CLINICAL TRIAL: DIETARY MACRONUTRIENT INTAKE AND EXERCISE ON GLUCOSE AND INSULIN

临床试验：膳食大量营养素摄入量以及葡萄糖和胰岛素的锻炼

• 批准号: 8166653
• 负责人: Agneta Lisbeth Sunehag
• 金额: $ 2.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166653
• 关键词: Address; Adolescent; Arts; Body fat; Calorimetry; Carbohydrates; Child; Childhood; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diet; Energy Metabolism; Etiology; Exercise; Fatty acid glycerol esters; Funding; Gluconeogenesis; Glucose; Grant; Impairment; Incidence; Institution; Insulin; Intake; Lead; Lipids; Lipolysis; Macronutrients Nutrition; Magnetic Resonance Imaging; Metabolic; Moderate Exercise; Non obese; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Physical activity; Prevalence; Research; Research Personnel; Resources; Risk; Source; Techniques; United States National Institutes of Health; glucose metabolism; glucose production; glycogenolysis; improved; insulin secretion; oxidation; prevent; programs; stable isotope; type 2 diabetes in children

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over the past 30 years the prevalence of overweight children (6-19 y) in the USA (BMI>95th percentile) has increased 3-fold to reach 13-14% in 1999. Concomitant with the increase in childhood overweight, the incidence of type 2 diabetes in children (0-19 y) has increased 4-fold. Although the etiology of obesity related impairment of glucose metabolism is multifactorial, dietary macronutrient intake and physical activity are potentially important factors. The aims of this proposal are to determine in healthy adolescents 1) the impact of obesity on energy expenditure and substrate oxidation, glucose production from gluconeogenesis and glycogenolysis, insulin secretion and sensitivity and lipolysis; 2) whether a 12 weeks moderate exercise program will improve glucose metabolism in obese adolescents, and if so, 3) whether the exercise effect is correlated with a decrease in intramyocellular fat content and/or increased lipid oxidation, and 4) whether dietary macronutrient composition of the diet impacts metabolic effects of exercise. To address these questions, 24 over weight (body fat >30%) and 24 non-obese (body fat <26%) adolescents will be studied on three occasions (just prior to the start of a 12 weeks exercise program, 6 weeks into the program and during the last week of exercise); in 24 subjects,12 obese and 12 non-obese, each of the three study occasions will be preceded by 7-d of a high carbohydrate diet, and in the other 24 of a 7-d high fat diet. State of the art stable isotope-GCMS techniques, MRI and 24 h room calorimetry will be used to obtain the data needed to address the aims stated above. The information provided by these studies will improve our understanding of the metabolic effects of obesity in adolescents and will lead to identifying factors, which may increase the risk of type 2 diabetes or prevent or delay the development of type 2 diabetes in adolescents.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在过去的30年中，美国超重儿童（6-19岁）的患病率（BMI> 95％）在1999年增加了3倍，达到13-14％。与童年超重的增加，儿童2型糖尿病的发生率（0-19 Y）增加了4倍。尽管与肥胖相关的葡萄糖代谢障碍的病因是多因素的，但饮食中的大量营养素摄入和体育活动是潜在的重要因素。该提案的目的是确定健康的青少年1）肥胖对能量消耗和底物氧化，糖异生的葡萄糖产生的影响，胰岛素分泌，胰岛素分泌以及敏感性以及脂解； 2）12周适度的运动计划是否会改善肥胖青少年的葡萄糖代谢，如果是的话，3）运动效应是否与细胞内脂肪含量的降低和/或脂质氧化增加相关，4）4）是否饮食中的饮食饮食饮食饮食饮食饮食的饮食中的大量成分会影响运动的代谢作用。 为了解决这些问题，将三次（就在计划开始了12周开始，在计划开始了6周之前，在运动的最后一周，将研究24次体重（体内脂肪> 30％）和24个非肥胖（体内脂肪<26％）的青少年；在24名受试者，12名肥胖和12个非肥胖症患者中，三个研究场合中的每一个都将在7-D的高碳水化合物饮食中，以及7-D高脂肪饮食的其他24个。最先进的同位素-GCMS技术，MRI和24小时的量热量法将用于获取以解决上述目的所需的数据。这些研究提供的信息将提高我们对青少年肥胖代谢作用的理解，并将导致识别因素，这可能会增加2型糖尿病的风险或预防或延迟青少年中2型糖尿病的发展。