COGNITIVE BENEFIT OF TREATING SLEEP APNEA IN PARKINSONS DISEASE DEMENTIA

治疗帕金森病痴呆症睡眠呼吸暂停的认知益处

• 批准号: 8166846
• 负责人: Sonia Ancoli-Israel
• 金额: $ 4.44万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166846
• 关键词: Area; Arousal; Attention; Cognition; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Continuous Positive Airway Pressure; Event; Funding; Grant; Institution; Measures; Moods; Parkinson' s Dementia; Patients; Polysomnography; Quality of life; Questionnaires; Reporting; Research; Research Personnel; Resources; Sleep; Sleep Apnea Syndromes; Source; Speed; Testing; United States National Institutes of Health; cognitive function; depressive symptoms; executive function; improved; respiratory; standardize measure; vigilance

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIM 1: Examine the effect of CPAP treatment on SDB and sleep in patients with SDB and PDD. Hypothesis 1: SDB and sleep will improve with CPAP treatment (i.e., the number of respiratory events and the number of desaturations will decrease and sleep will become less fragmented with fewer arousals as measured by polysomnography [PSG]) as compared to shamCPAP treatment. AIM 2: Examine the effect of CPAP treatment on daytime sleepiness, cognition, overall quality of life and mood in patients with SDB and PDD. Hypothesis 2: Improved sleep (defined by fewer arousals in nighttime PSG) and reduction of SDB (fewer respiratory events and decreased numbers of desaturations) following CPAP treatment will result in less daytime sleepiness (as measured by sleep latency on the multiple sleep latency test and subjective reports on the Epworth Sleepiness Scale), improvement in cognitive functioning (particularly in the areas of attention/vigilance, executive functioning and psychomotor speed), fewer depressive symptoms and improved quality of life as measured by standardized questionnaires.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 AIM 1：检查CPAP治疗对SDB的影响和SDB和PDD患者的睡眠。 假设1：通过CPAP处理，SDB和睡眠将改善（即，与ShamCPAP治疗相比，通过多个多摄影术[PSG]测量的呼吸事件的数量和去饱和度的数量将减少，睡眠的唤醒较少，而睡眠的分散较少。 AIM 2：检查CPAP治疗对SDB和PDD患者白天嗜睡，认知，整体生活质量和情绪的影响。 假设2：CPAP治疗后的SDB（由夜间PSG中较少唤醒定义）和SDB的减少（呼吸道事件和减少量减少）在CPAP治疗后会导致白天嗜睡（通过在多个睡眠潜伏期测试和对Epworth scoptor的主观性报告中，尤其是在认知功能的领域改善，在多个睡眠潜伏期中，在多个睡眠潜伏期测试中衡量）（通过睡眠延迟测试和在认知功能中的改善（在ePwortive scoption上）的工作（通过较少的睡眠测试来衡量）（在夜间PSG中的唤醒较少）（呼吸道事件和减少数量减少），尤其是在认知功能/方面，在认知功能中提高了，请逐渐增加速度），通过标准化问卷衡量的抑郁症状和改善的生活质量。