Action Monitoring in depression: ERP and fMRI correlates

抑郁症的行动监测：ERP 和 fMRI 的相关性

• 批准号: 7392191
• 负责人: AVRAM J HOLMES
• 金额: $ 0.72万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-07-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392191
• 关键词: Accounting; Address; Affective; Agitation; Amygdaloid structure; Anhedonia; Anterior; Awareness; Behavioral; Biological Neural Networks; Brain; Classification; Clinical; Clinical Treatment; Clinical assessments; Cognitive; Cognitive deficits; Conflict (Psychology); Coupled; Data; Depressed mood; Desire for food; Development; Diagnosis; Diagnostic; Dissociation; Event; Event-Related Potentials; Exhibits; Failure; Feedback; Feeling; Fellowship; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Guilt; Heterogeneity; Hospitalization; Impairment; Individual; Individual Differences; Intervention; Knowledge; Link; Literature; Localized; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mental Depression; Methodology; Methods; Modification; Monitor; Motor; Nature; Neurons; Neurosciences; Participant; Patient Self-Report; Patients; Pattern; Performance; Pharmacological Treatment; Phenotype; Plan B; Population; Prefrontal Cortex; Process; Rate; Relative (related person); Research; Research Training; Sleep disturbances; Staging; Stimulus; Structure; System; Techniques; Testing; Thinking; Translational Research; Treatment Efficacy; Variant; Work; behavior measurement; cingulate cortex; cognitive function; depressive symptoms; disorder control; dysphoria; executive function; hemodynamics; improved; neuroimaging; psychologic; relating to nervous system; response; treatment planning

DESCRIPTION (provided by applicant): Patients meeting clinical criteria for major depressive disorder (MOD) can present with varied clinical symptomatology including, but not limited to dysphoria, anhedonia, feelings of guilt/worthlessness, sleep disturbance, abnormal appetite, motor slowing, loss of energy, restlessness, and agitation. This heterogeneity within the current psychiatric nosological classification system interferes with the research and clinical treatment of MOD. Translational research, utilizing behavioral, electrophysiological, hemodynamic, and self-report methodology, offers the possibility to examine the correlation between the cortical regions hypothesized to be critical for distinct cognitive processes and variations in depressive symptomatology. As this research progresses the knowledge gained can be applied towards the implementation of targeted pharmacological treatments incorporating information pertaining to the involved neural regions of individual patients, and/or the tailoring of psychological therapies to address a specific pattern of dysfunction. The eventual result of this translational research would be the drastic improvement of treatment efficacy. Recently, advances in neuroimaging techniques have uncovered reliable structural and functional cortical abnormalities in patients with MOD. Specifically, evidence suggests that depression is associated with executive dysfunction, particularly in situations requiring adaptive behavioral adjustments in response to negative feedback or perceived failure. These deficits can be particularly debilitating, and are often associated with decreased functioning and increased hospitalization rates. When this literature is combined with findings implicating certain neural networks as critical subcomponents of adaptive behavioral responses clear patterns emerge. The project described herein proposes two studies to examine the neural underpinnings of this specific aspect of depressive symptomatology. In each study participants will perform a Stroop task coupled with a feedback manipulation. During the study sessions event-related potentials (ERP; study 1) and functional magnetic resonance imaging (fMRI; study 2) data will be collected. This research will assess the temporal and spatial nature of the cortical processes associated with the commission of errors and the receipt of task-relevant feedback in patients with MOD and healthy control participants. Isolating specific components of MOD and the associated underlying neural networks will encourage the development of individually tailored therapies and pharmacological interventions with the eventual goal of improving diagnoses and treatment.

描述（由申请人提供）：符合重度抑郁症（MOD）临床标准的患者可能会出现不同的临床症状，包括但不限于烦躁不安、快感缺失、内疚感/无价值感、睡眠障碍、食欲异常、运动减慢、丧失能力能量、焦躁和激动。当前精神病学分类系统中的这种异质性干扰了 MOD 的研究和临床治疗。转化研究利用行为、电生理学、血流动力学和自我报告方法，提供了检查假设对不同认知过程和抑郁症状变化至关重要的皮质区域之间的相关性的可能性。随着这项研究的进展，所获得的知识可以应用于实施有针对性的药物治疗，结合与个体患者所涉及的神经区域有关的信息，和/或定制心理治疗以解决特定的功能障碍模式。这项转化研究的最终结果将是治疗效果的大幅提高。最近，神经影像技术的进步已经发现了 MOD 患者可靠的结构和功能性皮质异常。具体来说，有证据表明抑郁症与执行功能障碍有关，特别是在需要适应性行为调整以应对负面反馈或感知失败的情况下。这些缺陷可能特别令人衰弱，并且通常与功能下降和住院率增加有关。当这些文献与暗示某些神经网络是适应性行为反应的关键组成部分的研究结果相结合时，就会出现清晰的模式。本文描述的项目提出了两项​​研究来检查抑郁症状学这一特定方面的神经基础。在每项研究中，参与者将执行斯特鲁普任务以及反馈操作。在研究期间，将收集事件相关电位（ERP；研究 1）和功能磁共振成像（fMRI；研究 2）数据。这项研究将评估 MOD 患者和健康对照参与者与犯错和接收任务相关反馈相关的皮质过程的时间和空间性质。分离 MOD 的特定成分和相关的基础神经网络将鼓励开发个体化治疗和药理学干预措施，最终目标是改善诊断和治疗。