以支持这项正在进行的工作。