SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION

交感神经系统对细胞粘附的调节

• 批准号: 8166820
• 负责人: Paul J Mills
• 金额: $ 2.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166820
• 关键词: Antihypertensive Agents; Blood Pressure; Cell Adhesion; Chemotaxis; Computer Retrieval of Information on Scientific Projects Database; Diet; Exercise; Exercise stress test; Funding; Grant; Hypertension; ITGAM gene; Inflammation; Institution; Integrins; Interleukin-6; Intervention; Leukocytes; Patients; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Psyche structure; Regulation; Research; Research Personnel; Resources; Rest; Selectins; Source; Stress; Sympathetic Nervous System; Tumor Necrosis Factor-alpha; United States National Institutes of Health; human TNF protein; leukocyte activation; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will examine the effects of a 12-week exercise intervention and a 12-week exercise plus diet intervention on inflammation and cell adhesion in 150 patients with hypertension (blood pressure >140/90 mm Hg but <179/109 mm Hg) and prehypertensive (blood pressure >120/80 mm Hg but <140/90 mm Hg) who are currently not on anti-hypertensive medication. Prior to and following the interventions, we will assess resting and stress-induced (mental stressor and treadmill exercise testing) changes in circulating levels of CRP, IL-6, TNF-alpha, sICAM-1, sE-selectin, expression of the ¿?2-integrin subunits CD11a and CD11b on leukocytes, leukocyte activation (pseudopod formation), and peripheral blood mononuclear cell (PBMC) chemotaxis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 中心，不一定是研究者的机构。 我们将检查 12 周运动干预和 12 周运动加饮食干预对 150 名高血压患者（血压 >140/90 mm Hg 但 <179/109 mm Hg）和高血压前期患者炎症和细胞粘附的影响。 （血压>120/80 mm Hg但<140/90 mm Hg）在干预之前和之后目前未服用抗高血压药物，我们将评估静息和压力引起的（精神压力源和跑步机运动测试）CRP、IL-6、TNF-α、sICAM-1、sE-选择素的循环水平的变化，以及 ¿ β2-整合素亚基 CD11a 和 CD11b 对白细胞、白细胞活化（伪足形成）和外周血单核细胞 (PBMC) 趋化作用的影响。