SYMPATHETIC NERVOUS SYSTEM REGULATION OF CELL ADHESION

交感神经系统对细胞粘附的调节

• 批准号: 7950960
• 负责人: Paul J Mills
• 金额: $ 6.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950960
• 关键词: Antihypertensive Agents; Blood Pressure; Cell Adhesion; Chemotaxis; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diet; Exercise; Exercise stress test; Funding; Grant; Hypertension; ITGAM gene; Inflammation; Institution; Integrins; Interleukin-6; Intervention; Leukocytes; Patients; Peripheral Blood Mononuclear Cell; Pharmaceutical Preparations; Psyche structure; Regulation; Research; Research Personnel; Resources; Rest; Selectins; Source; Stress; Sympathetic Nervous System; Tumor Necrosis Factor-alpha; United States National Institutes of Health; human TNF protein; leukocyte activation; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will examine the effects of a 12-week exercise intervention and a 12-week exercise plus diet intervention on inflammation and cell adhesion in 150 patients with hypertension (blood pressure 140/90 mm Hg but 120/80 mm Hg but 140/90 mm Hg) who are currently not on anti-hypertensive medication. Prior to and following the interventions, we will assess resting and stress-induced (mental stressor and treadmill exercise testing) changes in circulating levels of CRP, IL-6, TNF-alpha, sICAM-1, sE-selectin, expression of the ¿?2-integrin subunits CD11a and CD11b on leukocytes, leukocyte activation (pseudopod formation), and peripheral blood mononuclear cell (PBMC) chemotaxis.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 我们将研究150例高血压患者（血压140/90 mm HG，但120/80 mm HG，但140/90 mm Hg）的150例患者（血压140/90 mm HG）对注射术和细胞粘合剂的饮食干预和细胞粘合剂的影响，目前尚未服用抗静态毒性药物。 Prior to and following the interventions, we will assess resting and stress-induced (mental stressor and treadmill exercise testing) changes in circulating levels of CRP, IL-6, TNF-alpha, sICAM-1, sE-selectin, expression of the ¿ ?2-integrin subunits CD11a and CD11b on leukocytes, leukocyte activation (pseudopod formation), and peripheral blood单核细胞（PBMC）趋化性。